IT1164696B - N-cyano isothiourea cpds. - useful as intermediates for histamine H2 receptor antagonists - Google Patents

N-cyano isothiourea cpds. - useful as intermediates for histamine H2 receptor antagonists

Info

Publication number
IT1164696B
IT1164696B IT4968479A IT4968479A IT1164696B IT 1164696 B IT1164696 B IT 1164696B IT 4968479 A IT4968479 A IT 4968479A IT 4968479 A IT4968479 A IT 4968479A IT 1164696 B IT1164696 B IT 1164696B
Authority
IT
Italy
Prior art keywords
cpds
histamine
cyano
useful
receptor antagonists
Prior art date
Application number
IT4968479A
Other languages
Italian (it)
Other versions
IT7949684A0 (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/936,668 external-priority patent/US4157347A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IT7949684A0 publication Critical patent/IT7949684A0/en
Application granted granted Critical
Publication of IT1164696B publication Critical patent/IT1164696B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

N-Cyano isothioureas of formula R5S-C(=N-CN)-NH-R1 (I) and their acid addition salts are new. In (I) R1 is 3-9C straight or branched alkynyl; and R5 is (lower)alkyl, phenylalkyl or phenyl contg. NO2, Cl and/or BR substit(s). (I) can be reacted with 2- (4-methyl-5-imidazolyl)methylthio ethylamine to form cpds. of formula (II) which are histamine H2 receptor antagonists which are effective inhibitors of gastric secretion in animals, including man, and which are useful in the treatment of peptic ulcer disease.
IT4968479A 1978-08-24 1979-07-06 N-cyano isothiourea cpds. - useful as intermediates for histamine H2 receptor antagonists IT1164696B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/936,668 US4157347A (en) 1977-06-03 1978-08-24 N-cyano isothioureas

Publications (2)

Publication Number Publication Date
IT7949684A0 IT7949684A0 (en) 1979-07-06
IT1164696B true IT1164696B (en) 1987-04-15

Family

ID=25468934

Family Applications (1)

Application Number Title Priority Date Filing Date
IT4968479A IT1164696B (en) 1978-08-24 1979-07-06 N-cyano isothiourea cpds. - useful as intermediates for histamine H2 receptor antagonists

Country Status (5)

Country Link
AT (1) AT362388B (en)
BE (1) BE874707R (en)
IT (1) IT1164696B (en)
LU (1) LU81026A1 (en)
PH (1) PH14341A (en)

Also Published As

Publication number Publication date
LU81026A1 (en) 1979-10-30
BE874707R (en) 1979-09-10
ATA486879A (en) 1980-10-15
IT7949684A0 (en) 1979-07-06
AT362388B (en) 1981-05-11
PH14341A (en) 1981-05-29

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