IT1140776B - 24,24-difluoro-1, alfa,25-diidrossicolecalciferolo - Google Patents

24,24-difluoro-1, alfa,25-diidrossicolecalciferolo

Info

Publication number
IT1140776B
IT1140776B IT20508/80A IT2050880A IT1140776B IT 1140776 B IT1140776 B IT 1140776B IT 20508/80 A IT20508/80 A IT 20508/80A IT 2050880 A IT2050880 A IT 2050880A IT 1140776 B IT1140776 B IT 1140776B
Authority
IT
Italy
Prior art keywords
dihydroxycolciferol
difluoro
alpha
Prior art date
Application number
IT20508/80A
Other languages
English (en)
Other versions
IT8020508A0 (it
Inventor
Hector F Delluca
Heinrich K Schnoes
Nobuo Ikekawa
Yoko Tanaka
Yoshiro Kobayashi
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of IT8020508A0 publication Critical patent/IT8020508A0/it
Application granted granted Critical
Publication of IT1140776B publication Critical patent/IT1140776B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/48—Halogenated derivatives
    • C07C35/52—Alcohols with a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT20508/80A 1979-03-28 1980-03-11 24,24-difluoro-1, alfa,25-diidrossicolecalciferolo IT1140776B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/024,848 US4201881A (en) 1979-03-28 1979-03-28 24,24-Difluoro-1α,25-dihydroxycholecalciferol

Publications (2)

Publication Number Publication Date
IT8020508A0 IT8020508A0 (it) 1980-03-11
IT1140776B true IT1140776B (it) 1986-10-10

Family

ID=21822707

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20508/80A IT1140776B (it) 1979-03-28 1980-03-11 24,24-difluoro-1, alfa,25-diidrossicolecalciferolo

Country Status (15)

Country Link
US (1) US4201881A (it)
JP (2) JPS6342618B2 (it)
AU (1) AU530015B2 (it)
BE (1) BE882143A (it)
CH (1) CH650240A5 (it)
DK (1) DK147300C (it)
FR (1) FR2452481A1 (it)
GB (2) GB2067567B (it)
IE (1) IE49753B1 (it)
IL (1) IL58526A (it)
IT (1) IT1140776B (it)
NL (1) NL7920190A (it)
NZ (1) NZ191900A (it)
SE (1) SE8008339L (it)
WO (1) WO1980002028A1 (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same
NZ201702A (en) * 1981-08-28 1985-08-16 Hoffmann La Roche 1 alpha,25-dihydroxy-(24r or 24s)-fluorocholecal-ciferol and intermediates;pharmaceutical compositions
DE3317562A1 (de) * 1982-05-17 1983-11-17 F. Hoffmann-La Roche & Co AG, 4002 Basel Verwendung eines cholecalciferolderivates
US4456689A (en) * 1982-05-17 1984-06-26 Becton Dickinson And Company Competitive protein binding assay using an organosilane-silica gel separation medium
US4428946A (en) * 1982-07-26 1984-01-31 Wisconsin Alumni Research Foundation Method of preventing milk fever in dairy cattle
JPS6253960A (ja) * 1985-05-30 1987-03-09 Taisho Pharmaceut Co Ltd ビタミンｄ↓３の誘導体
EP0245524B1 (en) * 1985-11-21 1991-04-17 Taisho Pharmaceutical Co. Ltd Vitamin d 3 derivative
US4853378A (en) * 1986-10-20 1989-08-01 Sumitomo Chemical Company, Limited Fluorine derivatives of vitamin D3 and process for producing the same
WO1990009179A1 (en) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Treatment of tibial dyschondroplasia
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5063234A (en) * 1990-05-25 1991-11-05 Eli Lilly And Company Method of inhibiting demineralization of bone
US7718637B2 (en) * 2007-12-28 2010-05-18 Wisconsin Alumni Research Foundation (20S)-23,23-difluoro-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs
JP5504898B2 (ja) 2010-01-08 2014-05-28 セントラル硝子株式会社 ジフルオロシクロプロパン化合物の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3741996A (en) * 1971-12-02 1973-06-26 Wisconsin Alumni Res Found 1{60 -hydroxycholecalciferol
US3969700A (en) * 1974-04-10 1976-07-13 International Business Machines Corporation Regional context maximum likelihood error correction for OCR, keyboard, and the like
FR2267590B1 (it) * 1974-04-10 1977-05-20 Ibm
JPS5729745B2 (it) * 1974-09-25 1982-06-24
US3993675A (en) * 1975-02-24 1976-11-23 Hoffmann-La Roche Inc. Process for the preparation of 1α,25-dihydroxycholecalciferol
US4069321A (en) * 1975-10-14 1978-01-17 Merck & Co., Inc. Blocked cholecalciferol and dihydrotachysterol 3 derivatives
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same

Also Published As

Publication number Publication date
JPS6342618B2 (it) 1988-08-24
AU530015B2 (en) 1983-06-30
FR2452481A1 (fr) 1980-10-24
JPS56500296A (it) 1981-03-12
CH650240A5 (de) 1985-07-15
IL58526A0 (en) 1980-01-31
DK147300B (da) 1984-06-12
SE8008339L (sv) 1980-11-27
GB2045765B (en) 1983-06-15
GB2045765A (en) 1980-11-05
JPH0146504B2 (it) 1989-10-09
FR2452481B1 (it) 1984-10-19
WO1980002028A1 (en) 1980-10-02
JPS63179855A (ja) 1988-07-23
GB2067567B (en) 1983-03-02
BE882143A (fr) 1980-07-01
IE49753B1 (en) 1985-12-11
NZ191900A (en) 1984-11-09
DK505080A (da) 1980-11-27
IT8020508A0 (it) 1980-03-11
IE800619L (en) 1980-09-28
AU5581080A (en) 1980-10-02
DK147300C (da) 1984-12-24
IL58526A (en) 1983-05-15
NL7920190A (nl) 1981-01-30
GB2067567A (en) 1981-07-30
US4201881A (en) 1980-05-06

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