IN2015DN02513A - - Google Patents

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Publication number
IN2015DN02513A
IN2015DN02513A IN2513DEN2015A IN2015DN02513A IN 2015DN02513 A IN2015DN02513 A IN 2015DN02513A IN 2513DEN2015 A IN2513DEN2015 A IN 2513DEN2015A IN 2015DN02513 A IN2015DN02513 A IN 2015DN02513A
Authority
IN
India
Prior art keywords
preparation
compounds
antibiotics
ertapenem
intermediates
Prior art date
Application number
Inventor
Hannes Lengauer
Birgit Endl
Wolfgang Felzmann
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IN2015DN02513A publication Critical patent/IN2015DN02513A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

The present invention relates to the preparation of compounds, in particular to the preparation of compounds which may be used as intermediates for the preparation of antibiotics , preferably carbapenem antibiotics more preferably ertapenem , and salts thereof.
IN2513DEN2015 2012-10-12 2013-10-11 IN2015DN02513A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12188351 2012-10-12
PCT/EP2013/071252 WO2014057079A1 (en) 2012-10-12 2013-10-11 Preparation of ertapenem intermediates

Publications (1)

Publication Number Publication Date
IN2015DN02513A true IN2015DN02513A (en) 2015-09-11

Family

ID=47022553

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2513DEN2015 IN2015DN02513A (en) 2012-10-12 2013-10-11

Country Status (9)

Country Link
US (2) US9546171B2 (en)
EP (1) EP2906561A1 (en)
JP (1) JP2015533142A (en)
KR (1) KR20150065176A (en)
CN (1) CN104703986A (en)
AU (1) AU2013328585A1 (en)
CA (1) CA2887098A1 (en)
IN (1) IN2015DN02513A (en)
WO (1) WO2014057079A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104703986A (en) * 2012-10-12 2015-06-10 桑多斯股份公司 Preparation of Ertapenem intermediates
CN113880839A (en) * 2021-11-01 2022-01-04 石药集团中诺药业（石家庄）有限公司 Novel synthesis method of ertapenem sodium crude product

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202298D0 (en) 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
TW513430B (en) 1996-07-12 2002-12-11 Merck & Co Inc Process for synthesizing carbapenem antibiotics
KR100364339B1 (en) 1997-06-16 2002-12-18 머크 앤드 캄파니 인코포레이티드 Stabilized carbapenem intermediates and synthetic use
US5872250A (en) * 1997-07-30 1999-02-16 Merck & Co., Inc. Process for synthesizing carbapenem antibiotics
CA2457642C (en) 2001-09-26 2009-01-06 Merck & Co., Inc. Crystalline forms of ertapenem sodium
CN100457760C (en) * 2005-10-20 2009-02-04 上海交通大学 Preparation method of ertabeinan sodium salt
US8293894B2 (en) 2006-11-20 2012-10-23 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
KR101694506B1 (en) * 2009-04-30 2017-01-10 씨에스피씨 종콰이 팔마씨우티컬 테크놀로지 (스자좡) 컴퍼니 리미티드 Intermediates of ertapenem, compositions containing them and preparation methods thereof
US8729260B2 (en) * 2010-05-19 2014-05-20 Savior Lifetec Corporation Process for the preparation of carbapenem using cabapenem intermediates and recovery of cabapenem
US20110288289A1 (en) * 2010-05-19 2011-11-24 Savior Lifetec Corporation Preparation of Carbapenem Intermediate and Their Use
KR20120007331A (en) 2010-07-14 2012-01-20 주식회사 경보제약 An improved process for the preparation of carbapenem compounds
CN101935321A (en) * 2010-07-20 2011-01-05 深圳市海滨制药有限公司 Method for synthesizing 1 beta methyl carbapenem antibiotic
CN102731502B (en) 2011-04-13 2016-08-03 石药集团中奇制药技术（石家庄）有限公司 A kind of preparation method of carbapenem antibiotics
CN102351861A (en) * 2011-08-16 2012-02-15 湖南欧亚生物有限公司 Industrial preparation method of ertapenem
CN102432611B (en) * 2011-11-09 2013-11-20 上海希迈医药科技有限公司 Dual-protection ertapenem crystal and preparation method thereof
CN102731508A (en) * 2012-07-03 2012-10-17 浙江海翔川南药业有限公司 Crystal ertapenem intermediate as well as preparation method and application thereof
CN104703986A (en) * 2012-10-12 2015-06-10 桑多斯股份公司 Preparation of Ertapenem intermediates

Also Published As

Publication number Publication date
CA2887098A1 (en) 2014-04-17
AU2013328585A1 (en) 2015-04-09
CN104703986A (en) 2015-06-10
JP2015533142A (en) 2015-11-19
US9546171B2 (en) 2017-01-17
US20170166570A1 (en) 2017-06-15
US20150274732A1 (en) 2015-10-01
WO2014057079A1 (en) 2014-04-17
KR20150065176A (en) 2015-06-12
EP2906561A1 (en) 2015-08-19

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