IN2014DN09026A - - Google Patents
Info
- Publication number
- IN2014DN09026A IN2014DN09026A IN9026DEN2014A IN2014DN09026A IN 2014DN09026 A IN2014DN09026 A IN 2014DN09026A IN 9026DEN2014 A IN9026DEN2014 A IN 9026DEN2014A IN 2014DN09026 A IN2014DN09026 A IN 2014DN09026A
- Authority
- IN
- India
- Prior art keywords
- easy
- reaction
- purified
- preparation
- appropriate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
Abstract
The present invention relates to a process of a chemically synthetic drug and in particular to a new intermediate of a heparin pentasaccharide and a preparation method thereof. The process has high reaction efficiency and an easy reaction operation. The reaction intermediate is easy to be purified and is appropriate for an industrialization production.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210102415.0A CN103360439B (en) | 2012-04-02 | 2012-04-02 | Prepare new intermediate of heparin pentasaccharides and preparation method thereof |
PCT/CN2013/073601 WO2013149576A1 (en) | 2012-04-02 | 2013-04-02 | Preparation of new intermediate of heparin pentasaccharide and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014DN09026A true IN2014DN09026A (en) | 2015-05-22 |
Family
ID=49299997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN9026DEN2014 IN2014DN09026A (en) | 2012-04-02 | 2013-04-02 |
Country Status (6)
Country | Link |
---|---|
US (1) | US9624315B2 (en) |
EP (1) | EP2837635B1 (en) |
JP (1) | JP2015514098A (en) |
CN (1) | CN103360439B (en) |
IN (1) | IN2014DN09026A (en) |
WO (1) | WO2013149576A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102718808A (en) * | 2012-06-04 | 2012-10-10 | 浙江星月药物科技股份有限公司 | Methods for preparing class-one polysaccharide derivative and intermediate of class-one polysaccharide derivative |
CN103570774B (en) * | 2012-08-07 | 2017-08-25 | 博瑞生物医药(苏州)股份有限公司 | A kind of purification process of pentose compound |
CN103992364B (en) * | 2014-03-25 | 2016-08-10 | 南京天翔医药科技有限公司 | A kind of separating and extracting process of Fondaparinux sodium |
CN103965269B (en) * | 2014-04-16 | 2018-05-04 | 杭州华东医药集团新药研究院有限公司 | Fondaparinux sodium of low moisture high-purity and preparation method thereof |
CN104098618A (en) * | 2014-07-25 | 2014-10-15 | 河北常山生化药业股份有限公司 | Intermediate of fondaparinux sodium and preparation method for intermediate and fondaparinux sodium |
CN105037452B (en) * | 2015-06-19 | 2018-10-09 | 天津红日药业股份有限公司 | A kind of process for purification of quick preparation high-purity Fondaparinux sodium |
JP6741277B2 (en) * | 2015-12-30 | 2020-08-19 | シェンツェン ヘパリンク ファーマスーティカル グループ カンパニー リミテッドShenzhen Hepalink Pharmaceutical Group Co., Ltd. | Sulfated heparin-derived oligosaccharide and its preparation method and application |
CN108148101B (en) * | 2016-12-03 | 2021-12-24 | 烟台东诚药业集团股份有限公司 | Novel process method for preparing fondaparinux sodium |
CN115057896A (en) * | 2022-07-28 | 2022-09-16 | 苏州柯默拓医药科技有限公司 | Synthetic method of fondaparinux sodium |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4818816A (en) * | 1981-04-28 | 1989-04-04 | Choay, S.A. | Process for the organic synthesis of oligosaccharides and derivatives thereof |
EP0300099A1 (en) | 1987-07-20 | 1989-01-25 | Akzo N.V. | New pentasaccharides |
AU2002331426B2 (en) * | 2001-09-07 | 2008-01-10 | Dr. Reddy's Laboratories Sa | Synthetic heparin pentasaccharides |
EP2421877A4 (en) * | 2008-10-03 | 2013-03-20 | Glycan Biosciences Llc | Anionic conjugates of glycosylated bacterial metabolite |
ES2336297B1 (en) | 2008-10-08 | 2011-01-24 | Laboratorios Farmaceuticos Rovi, S.A. | PENTASACARIDOS SYNTHESIS PROCEDURE DEPROTECTED FROM A PENTASACARIDO PRECURSOS PROTECTED. |
JP2012106933A (en) * | 2009-03-10 | 2012-06-07 | Univ Of Tokyo | Oligo-aminosaccharide compound |
ES2939741T3 (en) * | 2009-07-31 | 2023-04-26 | Reliable Biopharmaceutical Llc | Process for preparing fondaparinux sodium and useful intermediates in the synthesis thereof |
CN102718808A (en) * | 2012-06-04 | 2012-10-10 | 浙江星月药物科技股份有限公司 | Methods for preparing class-one polysaccharide derivative and intermediate of class-one polysaccharide derivative |
-
2012
- 2012-04-02 CN CN201210102415.0A patent/CN103360439B/en not_active Expired - Fee Related
-
2013
- 2013-04-02 JP JP2015503738A patent/JP2015514098A/en active Pending
- 2013-04-02 WO PCT/CN2013/073601 patent/WO2013149576A1/en active Application Filing
- 2013-04-02 IN IN9026DEN2014 patent/IN2014DN09026A/en unknown
- 2013-04-02 EP EP13772346.6A patent/EP2837635B1/en not_active Not-in-force
- 2013-04-02 US US14/389,806 patent/US9624315B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US9624315B2 (en) | 2017-04-18 |
EP2837635A4 (en) | 2015-05-27 |
CN103360439A (en) | 2013-10-23 |
JP2015514098A (en) | 2015-05-18 |
WO2013149576A1 (en) | 2013-10-10 |
EP2837635A1 (en) | 2015-02-18 |
CN103360439B (en) | 2017-12-15 |
EP2837635B1 (en) | 2017-10-18 |
US20150299340A1 (en) | 2015-10-22 |
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