IT1046052B - 1-Aralkyl-4-aminomethyl-piperidin-4-ols prepn - by redn of corresp. 4-nitromethyl-piperidine-4-ols - Google Patents

1-Aralkyl-4-aminomethyl-piperidin-4-ols prepn - by redn of corresp. 4-nitromethyl-piperidine-4-ols

Info

Publication number
IT1046052B
IT1046052B IT3006973A IT3006973A IT1046052B IT 1046052 B IT1046052 B IT 1046052B IT 3006973 A IT3006973 A IT 3006973A IT 3006973 A IT3006973 A IT 3006973A IT 1046052 B IT1046052 B IT 1046052B
Authority
IT
Italy
Prior art keywords
ols
redn
corresp
aralkyl
nitromethyl
Prior art date
Application number
IT3006973A
Other languages
Italian (it)
Original Assignee
Sigurta Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigurta Farmaceutici Spa filed Critical Sigurta Farmaceutici Spa
Priority to IT3006973A priority Critical patent/IT1046052B/en
Priority to BE147274A priority patent/BE818471A/en
Application granted granted Critical
Publication of IT1046052B publication Critical patent/IT1046052B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4

Abstract

The title cpds. of formula (I): (where R is benzyl or phenethyl) are obtd. by redn. of cpds. of formula (II), which are themselves prepd. by reaction of the corresp. 1-aralkyl-4-piperidones (III) with nitromethane. Yields of >90% are obtd. (III) is converted to (II) by reaction with nitromethane is absolute C2H5OH at room temp. (II) is reduced with Zn in a mineral acide, e.g. HCl or H2SO4 in alcoholic medium, and (I) is obtd. in the form of an addn. cpd. of formula (I). ZnCl2.2HCl (II) are new cpds.
IT3006973A 1973-10-12 1973-10-12 1-Aralkyl-4-aminomethyl-piperidin-4-ols prepn - by redn of corresp. 4-nitromethyl-piperidine-4-ols IT1046052B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT3006973A IT1046052B (en) 1973-10-12 1973-10-12 1-Aralkyl-4-aminomethyl-piperidin-4-ols prepn - by redn of corresp. 4-nitromethyl-piperidine-4-ols
BE147274A BE818471A (en) 1973-10-12 1974-08-02 PROCESS FOR PREPARING 1-ARALKYL-4-AMINO-METHYLPIPERIDINE-4-OLS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT3006973A IT1046052B (en) 1973-10-12 1973-10-12 1-Aralkyl-4-aminomethyl-piperidin-4-ols prepn - by redn of corresp. 4-nitromethyl-piperidine-4-ols

Publications (1)

Publication Number Publication Date
IT1046052B true IT1046052B (en) 1980-06-30

Family

ID=11228970

Family Applications (1)

Application Number Title Priority Date Filing Date
IT3006973A IT1046052B (en) 1973-10-12 1973-10-12 1-Aralkyl-4-aminomethyl-piperidin-4-ols prepn - by redn of corresp. 4-nitromethyl-piperidine-4-ols

Country Status (2)

Country Link
BE (1) BE818471A (en)
IT (1) IT1046052B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH652713A5 (en) * 1981-01-28 1985-11-29 Sandoz Ag 4-AMINOMETHYL-POLYMETHYLPIPERIDINE.
TW548103B (en) * 1997-07-11 2003-08-21 Janssen Pharmaceutica Nv Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
CN102766147B (en) * 2012-08-03 2015-07-15 无锡药兴医药科技有限公司 Method for preparing fenspiride and halogen acid salt thereof

Also Published As

Publication number Publication date
BE818471A (en) 1974-12-02

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