IN2014MN00933A - - Google Patents

Info

Publication number
IN2014MN00933A
IN2014MN00933A IN933MUN2014A IN2014MN00933A IN 2014MN00933 A IN2014MN00933 A IN 2014MN00933A IN 933MUN2014 A IN933MUN2014 A IN 933MUN2014A IN 2014MN00933 A IN2014MN00933 A IN 2014MN00933A
Authority
IN
India
Prior art keywords
insulin analogue
therapeutic agent
present
provides
preparation
Prior art date
Application number
Other languages
English (en)
Inventor
Piaoyang Sun
Lianshan Zhang
Jiajian Liu
Jijun Yuan
Chunqian Fang
Changan Sun
Hengli Yuan
Yali Wang
Original Assignee
Shanghai Hengrui Pharm Co Ltd
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Hengrui Pharm Co Ltd, Jiangsu Hengrui Medicine Co filed Critical Shanghai Hengrui Pharm Co Ltd
Publication of IN2014MN00933A publication Critical patent/IN2014MN00933A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Obesity (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
IN933MUN2014 2011-12-15 2012-11-22 IN2014MN00933A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201110422095 2011-12-15
PCT/CN2012/085054 WO2013086927A1 (zh) 2011-12-15 2012-11-22 人胰岛素类似物及其酰化衍生物

Publications (1)

Publication Number Publication Date
IN2014MN00933A true IN2014MN00933A (ko) 2015-05-01

Family

ID=48611849

Family Applications (1)

Application Number Title Priority Date Filing Date
IN933MUN2014 IN2014MN00933A (ko) 2011-12-15 2012-11-22

Country Status (15)

Country Link
US (1) US9458219B2 (ko)
EP (1) EP2784085A4 (ko)
JP (1) JP6153206B2 (ko)
KR (1) KR20140104994A (ko)
CN (2) CN103443122B (ko)
AU (1) AU2012350586B2 (ko)
BR (1) BR112014013483A2 (ko)
CA (1) CA2858253A1 (ko)
HK (1) HK1188795A1 (ko)
IN (1) IN2014MN00933A (ko)
MX (1) MX2014006698A (ko)
RU (1) RU2014127270A (ko)
TW (1) TW201323439A (ko)
WO (1) WO2013086927A1 (ko)
ZA (1) ZA201404417B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2908373T3 (es) 2015-08-25 2022-04-28 Novo Nordisk As Nuevos derivados de insulina y los usos médicos de los mismos
CN106496322A (zh) * 2015-09-07 2017-03-15 江苏恒瑞医药股份有限公司 人胰岛素或其类似物的酰化衍生物的制备方法
CN105491227A (zh) * 2015-11-20 2016-04-13 努比亚技术有限公司 一种消息排列方法和终端
EP3260548A1 (en) 2016-06-21 2017-12-27 Enzypep B.V. Enzymatic coupling of (oligo)peptides to the b-chain of an insulin receptor ligand
EP3495384A4 (en) * 2016-08-02 2020-02-26 Jiangsu Hengrui Medicine Co., Ltd. ACYLATED DERIVATIVE OF HUMAN INSULIN OR ANALOGUE OF IT
KR20200116130A (ko) * 2018-02-01 2020-10-08 지앙수 헨그루이 메디슨 컴퍼니 리미티드 인간 인슐린 유사체의 아실화된 유도체를 포함하는 약학 조성물 및 이의 제조 방법
MX2020007929A (es) * 2018-02-09 2020-10-01 Jiangsu Hengrui Medicine Co Gen percursor del codón optimizado y gen de péptido señal de analógo de la insulina humana.
WO2020120479A1 (en) 2018-12-11 2020-06-18 Sanofi Peptide binder
CN111909255A (zh) * 2019-05-10 2020-11-10 宁波鲲鹏生物科技有限公司 胰岛素衍生物及其制备方法
JP6995284B2 (ja) 2019-12-11 2022-01-14 ノヴォ ノルディスク アー/エス 新規インスリン類似体およびそれらの使用
CN114901682B (zh) 2019-12-30 2024-04-16 甘李药业股份有限公司 胰岛素衍生物
CN113773398B (zh) * 2020-06-10 2023-05-23 宁波鲲鹏生物科技有限公司 一种德谷胰岛素衍生物及其应用
JP2024521757A (ja) * 2021-05-24 2024-06-04 サンシャイン・レイク・ファーマ・カンパニー・リミテッド 新規なアシル化インスリンアナログ
CN118139875A (zh) 2021-06-25 2024-06-04 甘李药业股份有限公司 含酰化胰岛素的药物组合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008241A (en) 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DK257988D0 (da) 1988-05-11 1988-05-11 Novo Industri As Nye peptider
US5149777A (en) 1988-07-20 1992-09-22 Novo Nordisk A/S Human insulin analogs and preparations containing them
AU641631B2 (en) 1988-12-23 1993-09-30 Novo Nordisk A/S Human insulin analogues
RO112873B1 (ro) * 1993-09-17 1998-01-30 Novo Nordisk As Derivati de insulina
CN1195777A (zh) 1997-05-28 1998-10-14 姚维明 电力拖动实验仪
HUP0203475A3 (en) * 1999-12-29 2005-11-28 Novo Nordisk As Method for making insulin precursors and insulin precursor analogs
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6770625B2 (en) * 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7193035B2 (en) 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
CN1780854A (zh) 2003-04-29 2006-05-31 伊莱利利公司 具有延长时间作用的胰岛素类似物
ES2402592T3 (es) * 2003-08-05 2013-05-07 Novo Nordisk A/S Nuevos derivados de insulina
KR101159559B1 (ko) * 2003-08-05 2012-06-26 노보 노르디스크 에이/에스 신규의 인슐린 유도체
CN101721712A (zh) * 2008-10-21 2010-06-09 何明磊 一种双链聚乙二醇-胰岛素复合物及其制备方法

Also Published As

Publication number Publication date
JP6153206B2 (ja) 2017-06-28
AU2012350586B2 (en) 2017-02-02
CN104788556A (zh) 2015-07-22
AU2012350586A1 (en) 2014-07-03
ZA201404417B (en) 2016-07-27
US20140329745A1 (en) 2014-11-06
EP2784085A1 (en) 2014-10-01
CN103443122B (zh) 2016-05-11
BR112014013483A2 (pt) 2019-09-24
MX2014006698A (es) 2014-07-09
TW201323439A (zh) 2013-06-16
KR20140104994A (ko) 2014-08-29
CN103443122A (zh) 2013-12-11
WO2013086927A1 (zh) 2013-06-20
HK1188795A1 (zh) 2014-05-16
CA2858253A1 (en) 2013-06-20
US9458219B2 (en) 2016-10-04
EP2784085A4 (en) 2015-07-08
JP2015501819A (ja) 2015-01-19
RU2014127270A (ru) 2016-02-10

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