IN2014DN11275A - - Google Patents

Download PDF

Info

Publication number
IN2014DN11275A
IN2014DN11275A IN11275DEN2014A IN2014DN11275A IN 2014DN11275 A IN2014DN11275 A IN 2014DN11275A IN 11275DEN2014 A IN11275DEN2014 A IN 11275DEN2014A IN 2014DN11275 A IN2014DN11275 A IN 2014DN11275A
Authority
IN
India
Prior art keywords
lipid
purified
typically
cell wall
wall component
Prior art date
Application number
Inventor
Carl Baumeister
Walter Allen Shaw
Jan Adrianus Verschoor
Original Assignee
Univ Pretoria
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pretoria filed Critical Univ Pretoria
Publication of IN2014DN11275A publication Critical patent/IN2014DN11275A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A liposomal composition comprising a sterol modified lipid and a purified mycobacterial lipid cell wall component or analog or derivative thereof is described. The composition is useful as a lipid antigen presenting vehicle for the detection of lipid antigen specific biomarker antibodies in antibody containing biological samples in the diagnosis of active tuberculosis. The purified lipid cell wall component is typically a purified mycolic acid or a mixture of mycolic acids from a mycobacterium that produces mycolic acids. The sterol modified lipid is typically a phospholipid.
IN11275DEN2014 2012-06-11 2013-06-07 IN2014DN11275A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA201204273 2012-06-11
PCT/IB2013/054686 WO2013186679A1 (en) 2012-06-11 2013-06-07 A liposomal composition comprising a sterol-modified lipid and a purified mycobacterial lipid cell wall component and it's use in the diagnosis of tuberculosis

Publications (1)

Publication Number Publication Date
IN2014DN11275A true IN2014DN11275A (en) 2015-10-09

Family

ID=48914374

Family Applications (1)

Application Number Title Priority Date Filing Date
IN11275DEN2014 IN2014DN11275A (en) 2012-06-11 2013-06-07

Country Status (7)

Country Link
US (1) US10228371B2 (en)
EP (1) EP2859345B1 (en)
CN (1) CN104685358B (en)
AP (1) AP2015008200A0 (en)
IN (1) IN2014DN11275A (en)
WO (1) WO2013186679A1 (en)
ZA (1) ZA201500130B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10551391B2 (en) * 2013-05-16 2020-02-04 University Of Pretoria Method of diagnosing tuberculosis
WO2014210327A1 (en) * 2013-06-27 2014-12-31 The Brigham And Women's Hospital, Inc. Methods and systems for determining m. tuberculosis infection
GB201414369D0 (en) 2014-08-13 2014-09-24 Univ Bangor Kit and method
KR20170102344A (en) 2015-01-05 2017-09-08 케이 인터네셔널 리미티드 How to Detect Active Tuberculosis Markers
GB201514415D0 (en) * 2015-08-13 2015-09-30 Univ Bangor Compositions and methods
CN108496081A (en) * 2015-11-06 2018-09-04 比勒陀利亚大学 Core element for real-time test lungy diagnosis
US10337032B2 (en) 2016-02-01 2019-07-02 The University Of Manchester Compositions and methods for recombinant biosynthesis of propane
NL2016301B1 (en) * 2016-02-22 2017-08-25 Kei Int Ltd Method for detecting a marker for active tuberculosis.
EP3439636B1 (en) * 2016-04-05 2023-06-07 The Research Foundation for the State University of New York Phosphoserine containing compositions for immune tolerance induction
NL2017204B1 (en) * 2016-06-08 2017-12-18 Kei International Ltd Solid substrate comprising antigens immobilised thereto, biosensor comprising said solid substrate and method for detecting the presence of mycobacterial material in a sample
WO2017211316A1 (en) 2016-06-08 2017-12-14 Kei International Limited Method for detecting the presence of mycobacterial material in a sample using at least two antigens
CN109675059A (en) * 2019-01-23 2019-04-26 青岛大学 A kind of bacteroid liposome and the preparation method and application thereof
WO2023178425A1 (en) 2022-03-23 2023-09-28 Nanovation Therapeutics Inc. High sterol-containing lipid nanoparticles
WO2024057183A1 (en) 2022-09-12 2024-03-21 University Of Pretoria Micellar mycolate coated carbon electrodes for electrochemical impedance immunoassay

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638309B2 (en) * 2003-12-03 2009-12-29 Council Of Science And Industrial Research Method for detecting pathogenic mycobacteria in clinical specimens
WO2005116654A1 (en) 2004-05-13 2005-12-08 University Of Pretoria A method for detecting mycobacterial infection
WO2009064696A1 (en) * 2007-11-14 2009-05-22 The Regents Of The University Of California Sterol-modified amphiphilic lipids
US10551391B2 (en) * 2013-05-16 2020-02-04 University Of Pretoria Method of diagnosing tuberculosis
CN108496081A (en) 2015-11-06 2018-09-04 比勒陀利亚大学 Core element for real-time test lungy diagnosis

Also Published As

Publication number Publication date
WO2013186679A1 (en) 2013-12-19
AP2015008200A0 (en) 2015-01-31
US20150111219A1 (en) 2015-04-23
CN104685358A (en) 2015-06-03
EP2859345A1 (en) 2015-04-15
US10228371B2 (en) 2019-03-12
ZA201500130B (en) 2015-12-23
CN104685358B (en) 2017-09-22
EP2859345B1 (en) 2017-07-26

Similar Documents

Publication Publication Date Title
IN2014DN11275A (en)
Kawana et al. Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS [S]
Trompette et al. Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation
Chambers et al. Serum 25-dihydroxyvitamin D levels correlate with CD4+ Foxp3+ T-cell numbers in moderate/severe asthma
EP3147372A3 (en) Versatile and sensitive biosensor
EP3955004A3 (en) Use of fatty acids in methods for detecting cancer
IN2014CN02527A (en)
WO2012122564A3 (en) Diagnostic and sample preparation devices and methods
BR112014025384A8 (en) method and system for performing automated testing and methods for performing reflective testing on multiple specimens
JP2013516179A5 (en)
Haag et al. Quantification of signaling lipids by nano-electrospray ionization tandem mass spectrometry (Nano-ESI MS/MS)
WO2014074835A3 (en) Antibody compositions and immunoassay methods to detect isoforms of anti-mullerian hormone
BR112013021666A2 (en) capacitance detection in electrochemical assay with improved sampling time compensation
AR089752A1 (en) ANTI-LRP5 ANTIBODIES AND METHODS OF USE
BR112012021590A2 (en) capacitance detection in electrochemical assay
NZ584558A (en) Peptide-lipid constructs and their use in diagnostic and therapeutic applications
DK1989544T3 (en) T-cell test method
MX2017009485A (en) Microfluidics based fetal cell detection and isolation for non-invasive prenatal testing.
GB201014837D0 (en) Biomarker signatures and uses thereof
IN2015DN00344A (en)
EA201370030A1 (en) BIFUNCTIONAL QUANTITATIVE IN VITRO ANALYSIS OF BINDING TARGETS FOR DETECTING NEUTRALIZING ANTIBODIES TO TARGET ANTIBODIES
WO2012151039A3 (en) Compositions and methods for detecting mycobacterium
Biadglegne et al. Mycobacterium tuberculosis affects protein and lipid content of circulating exosomes in infected patients depending on tuberculosis disease state
WO2012135620A3 (en) Molecular gram stain
WO2015090322A8 (en) Diagnostic reagents for improved in vivo or in vitro cell-mediated immunological diagnosis of tuberculosis