IT1182706B - METHOD FOR THE DETERMINATION OF CATHEPSIN AND IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES AND COMPOUNDS USED IN SUCH DETERMINATION - Google Patents

METHOD FOR THE DETERMINATION OF CATHEPSIN AND IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES AND COMPOUNDS USED IN SUCH DETERMINATION

Info

Publication number
IT1182706B
IT1182706B IT48107/84A IT4810784A IT1182706B IT 1182706 B IT1182706 B IT 1182706B IT 48107/84 A IT48107/84 A IT 48107/84A IT 4810784 A IT4810784 A IT 4810784A IT 1182706 B IT1182706 B IT 1182706B
Authority
IT
Italy
Prior art keywords
determination
cathepsin
compounds used
proteolytic enzymes
proteolytic
Prior art date
Application number
IT48107/84A
Other languages
Italian (it)
Other versions
IT8448107A0 (en
Inventor
David N Haney
Original Assignee
Kimberly Clark Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Co filed Critical Kimberly Clark Co
Publication of IT8448107A0 publication Critical patent/IT8448107A0/en
Application granted granted Critical
Publication of IT1182706B publication Critical patent/IT1182706B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/06—Quantitative determination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/20—Coumarin derivatives
    • C12Q2337/22—7-Amino-4-methylcoumarin, i.e. AMC, MCA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/20—Coumarin derivatives
    • C12Q2337/24—7-Amino-4-trifluoromethylcoumarin, i.e. AFC
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466—Cysteine endopeptidases (3.4.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
IT48107/84A 1983-04-28 1984-04-30 METHOD FOR THE DETERMINATION OF CATHEPSIN AND IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES AND COMPOUNDS USED IN SUCH DETERMINATION IT1182706B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48965183A 1983-04-28 1983-04-28
US59833184A 1984-04-12 1984-04-12

Publications (2)

Publication Number Publication Date
IT8448107A0 IT8448107A0 (en) 1984-04-30
IT1182706B true IT1182706B (en) 1987-10-05

Family

ID=27049779

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48107/84A IT1182706B (en) 1983-04-28 1984-04-30 METHOD FOR THE DETERMINATION OF CATHEPSIN AND IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES AND COMPOUNDS USED IN SUCH DETERMINATION

Country Status (12)

Country Link
KR (1) KR850002289A (en)
AU (1) AU2743284A (en)
BR (1) BR8401996A (en)
DE (1) DE3415636A1 (en)
DK (1) DK201084A (en)
ES (1) ES8604691A1 (en)
FI (1) FI841686A (en)
FR (1) FR2545503A1 (en)
GB (1) GB2140423A (en)
IT (1) IT1182706B (en)
NL (1) NL8401375A (en)
SE (1) SE8402305L (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803162A (en) * 1984-05-15 1989-02-07 Fluorodiagnostic Limited Partners Composition, article and process for detecting a microorganism
US4908309A (en) * 1986-03-11 1990-03-13 Prototek, Inc. Method of detecting cysteine proteases
EP0255341B1 (en) * 1986-07-29 1993-02-03 Sunstar Kabushiki Kaisha Reagent for testing periodontal diseases
US20060223826A1 (en) * 2002-11-19 2006-10-05 Takeda Pharmaceutical Company Limited Intellectual Property Department Indole derivatives as somatostatin agonists or antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE407571B (en) * 1975-07-11 1979-04-02 Kabi Ab NEW CHROMOGENA ENZYME SUBSTRATE FOR SERINE PROTEASES
SE407405B (en) * 1975-07-11 1979-03-26 Kabi Ab NEW CHROMOGENATE THROMBIN SUBSTRATE
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity
CH634662A5 (en) * 1976-05-28 1983-02-15 Pentapharm Ag USE OF TRIPEPTIDE DERIVATIVES FOR THE QUANTITATIVE DETERMINATION OF PLASMINOGEN ACTIVATORS.
JPS5524147A (en) * 1978-08-10 1980-02-21 Ajinomoto Co Inc Peptide derivative
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
WO1982000641A1 (en) * 1980-08-25 1982-03-04 Ab Kabivitrum Peptide substrates for determination of protease activity
JPS5753446A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide derivative
JPS5863399A (en) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd Novel substrate for measuring plasmin

Also Published As

Publication number Publication date
GB8410841D0 (en) 1984-06-06
SE8402305L (en) 1984-10-29
SE8402305D0 (en) 1984-04-27
DK201084A (en) 1984-10-29
DE3415636A1 (en) 1984-10-31
FR2545503A1 (en) 1984-11-09
ES531962A0 (en) 1986-02-01
NL8401375A (en) 1984-11-16
FI841686A (en) 1984-10-29
KR850002289A (en) 1985-05-10
FI841686A0 (en) 1984-04-27
IT8448107A0 (en) 1984-04-30
DK201084D0 (en) 1984-04-18
GB2140423A (en) 1984-11-28
AU2743284A (en) 1984-11-01
BR8401996A (en) 1984-12-04
ES8604691A1 (en) 1986-02-01

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