IN2015DN03114A - - Google Patents
Info
- Publication number
- IN2015DN03114A IN2015DN03114A IN3114DEN2015A IN2015DN03114A IN 2015DN03114 A IN2015DN03114 A IN 2015DN03114A IN 3114DEN2015 A IN3114DEN2015 A IN 3114DEN2015A IN 2015DN03114 A IN2015DN03114 A IN 2015DN03114A
- Authority
- IN
- India
- Prior art keywords
- biphenylyl
- fluoro
- propionic acid
- purification
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
There is described (S)- (+)- 2- (2- fluoro- 4- biphenylyl) propionic acid, or a salt or ester thereof, having substantially limited amounts of specific impurities associated with the synthesis and purification of the (S)- (+) -2 -(2- fluoro- 4- biphenylyl) propionic acid.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1216893.6A GB201216893D0 (en) | 2012-09-21 | 2012-09-21 | Drug substance preparations, pharmaceutical compositions and dosage forms comprising s-(+)-flurbiprofen |
PCT/GB2013/052464 WO2014045046A2 (en) | 2012-09-21 | 2013-09-20 | Drug substance preparations, pharmaceutical compositions and dosage forms comprising s-(+)-flurbiprofen |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2015DN03114A true IN2015DN03114A (en) | 2015-10-02 |
Family
ID=47190400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN3114DEN2015 IN2015DN03114A (en) | 2012-09-21 | 2013-09-20 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20150232407A1 (en) |
EP (1) | EP2897602A2 (en) |
JP (2) | JP2014062080A (en) |
AU (2) | AU2013320004A1 (en) |
CA (1) | CA2884173C (en) |
GB (1) | GB201216893D0 (en) |
IN (1) | IN2015DN03114A (en) |
WO (1) | WO2014045046A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2015329319B2 (en) * | 2014-10-07 | 2018-12-13 | Taisho Pharmaceutical Co., Ltd. | External preparation composition containing S-flurbiprofen |
CN113651689B (en) * | 2021-08-27 | 2022-06-10 | 上海博悦生物科技有限公司 | Novel crystal form of S-flurbiprofen sodium and preparation method thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4209638A (en) | 1977-03-08 | 1980-06-24 | The Boots Company Limited | Preparation of therapeutic agents |
DE3824353A1 (en) | 1988-07-19 | 1990-01-25 | Paz Arzneimittelentwicklung | METHOD FOR SEPARATING MIXED ENANTIOMER ARYLPROPIONIC ACIDS |
US5190981A (en) * | 1989-08-17 | 1993-03-02 | Sepracor Inc. | Formulation containing S(+) enantiomer of flurbiprofen or ketoprofen and method of use for oral administration for prevention and treatment of bone loss associated with periodontal disease |
US5015764A (en) | 1990-06-18 | 1991-05-14 | Ethyl Corporation | Preparation of optically active aliphatic carboxylic acids |
DE69206306T2 (en) | 1991-04-08 | 1996-06-13 | Sumitomo Chemical Co | Optically active secondary amine compound, process for producing an optically active secondary amine compound and process for producing optically active carboxylic acid by using this compound. |
US5235100A (en) | 1992-01-24 | 1993-08-10 | Ethyl Corporation | Preparation of optically active aliphatic carboxylic acids |
RU2133733C1 (en) | 1992-12-02 | 1999-07-27 | Дзе бутс компани ПЛС. | Method of synthesis of phenylpropionic acid |
JP3782834B2 (en) | 1994-10-26 | 2006-06-07 | 株式会社トクホン | Analgesic anti-inflammatory patch |
US5574183A (en) | 1995-01-24 | 1996-11-12 | Albemarle Corporation | Preparation of optically active aliphatic carboxylic acids |
GB9523833D0 (en) | 1995-11-22 | 1996-01-24 | Boots Co Plc | Medical treatment |
JP2006335639A (en) * | 2003-01-23 | 2006-12-14 | Nagase & Co Ltd | Method for producing optically active flurbiprofen |
CA2677125C (en) * | 2007-02-01 | 2018-07-10 | Myriad Genetics, Inc. | Drug substance preparations, pharmaceutical compositions and dosage forms |
GB0811851D0 (en) * | 2008-06-30 | 2008-07-30 | Aesica Pharmaceuticals Ltd | Process |
-
2012
- 2012-09-21 GB GBGB1216893.6A patent/GB201216893D0/en not_active Ceased
- 2012-10-05 JP JP2012222973A patent/JP2014062080A/en active Pending
-
2013
- 2013-09-20 WO PCT/GB2013/052464 patent/WO2014045046A2/en active Application Filing
- 2013-09-20 IN IN3114DEN2015 patent/IN2015DN03114A/en unknown
- 2013-09-20 AU AU2013320004A patent/AU2013320004A1/en not_active Abandoned
- 2013-09-20 EP EP13786529.1A patent/EP2897602A2/en not_active Ceased
- 2013-09-20 US US14/429,607 patent/US20150232407A1/en not_active Abandoned
- 2013-09-20 CA CA2884173A patent/CA2884173C/en active Active
-
2017
- 2017-09-11 JP JP2017173960A patent/JP2018035165A/en active Pending
- 2017-12-21 AU AU2017279760A patent/AU2017279760A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2014045046A3 (en) | 2014-06-26 |
JP2018035165A (en) | 2018-03-08 |
AU2013320004A1 (en) | 2015-04-30 |
WO2014045046A2 (en) | 2014-03-27 |
JP2014062080A (en) | 2014-04-10 |
CA2884173C (en) | 2023-03-14 |
CA2884173A1 (en) | 2014-03-27 |
AU2017279760A1 (en) | 2018-02-01 |
GB201216893D0 (en) | 2012-11-07 |
EP2897602A2 (en) | 2015-07-29 |
US20150232407A1 (en) | 2015-08-20 |
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