IS2526B - Bensoxasepínafleiður og notkun þeirra sem AMPA viðtakahvatar - Google Patents

Bensoxasepínafleiður og notkun þeirra sem AMPA viðtakahvatar

Info

Publication number
IS2526B
IS2526B IS7036A IS7036A IS2526B IS 2526 B IS2526 B IS 2526B IS 7036 A IS7036 A IS 7036A IS 7036 A IS7036 A IS 7036A IS 2526 B IS2526 B IS 2526B
Authority
IS
Iceland
Prior art keywords
ampa receptor
benzoxazepine derivatives
catalyst
receptor catalyst
benzoxazepine
Prior art date
Application number
IS7036A
Other languages
English (en)
Other versions
IS7036A (is
Inventor
Mingqiang Zhang
Mohammad Shahid
Simon James Anthony Grove
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of IS7036A publication Critical patent/IS7036A/is
Publication of IS2526B publication Critical patent/IS2526B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IS7036A 2001-06-11 2003-11-13 Bensoxasepínafleiður og notkun þeirra sem AMPA viðtakahvatar IS2526B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202215 2001-06-11
PCT/EP2002/006185 WO2002100865A1 (en) 2001-06-11 2002-06-05 Benzoxazepine derivatives and their use as ampa receptor stimulators

Publications (2)

Publication Number Publication Date
IS7036A IS7036A (is) 2003-11-13
IS2526B true IS2526B (is) 2009-07-15

Family

ID=8180450

Family Applications (1)

Application Number Title Priority Date Filing Date
IS7036A IS2526B (is) 2001-06-11 2003-11-13 Bensoxasepínafleiður og notkun þeirra sem AMPA viðtakahvatar

Country Status (30)

Country Link
US (2) US7307073B2 (is)
EP (1) EP1399450B1 (is)
JP (1) JP4435561B2 (is)
KR (1) KR100863255B1 (is)
CN (1) CN1257908C (is)
AR (1) AR036092A1 (is)
AT (1) ATE389659T1 (is)
AU (1) AU2002314144B2 (is)
BR (1) BR0210222A (is)
CA (1) CA2450274C (is)
CO (1) CO5550447A2 (is)
CZ (1) CZ300052B6 (is)
DE (1) DE60225689T2 (is)
EC (1) ECSP034891A (is)
ES (1) ES2301651T3 (is)
HK (1) HK1061858A1 (is)
HR (1) HRP20031007A2 (is)
HU (1) HUP0400154A3 (is)
IL (2) IL158905A0 (is)
IS (1) IS2526B (is)
MX (1) MXPA03011563A (is)
NO (1) NO328705B1 (is)
NZ (1) NZ529670A (is)
PE (1) PE20030097A1 (is)
PL (1) PL366721A1 (is)
RU (1) RU2279434C2 (is)
SK (1) SK287150B6 (is)
TW (1) TWI232863B (is)
WO (1) WO2002100865A1 (is)
ZA (1) ZA200309382B (is)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03011562A (es) 2001-06-14 2004-03-18 Akzo Nobel Nv Derivados de (pirido/tieno)-(f)-oxazepin-5-ona como moduladores positivos del receptor ampa.
WO2010054336A2 (en) * 2008-11-10 2010-05-14 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
RS53164B (en) * 2009-09-28 2014-06-30 F. Hoffmann-La Roche Ag BENZOXAZEPINE PI3K INHIBITOR COMPOUNDS AND THEIR USE IN CANCER TREATMENT
FR2964969B1 (fr) 2010-09-16 2012-08-24 Servier Lab Nouveaux derives dihydrobenzoxathiazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2014277952A1 (en) 2013-06-13 2016-01-28 Veroscience Llc Compositions and methods for treating metabolic disorders
TWI794190B (zh) 2016-11-07 2023-03-01 加拿大商愛彼特生物製藥公司 含有取代的吡啶酮之三環化合物及其使用方法
TWI801517B (zh) 2018-03-12 2023-05-11 加拿大商愛彼特生物製藥公司 經取代的2-吡啶酮三環化合物、其類似物及其使用方法
EP3773584A4 (en) 2018-04-12 2022-01-05 Arbutus Biopharma Corporation METHOD FOR PRODUCING SUBSTITUTED PYRIDINONE-CONTAINING TRICYCLIC COMPOUNDS
US20230218632A1 (en) * 2020-03-20 2023-07-13 Amathus Therapeutics, Inc. Cyclic sulfonamide derivatives as trap1 modulators and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1238719A (is) 1968-11-01 1971-07-07
CA2138533C (en) 1992-07-24 2009-04-14 Gary S. Lynch Drugs that enhance synaptic responses mediated by ampa receptors
WO1996020941A1 (de) 1995-01-06 1996-07-11 F. Hoffmann-La Roche Ag Hydroxymethyl-imidazodiazepine und deren ester
US5650409A (en) * 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response
DE69831446T2 (de) 1997-06-09 2006-06-14 Pfizer Prod Inc Chinazolin-4-on AMPA Antagonisten
US5985871A (en) 1997-12-24 1999-11-16 Cortex Pharmaceuticals, Inc. Benzoxazine compounds for enhancing synaptic response
IL137720A0 (en) * 1998-02-18 2001-10-31 Neurosearch As Compounds and their use as positive ampa receptor modulators
US6124278A (en) 1998-04-03 2000-09-26 The Regents Of The University Of California Acylbenzoxazines for enhancing synaptic response

Also Published As

Publication number Publication date
WO2002100865A1 (en) 2002-12-19
US20080139529A1 (en) 2008-06-12
US20040171605A1 (en) 2004-09-02
NO20035486D0 (no) 2003-12-10
BR0210222A (pt) 2004-04-13
PL366721A1 (en) 2005-02-07
IL158905A0 (en) 2004-05-12
CO5550447A2 (es) 2005-08-31
TWI232863B (en) 2005-05-21
US7307073B2 (en) 2007-12-11
AR036092A1 (es) 2004-08-11
AU2002314144B2 (en) 2008-01-31
CN1514835A (zh) 2004-07-21
HUP0400154A2 (hu) 2004-07-28
EP1399450A1 (en) 2004-03-24
EP1399450B1 (en) 2008-03-19
CA2450274A1 (en) 2002-12-19
US7504390B2 (en) 2009-03-17
DE60225689D1 (de) 2008-04-30
KR100863255B1 (ko) 2008-10-15
IS7036A (is) 2003-11-13
CZ20033376A3 (en) 2004-04-14
CN1257908C (zh) 2006-05-31
ATE389659T1 (de) 2008-04-15
IL158905A (en) 2008-12-29
CZ300052B6 (cs) 2009-01-21
HUP0400154A3 (en) 2007-05-02
HK1061858A1 (en) 2004-10-08
NZ529670A (en) 2006-02-24
RU2004100310A (ru) 2005-06-10
SK15182003A3 (sk) 2004-05-04
HRP20031007A2 (en) 2005-10-31
ECSP034891A (es) 2004-01-28
MXPA03011563A (es) 2004-03-18
ES2301651T3 (es) 2008-07-01
NO328705B1 (no) 2010-05-03
JP4435561B2 (ja) 2010-03-17
CA2450274C (en) 2010-12-21
DE60225689T2 (de) 2008-07-17
JP2004533466A (ja) 2004-11-04
RU2279434C2 (ru) 2006-07-10
KR20040006030A (ko) 2004-01-16
SK287150B6 (sk) 2010-01-07
PE20030097A1 (es) 2003-02-08
ZA200309382B (en) 2005-03-02

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