IN2014DN10439A - - Google Patents

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Publication number
IN2014DN10439A
IN2014DN10439A IN10439DEN2014A IN2014DN10439A IN 2014DN10439 A IN2014DN10439 A IN 2014DN10439A IN 10439DEN2014 A IN10439DEN2014 A IN 10439DEN2014A IN 2014DN10439 A IN2014DN10439 A IN 2014DN10439A
Authority
IN
India
Prior art keywords
copolymer
metal
metal catalyst
biodegradable
less
Prior art date
Application number
Inventor
Arimura Hidetoshi
Takahashi Yoshitake
Yamauchi Koji
Original Assignee
Gunze Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2006178808A external-priority patent/JP5354844B2/en
Priority claimed from JP2006178805A external-priority patent/JP5334360B2/en
Application filed by Gunze Kk filed Critical Gunze Kk
Publication of IN2014DN10439A publication Critical patent/IN2014DN10439A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • C08G63/82—Preparation processes characterised by the catalyst used
    • C08G63/823—Preparation processes characterised by the catalyst used for the preparation of polylactones or polylactides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/78—Preparation processes
    • C08G63/82—Preparation processes characterised by the catalyst used
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/16—Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable

Abstract

The present invention provides a safe biodegradable and bioabsorbable polymer having an extremely low metal catalyst content, while retaining the properties desired for a medical implant or the like; and a process for producing the same. The present invention further provides a method for reducing the content of a metal catalyst in a biodegradable and absorbable polymer that can be applied on an industrial scale. A method for producing a biodegradable and bioabsorbable polymer having a metal- catalyst content of less than 1 ppm in terms of a metal comprising the steps of (1) copolymerizing lactide and Ɛ-caprolactone at a molar ratio ranging from 40/60 to 60/40 in the presence of the metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a volume ratio ranging from 25/35 to 45/55. at less than 40°C and drying the copolymer. 13. A method for producing a biodegradable and bioabsorbable polymer having a metal catalyst content of less than 1 ppm in terms of a metal comprising the steps of (1) copolymerizing lactide and Ɛ-caprolactone at a molar ratio ranging from 65/35 to 85/15 in the presence of the metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a volume ratio ranging from 45/55 to 55/45 at less -than 40°C, and drying the copolymer
IN10439DEN2014 2006-06-28 2007-06-18 IN2014DN10439A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006178808A JP5354844B2 (en) 2006-06-28 2006-06-28 Production of biodegradable absorbable polymer with low metal catalyst content
JP2006178805A JP5334360B2 (en) 2006-06-28 2006-06-28 Production of biodegradable absorbable polymer with low metal catalyst content
PCT/JP2007/062212 WO2008001633A1 (en) 2006-06-28 2007-06-18 Bio-degradable/absorbable polymer having reduced metal catalyst content, and process for production thereof

Publications (1)

Publication Number Publication Date
IN2014DN10439A true IN2014DN10439A (en) 2015-08-21

Family

ID=38845401

Family Applications (1)

Application Number Title Priority Date Filing Date
IN10439DEN2014 IN2014DN10439A (en) 2006-06-28 2007-06-18

Country Status (11)

Country Link
US (2) US20090171064A1 (en)
EP (1) EP2039714B1 (en)
KR (1) KR101102475B1 (en)
AU (1) AU2007264560B2 (en)
BR (1) BRPI0713060A2 (en)
CA (1) CA2653295C (en)
HK (1) HK1129123A1 (en)
IN (1) IN2014DN10439A (en)
NZ (1) NZ573125A (en)
TW (1) TWI440651B (en)
WO (1) WO2008001633A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0329654D0 (en) 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
CA2619552A1 (en) * 2005-08-18 2007-02-22 Smith & Nephew, Plc Multimodal high strength devices and composites
EP1922091A2 (en) * 2005-08-18 2008-05-21 Smith & Nephew, PLC High strength devices and composites
DE602007011671D1 (en) 2006-11-30 2011-02-10 Smith & Nephew Inc FIBER REINFORCED COMPOSITE MATERIAL
EP2142353A1 (en) 2007-04-18 2010-01-13 Smith & Nephew PLC Expansion moulding of shape memory polymers
JP5680957B2 (en) 2007-04-19 2015-03-04 スミス アンド ネフュー インコーポレーテッドＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ，Ｉｎｃ． Graft fixation
JP5520814B2 (en) 2007-04-19 2014-06-11 スミス アンド ネフュー インコーポレーテッド Multimodal shape memory polymer
GB0715376D0 (en) * 2007-08-07 2007-09-19 Smith & Nephew Coating
JP6242382B2 (en) 2013-04-12 2017-12-06 国立大学法人京都工芸繊維大学 Method for producing lactide-lactone copolymer
CN104983484B (en) * 2015-05-26 2018-07-24 无锡市第二人民医院 It is a kind of to be implanted into high resiliency support arm degradable biological valve system and preparation and application through conduit
JP7374081B2 (en) 2017-08-31 2023-11-06 エボニック コーポレイション Improved method for purifying resorbable polymers
GB2568526A (en) * 2017-11-20 2019-05-22 Rebio Tech Oy Composition
US20210395449A1 (en) * 2018-11-27 2021-12-23 Evonik Operations Gmbh Process for preparing a resorbable polyester as a granulate or powder by bulk polymerization
CN112940234B (en) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 Preparation method of high-purity poly (glycolide-lactide)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045418A (en) * 1975-01-28 1977-08-30 Gulf Oil Corporation Copolymers of D,L-lactide and epsilon caprolactone
US4643734A (en) 1983-05-05 1987-02-17 Hexcel Corporation Lactide/caprolactone polymer, method of making the same, composites thereof, and prostheses produced therefrom
DE3641692A1 (en) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg CATALYST-FREE RESORBABLE HOMOPOLYMERS AND COPOLYMERS
DE3708916A1 (en) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg METHOD FOR CLEANING RESORBABLE POLYESTERS
NL9001984A (en) 1990-09-10 1992-04-01 Stamicarbon METHOD FOR PRODUCING AN ARTICLE OF A COPOLYMER OF LACTIDE AND EPSILON CAPROLACTONE FOR MEDICAL APPLICATIONS.
IT1249045B (en) * 1991-02-21 1995-02-11 Himont Inc SOLID STATE SYNTHESIS PROCESS OF LACTIC ACID POLYMERS AND PRODUCTS SO OBTAINED
JP3184680B2 (en) * 1992-10-09 2001-07-09 三井化学株式会社 Purification method of polyhydroxycarboxylic acid
JPH06116381A (en) * 1992-10-09 1994-04-26 Mitsui Toatsu Chem Inc Method for purifying polyhydroxycarboxylic acid
JP3273821B2 (en) * 1993-03-02 2002-04-15 三井化学株式会社 Purification method of polyhydroxycarboxylic acid
JP3622327B2 (en) * 1996-03-28 2005-02-23 トヨタ自動車株式会社   Cleaning method for aliphatic polyester pellets
JP3453648B2 (en) 1998-12-26 2003-10-06 株式会社ビーエムジー Biodegradable and absorbable polymer having low metal content and method for producing the same.
EP1334990A1 (en) * 2002-02-06 2003-08-13 Polyganics B.V. DL-Lactide-epsilon-caprolactone copolymers
JP4659451B2 (en) * 2004-12-28 2011-03-30 グンゼ株式会社 Biodegradable absorbable polymer with low content of metal catalyst and process
JP2007070413A (en) * 2005-09-05 2007-03-22 Teijin Ltd Polylactic acid composition and method for producing the same

Also Published As

Publication number Publication date
AU2007264560B2 (en) 2011-12-01
US20130066042A1 (en) 2013-03-14
EP2039714A4 (en) 2010-12-29
KR101102475B1 (en) 2012-01-05
WO2008001633A1 (en) 2008-01-03
TW200806704A (en) 2008-02-01
US20090171064A1 (en) 2009-07-02
HK1129123A1 (en) 2009-11-20
BRPI0713060A2 (en) 2012-04-10
CA2653295C (en) 2014-03-11
TWI440651B (en) 2014-06-11
EP2039714B1 (en) 2015-03-04
AU2007264560A1 (en) 2008-01-03
EP2039714A1 (en) 2009-03-25
NZ573125A (en) 2011-12-22
KR20090023599A (en) 2009-03-05
US8481673B2 (en) 2013-07-09
CA2653295A1 (en) 2008-01-03

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