IN2015DN03114A - - Google Patents

Info

Publication number
IN2015DN03114A
IN2015DN03114A IN3114DEN2015A IN2015DN03114A IN 2015DN03114 A IN2015DN03114 A IN 2015DN03114A IN 3114DEN2015 A IN3114DEN2015 A IN 3114DEN2015A IN 2015DN03114 A IN2015DN03114 A IN 2015DN03114A
Authority
IN
India
Prior art keywords
biphenylyl
fluoro
propionic acid
purification
synthesis
Prior art date
Application number
Inventor
Alan Michael Raymond
Barrie Rhodes
Original Assignee
Aesica Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aesica Pharmaceuticals Ltd filed Critical Aesica Pharmaceuticals Ltd
Publication of IN2015DN03114A publication Critical patent/IN2015DN03114A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

There is described (S)- (+)- 2- (2- fluoro- 4- biphenylyl) propionic acid, or a salt or ester thereof, having substantially limited amounts of specific impurities associated with the synthesis and purification of the (S)- (+) -2 -(2- fluoro- 4- biphenylyl) propionic acid.
IN3114DEN2015 2012-09-21 2013-09-20 IN2015DN03114A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1216893.6A GB201216893D0 (en) 2012-09-21 2012-09-21 Drug substance preparations, pharmaceutical compositions and dosage forms comprising s-(+)-flurbiprofen
PCT/GB2013/052464 WO2014045046A2 (en) 2012-09-21 2013-09-20 Drug substance preparations, pharmaceutical compositions and dosage forms comprising s-(+)-flurbiprofen

Publications (1)

Publication Number Publication Date
IN2015DN03114A true IN2015DN03114A (en) 2015-10-02

Family

ID=47190400

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3114DEN2015 IN2015DN03114A (en) 2012-09-21 2013-09-20

Country Status (8)

Country Link
US (1) US20150232407A1 (en)
EP (1) EP2897602A2 (en)
JP (2) JP2014062080A (en)
AU (2) AU2013320004A1 (en)
CA (1) CA2884173C (en)
GB (1) GB201216893D0 (en)
IN (1) IN2015DN03114A (en)
WO (1) WO2014045046A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015329319B2 (en) * 2014-10-07 2018-12-13 Taisho Pharmaceutical Co., Ltd. External preparation composition containing S-flurbiprofen
CN113651689B (en) * 2021-08-27 2022-06-10 上海博悦生物科技有限公司 Novel crystal form of S-flurbiprofen sodium and preparation method thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4209638A (en) 1977-03-08 1980-06-24 The Boots Company Limited Preparation of therapeutic agents
DE3824353A1 (en) 1988-07-19 1990-01-25 Paz Arzneimittelentwicklung METHOD FOR SEPARATING MIXED ENANTIOMER ARYLPROPIONIC ACIDS
US5190981A (en) * 1989-08-17 1993-03-02 Sepracor Inc. Formulation containing S(+) enantiomer of flurbiprofen or ketoprofen and method of use for oral administration for prevention and treatment of bone loss associated with periodontal disease
US5015764A (en) 1990-06-18 1991-05-14 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
DE69206306T2 (en) 1991-04-08 1996-06-13 Sumitomo Chemical Co Optically active secondary amine compound, process for producing an optically active secondary amine compound and process for producing optically active carboxylic acid by using this compound.
US5235100A (en) 1992-01-24 1993-08-10 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
RU2133733C1 (en) 1992-12-02 1999-07-27 Дзе бутс компани ПЛС. Method of synthesis of phenylpropionic acid
JP3782834B2 (en) 1994-10-26 2006-06-07 株式会社トクホン Analgesic anti-inflammatory patch
US5574183A (en) 1995-01-24 1996-11-12 Albemarle Corporation Preparation of optically active aliphatic carboxylic acids
GB9523833D0 (en) 1995-11-22 1996-01-24 Boots Co Plc Medical treatment
JP2006335639A (en) * 2003-01-23 2006-12-14 Nagase & Co Ltd Method for producing optically active flurbiprofen
CA2677125C (en) * 2007-02-01 2018-07-10 Myriad Genetics, Inc. Drug substance preparations, pharmaceutical compositions and dosage forms
GB0811851D0 (en) * 2008-06-30 2008-07-30 Aesica Pharmaceuticals Ltd Process

Also Published As

Publication number Publication date
WO2014045046A3 (en) 2014-06-26
JP2018035165A (en) 2018-03-08
AU2013320004A1 (en) 2015-04-30
WO2014045046A2 (en) 2014-03-27
JP2014062080A (en) 2014-04-10
CA2884173C (en) 2023-03-14
CA2884173A1 (en) 2014-03-27
AU2017279760A1 (en) 2018-02-01
GB201216893D0 (en) 2012-11-07
EP2897602A2 (en) 2015-07-29
US20150232407A1 (en) 2015-08-20

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