IT1196503B - Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto - Google Patents

Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto

Info

Publication number
IT1196503B
IT1196503B IT21146/86A IT2114686A IT1196503B IT 1196503 B IT1196503 B IT 1196503B IT 21146/86 A IT21146/86 A IT 21146/86A IT 2114686 A IT2114686 A IT 2114686A IT 1196503 B IT1196503 B IT 1196503B
Authority
IT
Italy
Prior art keywords
trifluoroacetyldaunorubicin
epi
keto
transformation
compound
Prior art date
Application number
IT21146/86A
Other languages
English (en)
Other versions
IT8621146A0 (it
Inventor
Gianpiero Turci
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Priority to IT21146/86A priority Critical patent/IT1196503B/it
Publication of IT8621146A0 publication Critical patent/IT8621146A0/it
Priority to JP62172053A priority patent/JPS6323894A/ja
Priority to EP87306272A priority patent/EP0253654A3/en
Application granted granted Critical
Publication of IT1196503B publication Critical patent/IT1196503B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT21146/86A 1986-07-16 1986-07-16 Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto IT1196503B (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT21146/86A IT1196503B (it) 1986-07-16 1986-07-16 Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto
JP62172053A JPS6323894A (ja) 1986-07-16 1987-07-09 ４′−ケト−ｎ−トリフルオロアセチルダウノルビシンを抗腫瘍性化合物を製造するための中間体である４′−エピ−ｎ−トリフルオロアセチルダウノルビシンまで変換する連続方法
EP87306272A EP0253654A3 (en) 1986-07-16 1987-07-15 Continuous process for transforming 4'-keto-n-trifluoroacetyldaunorubicin into 4'-epi-n-trifluoroacetyl-daunorubicin, an intermediate for preparing an anti-tumour compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21146/86A IT1196503B (it) 1986-07-16 1986-07-16 Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto

Publications (2)

Publication Number Publication Date
IT8621146A0 IT8621146A0 (it) 1986-07-16
IT1196503B true IT1196503B (it) 1988-11-16

Family

ID=11177421

Family Applications (1)

Application Number Title Priority Date Filing Date
IT21146/86A IT1196503B (it) 1986-07-16 1986-07-16 Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto

Country Status (3)

Country Link
EP (1) EP0253654A3 (it)
JP (1) JPS6323894A (it)
IT (1) IT1196503B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1275953B1 (it) * 1995-03-22 1997-10-24 Sicor Spa Procedimento per la preparazione di antibiotici della classe delle antracicline
SI0848009T1 (en) 1996-12-16 2000-12-31 Pharmachemie B.V. A process for preparing epirubicin or acid addition salts thereof from daunorubicin
US8802830B2 (en) 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4345068A (en) * 1979-11-22 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-epidaunorubicin, 3',4'-diepidaunorubicin, their doxorubicin analogs, and intermediates used in said process

Also Published As

Publication number Publication date
JPS6323894A (ja) 1988-02-01
EP0253654A3 (en) 1988-04-27
IT8621146A0 (it) 1986-07-16
EP0253654A2 (en) 1988-01-20

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