IN2014DN09922A - - Google Patents

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Publication number
IN2014DN09922A
IN2014DN09922A IN9922DEN2014A IN2014DN09922A IN 2014DN09922 A IN2014DN09922 A IN 2014DN09922A IN 9922DEN2014 A IN9922DEN2014 A IN 9922DEN2014A IN 2014DN09922 A IN2014DN09922 A IN 2014DN09922A
Authority
IN
India
Prior art keywords
bcn
amino acid
relates
group
ylmethanol
Prior art date
Application number
Other languages
English (en)
Inventor
Jason Chin
Kathrin Lang
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1208875.3A external-priority patent/GB201208875D0/en
Priority claimed from GBGB1210303.2A external-priority patent/GB201210303D0/en
Application filed by Medical Res Council filed Critical Medical Res Council
Publication of IN2014DN09922A publication Critical patent/IN2014DN09922A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13Labelling of peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2/00Peptides of undefined number of amino acids; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y601/00Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/01026Pyrrolysine-tRNAPyl ligase (6.1.1.26)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/24All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IN9922DEN2014 2012-05-18 2013-05-15 IN2014DN09922A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1208875.3A GB201208875D0 (en) 2012-05-18 2012-05-18 Methods
GBGB1210303.2A GB201210303D0 (en) 2012-06-08 2012-06-08 Polypeptides and methods
PCT/GB2013/051249 WO2013171485A1 (en) 2012-05-18 2013-05-15 Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase.

Publications (1)

Publication Number Publication Date
IN2014DN09922A true IN2014DN09922A (es) 2015-08-14

Family

ID=48748281

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9922DEN2014 IN2014DN09922A (es) 2012-05-18 2013-05-15

Country Status (9)

Country Link
US (3) US20150148525A1 (es)
EP (1) EP2852664B1 (es)
JP (1) JP6343604B2 (es)
CN (2) CN104718285A (es)
BR (1) BR112014028588B1 (es)
CA (1) CA2873793C (es)
HK (1) HK1208704A1 (es)
IN (1) IN2014DN09922A (es)
WO (1) WO2013171485A1 (es)

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CN104718285A (zh) * 2012-05-18 2015-06-17 医药研究委员会 利用编码包含BCN基团的氨基酸的正交密码子和正交PylRS合成酶将包含BCN基团的氨基酸整合到多肽中的方法
CN106010507A (zh) * 2013-12-31 2016-10-12 深圳先进技术研究院 由染料分子标记的四嗪探针及其制备方法和应用
GB2528227A (en) 2014-03-14 2016-01-20 Medical Res Council Cyclopropene amino acids and methods
US20190077776A1 (en) * 2015-04-30 2019-03-14 Oregon State University Reagents and methods for bioorthogonal labeling of biomolecules in living cells
EP3360960A4 (en) 2015-08-19 2019-03-20 Riken ANTIBODIES WITH INGREDIENTS OF NON-NATURAL AMINO ACID
CN105254655B (zh) * 2015-11-20 2017-03-22 江汉大学 一种基于bodipy的荧光氨基酸及其合成方法与应用
CN106565762B (zh) * 2016-11-17 2018-10-23 陕西师范大学 一种原位产生近红外荧光的bodipy类染料及其制备和应用
KR20200007776A (ko) 2017-03-22 2020-01-22 제넨테크, 인크. 히드로겔 가교된 히알루론산 전구약물 조성물 및 방법
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
US11560384B2 (en) 2017-05-04 2023-01-24 University Of Utah Research Foundation Benzonorbornadiene derivatives and reactions thereof
AR111963A1 (es) * 2017-05-26 2019-09-04 Univ California Método y moléculas
TW202027794A (zh) 2018-10-03 2020-08-01 瑞士商諾華公司 血管生成素樣3多肽之持續遞送
CN111849929B (zh) * 2019-04-30 2021-05-11 苏州鲲鹏生物技术有限公司 高效引入赖氨酸衍生物的氨酰基—tRNA合成酶
IL267744A (en) * 2019-06-30 2019-08-29 Nat Inst Biotechnology Negev Ltd Labelling molecules and methods of use thereof
CN115701451B (zh) * 2021-08-02 2023-08-01 宁波鲲鹏生物科技有限公司 高效引入赖氨酸衍生物的氨酰基-tRNA合成酶及其应用

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EP2378288B1 (en) 2003-06-18 2015-09-09 The Scripps Research Institute Unnatural reactive amino acid genetic code additions
PT1914314E (pt) * 2003-07-07 2010-09-08 Scripps Research Inst Composições de pares ortogonais de lisil-arnt e aminoacil-arnt-sintetase e suas utilizações
WO2006001832A2 (en) 2003-12-18 2006-01-05 The Scripps Research Institute Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells
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WO2006110182A2 (en) 2004-10-27 2006-10-19 The Scripps Research Institute Orthogonal translation components for the in vivo incorporation of unnatural amino acids
JP2007037445A (ja) 2005-08-02 2007-02-15 Institute Of Physical & Chemical Research tRNA合成方法、核酸、アミノアシルtRNA合成方法及び非天然型アミノ酸組み込み蛋白質の製造方法
US20090081669A1 (en) 2006-02-01 2009-03-26 Encode Bio, Inc. Fluorescent Assays Using Orthogonal tRNA - Aminoacyl Synthetase Pairs
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AU2008301614A1 (en) * 2007-09-20 2009-03-26 Riken Mutant pyrrolysyl-TRNA synthetase, and method for production of protein having non-natural amino acid integrated therein by using the same
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CN104718285A (zh) * 2012-05-18 2015-06-17 医药研究委员会 利用编码包含BCN基团的氨基酸的正交密码子和正交PylRS合成酶将包含BCN基团的氨基酸整合到多肽中的方法
SG11201501464TA (en) 2012-08-31 2015-03-30 Sutro Biopharma Inc Modified amino acids comprising an azido group
BR112015006368B1 (pt) 2012-09-24 2022-02-08 Medimmune Limited Processo para produção de linha celular eucariótica estável
GB2528227A (en) 2014-03-14 2016-01-20 Medical Res Council Cyclopropene amino acids and methods
GB201419109D0 (en) 2014-10-27 2014-12-10 Medical Res Council Incorporation of unnatural amino acids into proteins
CN107614689A (zh) * 2015-03-27 2018-01-19 昆士兰大学 用于将非天然氨基酸并入蛋白质中的平台
GB201817444D0 (en) 2018-10-26 2018-12-12 Res & Innovation Uk Methods and compositions
EP3868882A1 (en) * 2020-02-21 2021-08-25 European Molecular Biology Laboratory Archaeal pyrrolysyl trna synthetases for orthogonal use

Also Published As

Publication number Publication date
JP6343604B2 (ja) 2018-06-13
US20150148525A1 (en) 2015-05-28
CA2873793C (en) 2022-02-22
US11732001B2 (en) 2023-08-22
HK1208704A1 (en) 2016-03-11
CN104718285A (zh) 2015-06-17
JP2015523965A (ja) 2015-08-20
CA2873793A1 (en) 2013-11-21
BR112014028588A2 (pt) 2017-06-27
CN108410827A (zh) 2018-08-17
EP2852664B1 (en) 2017-09-06
US20200271658A1 (en) 2020-08-27
WO2013171485A1 (en) 2013-11-21
BR112014028588A8 (pt) 2021-06-29
CN108410827B (zh) 2023-05-09
EP2852664A1 (en) 2015-04-01
BR112014028588B1 (pt) 2023-03-21
US20230340013A1 (en) 2023-10-26

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