IT1185745B - N-Methyl 1-phenyl-2-amino-1,3-propane-diol derivs. - have anti:angina, local anaesthetic and anticonvulsant activity on smooth muscle - Google Patents
N-Methyl 1-phenyl-2-amino-1,3-propane-diol derivs. - have anti:angina, local anaesthetic and anticonvulsant activity on smooth muscleInfo
- Publication number
- IT1185745B IT1185745B IT2696978A IT2696978A IT1185745B IT 1185745 B IT1185745 B IT 1185745B IT 2696978 A IT2696978 A IT 2696978A IT 2696978 A IT2696978 A IT 2696978A IT 1185745 B IT1185745 B IT 1185745B
- Authority
- IT
- Italy
- Prior art keywords
- methyl
- derivs
- angina
- phenyl
- amino
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 4
- 206010002383 Angina Pectoris Diseases 0.000 title abstract 2
- 230000003444 anaesthetic effect Effects 0.000 title abstract 2
- 230000001773 anti-convulsant effect Effects 0.000 title abstract 2
- 239000001961 anticonvulsive agent Substances 0.000 title abstract 2
- 229960003965 antiepileptics Drugs 0.000 title abstract 2
- 210000002460 smooth muscle Anatomy 0.000 title abstract 2
- SOKBWEQHPUIPMD-UHFFFAOYSA-N 2-(methylamino)-1-phenylpropane-1,3-diol Chemical compound CNC(CO)C(O)C1=CC=CC=C1 SOKBWEQHPUIPMD-UHFFFAOYSA-N 0.000 title 1
- 125000000579 2,2-diphenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 abstract 2
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 229960004194 lidocaine Drugs 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- IMWJXPIKVXIELL-UHFFFAOYSA-N n-[2-(1-methylcyclohexa-2,4-dien-1-yl)ethyl]-3,3-diphenylpropan-1-amine Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CCNCCC1(C)CC=CC=C1 IMWJXPIKVXIELL-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
N-Alkyl-1-phenyl-2-amino-1, 3-propanediol derivs of formula (I) as the isomers or their mixts. and their salts are new (where R1 is H, 1-8C alkyl or phenoxymethyl and R2 is H, 1-8C alkyl, or 2,2-diphenylethyl with the conditions that when R1 is phenoxymethyl then R2 is methyl and when R2 is 2, 2-diphenylethyl then R1 is H). (I) are anti-angina active cpds. some of which have superior activity to prenilamine (3, 3-diphenyl-propyl -1-methyl-phenylethylamine). Some of the cpds. have local anaesthetic activity and anticonvulsant activity on smooth muscle, with some having superior activity to lidocaine. The cpds. have low toxicity e.g. oral LD50 in mice in range 700-2000 mg/kg, i.v. LD50.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2696978A IT1185745B (en) | 1978-08-24 | 1978-08-24 | N-Methyl 1-phenyl-2-amino-1,3-propane-diol derivs. - have anti:angina, local anaesthetic and anticonvulsant activity on smooth muscle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2696978A IT1185745B (en) | 1978-08-24 | 1978-08-24 | N-Methyl 1-phenyl-2-amino-1,3-propane-diol derivs. - have anti:angina, local anaesthetic and anticonvulsant activity on smooth muscle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7826969A0 IT7826969A0 (en) | 1978-08-24 |
| IT1185745B true IT1185745B (en) | 1987-11-12 |
Family
ID=11220653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2696978A IT1185745B (en) | 1978-08-24 | 1978-08-24 | N-Methyl 1-phenyl-2-amino-1,3-propane-diol derivs. - have anti:angina, local anaesthetic and anticonvulsant activity on smooth muscle |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1185745B (en) |
-
1978
- 1978-08-24 IT IT2696978A patent/IT1185745B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| IT7826969A0 (en) | 1978-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950830 |