IT1207508B - PROCEDURE FOR THE PREPARATION OF SILIBININ FREE FROM ISOSILIBINE AND MEDICATIONS CONTAINING DILIBININ. - Google Patents

PROCEDURE FOR THE PREPARATION OF SILIBININ FREE FROM ISOSILIBINE AND MEDICATIONS CONTAINING DILIBININ.

Info

Publication number
IT1207508B
IT1207508B IT8522933A IT2293385A IT1207508B IT 1207508 B IT1207508 B IT 1207508B IT 8522933 A IT8522933 A IT 8522933A IT 2293385 A IT2293385 A IT 2293385A IT 1207508 B IT1207508 B IT 1207508B
Authority
IT
Italy
Prior art keywords
isosilibine
dilibinin
silibinin
procedure
preparation
Prior art date
Application number
IT8522933A
Other languages
Italian (it)
Other versions
IT8522933A0 (en
Inventor
Rolf Madaus
Klaus Gorler
Hartwig Soicke
Original Assignee
Madaus & Co Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus & Co Dr filed Critical Madaus & Co Dr
Publication of IT8522933A0 publication Critical patent/IT8522933A0/en
Application granted granted Critical
Publication of IT1207508B publication Critical patent/IT1207508B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L59/00—Thermal insulation in general
    • F16L59/04—Arrangements using dry fillers, e.g. using slag wool which is added to the object to be insulated by pouring, spreading, spraying or the like

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
IT8522933A 1984-11-22 1985-11-21 PROCEDURE FOR THE PREPARATION OF SILIBININ FREE FROM ISOSILIBINE AND MEDICATIONS CONTAINING DILIBININ. IT1207508B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3442641 1984-11-22
DE19853537656 DE3537656A1 (en) 1984-11-22 1985-10-23 METHOD FOR PRODUCING ISOSILYBIN-FREE SILIBININE AND MEDICINAL PRODUCTS CONTAINING SILIBININE

Publications (2)

Publication Number Publication Date
IT8522933A0 IT8522933A0 (en) 1985-11-21
IT1207508B true IT1207508B (en) 1989-05-25

Family

ID=25826741

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8522933A IT1207508B (en) 1984-11-22 1985-11-21 PROCEDURE FOR THE PREPARATION OF SILIBININ FREE FROM ISOSILIBINE AND MEDICATIONS CONTAINING DILIBININ.

Country Status (26)

Country Link
US (1) US4871763A (en)
JP (1) JPH0678228B2 (en)
AR (1) AR241268A1 (en)
AT (1) AT391315B (en)
BE (1) BE903694A (en)
CA (1) CA1337125C (en)
CH (1) CH660008A5 (en)
CS (1) CS271321B2 (en)
DE (1) DE3537656A1 (en)
DK (3) DK166541B1 (en)
EG (1) EG17710A (en)
ES (2) ES8609312A1 (en)
FI (1) FI84065C (en)
FR (1) FR2573426B1 (en)
GB (1) GB2167746B (en)
HU (1) HU195504B (en)
IE (1) IE59209B1 (en)
IT (1) IT1207508B (en)
LU (1) LU86164A1 (en)
MX (1) MX172175B (en)
NL (1) NL192204C (en)
NO (1) NO160206C (en)
PL (1) PL146889B1 (en)
PT (1) PT81531B (en)
SE (1) SE457957B (en)
YU (1) YU43690B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3357383B2 (en) * 1991-08-14 2002-12-16 昌宏 黒田 Low molecular weight plant composition
DE4401902C2 (en) * 1994-01-24 2000-02-03 Madaus Ag Use of flavolignans as an adjuvant in tumor therapy
FR2719451B1 (en) * 1994-05-04 1996-07-26 Apcis Sa Use of silybinin in the force-feeding of palmipeds, with a view to obtaining a better quality foie gras.
DE19501266A1 (en) * 1995-01-18 1996-07-25 Madaus Ag Process for the preparation of flavano-lignan preparations with improved release and resorbability, preparations available thereafter and their use for the production of medicaments
US6379714B1 (en) 1995-04-14 2002-04-30 Pharmaprint, Inc. Pharmaceutical grade botanical drugs
DE69824223T2 (en) 1997-03-19 2004-09-30 Unilever N.V. Device for handling objects
GB2327607B8 (en) * 1997-07-31 2005-03-30 Litton Internat Company Ltd A process for producing a herbal extract composition
DE10053384A1 (en) * 2000-10-27 2002-05-08 Bionorica Arzneimittel Gmbh Pharmaceutical preparation made from milk thistle and terpenes
US6699900B2 (en) * 2001-04-07 2004-03-02 Jan E. Zielinski Hydrophilic and lipophilic silibinin pro-forms
DE10360954B3 (en) * 2003-12-23 2005-08-18 Esparma Gmbh Use of silibinin, its salts and / or its prodrugs together with α-lipoic acid for the treatment of chronic obstructive pulmonary diseases
BG65997B1 (en) * 2005-03-29 2010-09-30 "Софарма" Ад Method for silybinin preparation
PT2219642E (en) 2007-11-15 2011-10-18 Madaus Gmbh Silibinin component for the treatment of hepatitis
US8614341B2 (en) 2009-05-14 2013-12-24 Euromed S.A. Amorphous silibinin for the treatment of viral hepatitis
WO2011051742A1 (en) 2009-10-28 2011-05-05 Modutech S.A. Preparation comprising amino acids and plants and its activity in the alcohol detoxification
CN103408539B (en) * 2013-08-28 2016-04-06 天津泰阳制药有限公司 The production method of high-purity silymarin
EP3402788A1 (en) * 2016-01-15 2018-11-21 Universität Hamburg Flavonoide-type compounds bearing an o-rhamnosyl residue
JP2024510862A (en) 2020-09-29 2024-03-12 ムニセクハー メダサニ， Extracts and uses of bioactive compounds from milk thistle plants

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773932A (en) * 1968-06-01 1973-11-20 Madaus & Co Dr Method for recovering silymarin comprising polyhydroxyphenyl chromanones
DE1923082C3 (en) * 1969-05-06 1985-08-22 Dr. Madaus & Co, 5000 Koeln Process for the production of polyhydroxyphenylchromanones (Silymarin I-IV) and medicaments containing the polyhydroxyphenylchromanone (Silymarin I-IV = Silymarin I-IV group) mixture
DE1767666C3 (en) * 1968-06-01 1986-07-31 Dr. Madaus & Co, 5000 Koeln Pharmaceutical preparation for liver diseases
DE2416302B2 (en) * 1974-04-04 1978-02-02 Dr. Madaus & Co, 5000 Köln DIMERES AND TRIMERESILYBIN AND THEIR N-METHYLGLUCAMINE SALT AND METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
BE885558A (en) * 1980-10-07 1981-04-07 Madaus & Co Dr PROCESS FOR THE EXTRACTION OF SILYMARINE FROM THE PLANTS THUS OBTAINED SILYMARINE AND ITS USE IN THERAPEUTICS
DE3225688A1 (en) * 1982-07-09 1984-01-12 Suschnik Matthias Dr Process for the isolation of silymarin from Silybum marianum

Also Published As

Publication number Publication date
DK164866B (en) 1992-08-31
DK114592D0 (en) 1992-09-17
IT8522933A0 (en) 1985-11-21
CS837985A2 (en) 1990-02-12
YU43690B (en) 1989-10-31
CH660008A5 (en) 1987-03-13
ES8609312A1 (en) 1986-09-01
JPH05271071A (en) 1993-10-19
AT391315B (en) 1990-09-25
YU181285A (en) 1987-12-31
DK537685A (en) 1986-05-23
NL192204C (en) 1997-03-04
FI854536A (en) 1986-05-23
HU195504B (en) 1988-05-30
DK189491D0 (en) 1991-11-20
PT81531A (en) 1985-12-01
US4871763A (en) 1989-10-03
SE8505488D0 (en) 1985-11-20
NO160206B (en) 1988-12-12
SE8505488L (en) 1986-05-23
FR2573426B1 (en) 1988-06-10
DK189491A (en) 1991-11-20
NO160206C (en) 1989-03-22
GB2167746A (en) 1986-06-04
LU86164A1 (en) 1986-03-24
NO854657L (en) 1986-05-23
FR2573426A1 (en) 1986-05-23
IE59209B1 (en) 1994-01-26
PT81531B (en) 1987-11-11
ES554022A0 (en) 1987-04-01
MX172175B (en) 1993-12-07
BE903694A (en) 1986-05-22
FI854536A0 (en) 1985-11-18
HUT40115A (en) 1986-11-28
DK164866C (en) 1993-01-18
ES549119A0 (en) 1986-09-01
JPH0678228B2 (en) 1994-10-05
CA1337125C (en) 1995-09-26
AR241268A1 (en) 1992-04-30
DE3537656C2 (en) 1989-03-16
DE3537656A1 (en) 1986-05-22
GB8527809D0 (en) 1985-12-18
PL146889B1 (en) 1989-03-31
EG17710A (en) 1990-10-30
PL256373A1 (en) 1986-12-02
NL192204B (en) 1996-11-01
DK166541B1 (en) 1993-06-07
CS271321B2 (en) 1990-09-12
SE457957B (en) 1989-02-13
IE852927L (en) 1986-05-22
ATA337285A (en) 1990-03-15
FI84065B (en) 1991-06-28
ES8704482A1 (en) 1987-04-01
GB2167746B (en) 1989-01-11
DK114592A (en) 1992-09-17
DK172879B1 (en) 1999-09-06
NL8503136A (en) 1986-06-16
DK537685D0 (en) 1985-11-21
FI84065C (en) 1991-10-10

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971030