IT1099191B - 1-Thiomethyl-1-de:carboxy-lasalocid derivs. - used as antihypertensive and cardiovascular agents - Google Patents
1-Thiomethyl-1-de:carboxy-lasalocid derivs. - used as antihypertensive and cardiovascular agentsInfo
- Publication number
- IT1099191B IT1099191B IT2810978A IT2810978A IT1099191B IT 1099191 B IT1099191 B IT 1099191B IT 2810978 A IT2810978 A IT 2810978A IT 2810978 A IT2810978 A IT 2810978A IT 1099191 B IT1099191 B IT 1099191B
- Authority
- IT
- Italy
- Prior art keywords
- lower alkyl
- derivs
- carboxy
- antihypertensive
- lasalocid
- Prior art date
Links
- 239000002220 antihypertensive agent Substances 0.000 title abstract 2
- 229940030600 antihypertensive agent Drugs 0.000 title abstract 2
- 230000003276 anti-hypertensive effect Effects 0.000 title 1
- 239000002327 cardiovascular agent Substances 0.000 title 1
- 229940125692 cardiovascular agent Drugs 0.000 title 1
- 229960000320 lasalocid Drugs 0.000 title 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 206010022562 Intermittent claudication Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000003727 cerebral blood flow Effects 0.000 abstract 1
- 208000024980 claudication Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- BBMULGJBVDDDNI-OWKLGTHSSA-N lasalocid Chemical compound C([C@@H]1[C@@]2(CC)O[C@@H]([C@H](C2)C)[C@@H](CC)C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCC=2C(=C(O)C(C)=CC=2)C(O)=O)C[C@](O)(CC)[C@H](C)O1 BBMULGJBVDDDNI-OWKLGTHSSA-N 0.000 abstract 1
- BBMULGJBVDDDNI-UHFFFAOYSA-N lasalocid A Natural products C=1C=C(C)C(O)=C(C(O)=O)C=1CCC(C)C(O)C(C)C(=O)C(CC)C(C(C1)C)OC1(CC)C1CCC(O)(CC)C(C)O1 BBMULGJBVDDDNI-UHFFFAOYSA-N 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
(A) Lasalocide derivs. of formula (I) are new (R1 is aryl (opt. substd.), heteroaryl, aralkyl, cycloalkyl, lower alkyl, lower alkenyl, alkoxycarbonyl-lower alkyl, aminoalkyl, lower alkylaminoalkyl, di-(lower alkyl)-aminoalkyl, hydroxyalkyl, alkoxyalkyl, thioalkoxyalkyl, carboxy-lower alkyl or H). (B) Intermediates of formula (II) (see "Preparation) are new. (I) are antihypertensive agents, esp. for oral use. They can also be used for treating other cardiovascular syndromes, e.g. angina pectoris, claudication and reduced cerebral blood flow.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83635077A | 1977-09-26 | 1977-09-26 | |
| US05/921,645 US4193928A (en) | 1977-09-26 | 1978-07-03 | Lasalocid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT7828109A0 IT7828109A0 (en) | 1978-09-26 |
| IT1099191B true IT1099191B (en) | 1985-09-18 |
Family
ID=27125862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2810978A IT1099191B (en) | 1977-09-26 | 1978-09-26 | 1-Thiomethyl-1-de:carboxy-lasalocid derivs. - used as antihypertensive and cardiovascular agents |
Country Status (12)
| Country | Link |
|---|---|
| AR (1) | AR222312A1 (en) |
| DE (1) | DE2861018D1 (en) |
| DK (1) | DK425278A (en) |
| ES (1) | ES473636A1 (en) |
| FI (1) | FI782934A (en) |
| GR (1) | GR72000B (en) |
| IL (1) | IL55619A0 (en) |
| IT (1) | IT1099191B (en) |
| MC (1) | MC1209A1 (en) |
| NO (1) | NO783243L (en) |
| NZ (1) | NZ188484A (en) |
| PT (1) | PT68588A (en) |
-
1978
- 1978-09-22 IL IL7855619A patent/IL55619A0/en unknown
- 1978-09-22 NZ NZ18848478A patent/NZ188484A/en unknown
- 1978-09-22 MC MC781327A patent/MC1209A1/en unknown
- 1978-09-25 AR AR27383178A patent/AR222312A1/en active
- 1978-09-25 NO NO783243A patent/NO783243L/en unknown
- 1978-09-25 GR GR57296A patent/GR72000B/el unknown
- 1978-09-25 ES ES473636A patent/ES473636A1/en not_active Expired
- 1978-09-25 DK DK425278A patent/DK425278A/en unknown
- 1978-09-25 PT PT6858878A patent/PT68588A/en unknown
- 1978-09-26 DE DE7878100991T patent/DE2861018D1/en not_active Expired
- 1978-09-26 IT IT2810978A patent/IT1099191B/en active
- 1978-09-26 FI FI782934A patent/FI782934A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR222312A1 (en) | 1981-05-15 |
| NO783243L (en) | 1979-03-27 |
| GR72000B (en) | 1983-08-26 |
| IL55619A0 (en) | 1978-12-17 |
| DK425278A (en) | 1979-03-27 |
| FI782934A (en) | 1979-03-27 |
| NZ188484A (en) | 1981-05-01 |
| DE2861018D1 (en) | 1981-11-26 |
| MC1209A1 (en) | 1979-05-18 |
| PT68588A (en) | 1978-10-01 |
| ES473636A1 (en) | 1979-04-16 |
| IT7828109A0 (en) | 1978-09-26 |
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