IN2015KO00631A - - Google Patents
Info
- Publication number
- IN2015KO00631A IN2015KO00631A IN631KO2015A IN2015KO00631A IN 2015KO00631 A IN2015KO00631 A IN 2015KO00631A IN 631KO2015 A IN631KO2015 A IN 631KO2015A IN 2015KO00631 A IN2015KO00631 A IN 2015KO00631A
- Authority
- IN
- India
- Prior art keywords
- bilirubin
- diagnostic device
- gold nanoclusters
- luminescence intensity
- source
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/728—Bilirubin; including biliverdin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N21/643—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" non-biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6447—Fluorescence; Phosphorescence by visual observation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6432—Quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Optics & Photonics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention discloses a diagnostic device or kit for visual detection of bilirubin. Said diagnostic device or kit comprises chitosan stabilized gold nanoclusters based luminescence source, Cu2+ ions source for quenching luminescence intensity of said gold nanoclusters and recovery of quenched luminescence intensity in the presence of bilirubin. The said device enables non-invasive detection of hyperbilirubinemia by thumb impression visually or from blood serum.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/572,779 US11268967B2 (en) | 2015-06-04 | 2016-06-02 | Device for visual detection of bilirubin |
IN631KO2015 IN2015KO00631A (en) | 2015-06-04 | 2016-06-02 | |
EP16802704.3A EP3302449B1 (en) | 2015-06-04 | 2016-06-02 | A device for visual detection of bilirubin |
PCT/IN2016/000140 WO2016193996A1 (en) | 2015-06-04 | 2016-06-02 | A device for visual detection of bilirubin |
CN201680032322.1A CN107847463B (en) | 2015-06-04 | 2016-06-02 | Device for visually detecting bilirubin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN631KO2015 IN2015KO00631A (en) | 2015-06-04 | 2016-06-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2015KO00631A true IN2015KO00631A (en) | 2015-06-26 |
Family
ID=54394057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN631KO2015 IN2015KO00631A (en) | 2015-06-04 | 2016-06-02 |
Country Status (5)
Country | Link |
---|---|
US (1) | US11268967B2 (en) |
EP (1) | EP3302449B1 (en) |
CN (1) | CN107847463B (en) |
IN (1) | IN2015KO00631A (en) |
WO (1) | WO2016193996A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106267401B (en) * | 2016-08-31 | 2018-12-18 | 武汉仝干医疗科技股份有限公司 | Physics artificial liver nano-sized carbon chitin compound adsorptive reactor based on hollow fiber conduit |
AU2018326175A1 (en) | 2017-08-30 | 2020-03-05 | NeoLight LLC | System and methods for bilirubin analysis |
CN110133302A (en) * | 2019-05-09 | 2019-08-16 | 江苏师范大学 | Detect the paper chip and a kind of method of quickly detection content of bilirubin of bilirubin |
CN111157506B (en) * | 2020-01-17 | 2022-10-21 | 天津师范大学 | Method for detecting thioglycollic acid by using integrated fluorescent test paper |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3992158A (en) * | 1973-08-16 | 1976-11-16 | Eastman Kodak Company | Integral analytical element |
JP2856757B2 (en) * | 1989-03-13 | 1999-02-10 | ユニチカ株式会社 | Method for measuring total bilirubin and reagent for measurement |
US6882873B2 (en) | 1996-01-17 | 2005-04-19 | Respironics, Inc. | Method and system for determining bilirubin concentration |
WO2002018951A2 (en) * | 2000-08-29 | 2002-03-07 | The Rockefeller University | Methods employing fluorescence quenching by metal surfaces |
WO2006138698A2 (en) * | 2005-06-17 | 2006-12-28 | University Of Maryland Biotechnology Institute | Metal-enhanced fluorescence-based sensing methods |
US20060292700A1 (en) * | 2005-06-22 | 2006-12-28 | Naishu Wang | Diffused interrupted lateral flow immunoassay device and method |
US20120065614A1 (en) * | 2010-09-10 | 2012-03-15 | University Of North Texas | Polyionic transitional metal phosphorescent complex/polymer hybrid systems for bioimaging and sensing applications |
-
2016
- 2016-06-02 WO PCT/IN2016/000140 patent/WO2016193996A1/en active Application Filing
- 2016-06-02 EP EP16802704.3A patent/EP3302449B1/en active Active
- 2016-06-02 CN CN201680032322.1A patent/CN107847463B/en active Active
- 2016-06-02 IN IN631KO2015 patent/IN2015KO00631A/en unknown
- 2016-06-02 US US15/572,779 patent/US11268967B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3302449B1 (en) | 2020-04-01 |
CN107847463B (en) | 2021-06-22 |
CN107847463A (en) | 2018-03-27 |
EP3302449A4 (en) | 2019-01-09 |
US11268967B2 (en) | 2022-03-08 |
WO2016193996A1 (en) | 2016-12-08 |
US20180149663A1 (en) | 2018-05-31 |
EP3302449A1 (en) | 2018-04-11 |
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