IN2014MN02533A - - Google Patents

Info

Publication number
IN2014MN02533A
IN2014MN02533A IN2533MUN2014A IN2014MN02533A IN 2014MN02533 A IN2014MN02533 A IN 2014MN02533A IN 2533MUN2014 A IN2533MUN2014 A IN 2533MUN2014A IN 2014MN02533 A IN2014MN02533 A IN 2014MN02533A
Authority
IN
India
Prior art keywords
cyclopropyl
amino
method uses
hydroxyl hexanamide
nitrile
Prior art date
Application number
Inventor
Bangping Lin
Zhongmei Wang
Bin Guo
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN2012101939234A external-priority patent/CN102702016A/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IN2014MN02533A publication Critical patent/IN2014MN02533A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Abstract

The present invention discloses a method for preparing 3 amino N cyclopropyl 2 hydroxyl hexanamide. The invention relates to the technical field of the preparation of pharmaceutical intermediates. The method uses trans 2 hexenoic acid as the starting material through the steps of epoxidation ring opening by nitrile amidation etc. to obtain the final product 3 amino N cyclopropyl 2 hydroxyl hexanamide. The method uses easily obtainable materials requires mild reactive conditions and adopts stable processes. Therefore it is suitable for large scale industrial production.
IN2533MUN2014 2012-06-13 2013-06-12 IN2014MN02533A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2012101939234A CN102702016A (en) 2012-06-13 2012-06-13 Method for preparing 3-amino-N-cyclopropyl-2-hydroxyhexanamide
CN2012082591 2012-10-08
PCT/EP2013/062121 WO2013186248A1 (en) 2012-06-13 2013-06-12 A method for the preparation of 3-amino-n-cyclopropyl-2-hydroxyl-hexanamide

Publications (1)

Publication Number Publication Date
IN2014MN02533A true IN2014MN02533A (en) 2015-07-24

Family

ID=48579124

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2533MUN2014 IN2014MN02533A (en) 2012-06-13 2013-06-12

Country Status (5)

Country Link
EP (1) EP2861557A1 (en)
CN (1) CN104812733A (en)
BR (1) BR112014030870A2 (en)
IN (1) IN2014MN02533A (en)
WO (1) WO2013186248A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004298498B2 (en) 2003-12-11 2008-09-11 Schering Corporation Inhibitors of hepatitis C virus NS3/NS4a serine protease
US8399615B2 (en) * 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
EP1993993A1 (en) 2006-03-16 2008-11-26 Vertex Pharmaceuticals Incorporated Processes and intermediates for preparing steric compounds
WO2007138928A1 (en) * 2006-05-26 2007-12-06 Kaneka Corporation Process for production of optically active 3-amino-2 -hydroxypropionic cyclopropylamide derivatives and salts thereof
US20080108632A1 (en) * 2006-11-02 2008-05-08 Taigen Biotechnology Co., Ltd. Hcv protease inhibitors
CN101186587B (en) * 2006-11-16 2010-04-21 凯莱英医药化学（阜新）技术有限公司 Method for synthesizing derivative of beta-amino acid and intermediate product thereof
CN101691338B (en) * 2009-08-26 2013-08-14 凯莱英生命科学技术(天津)有限公司 Synthesis method of chiral epoxy compound and intermediate products and final product

Also Published As

Publication number Publication date
WO2013186248A1 (en) 2013-12-19
CN104812733A (en) 2015-07-29
EP2861557A1 (en) 2015-04-22
BR112014030870A2 (en) 2017-06-27

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