IN2014DN08236A - - Google Patents
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- IN2014DN08236A IN2014DN08236A IN8236DEN2014A IN2014DN08236A IN 2014DN08236 A IN2014DN08236 A IN 2014DN08236A IN 8236DEN2014 A IN8236DEN2014 A IN 8236DEN2014A IN 2014DN08236 A IN2014DN08236 A IN 2014DN08236A
- Authority
- IN
- India
- Prior art keywords
- fusion molecules
- ifn
- present
- engineered
- fusion
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Abstract
The field of the present invention relates to genetically engineered fusion molecules methods of making said fusion molecules and uses thereof in anti tumor immunotherapies. More specifically the present invention relates to fusion molecule constructs wherein a tumor associated antigen (TAA) antibody (Ab) serves as a targeting moiety to selectively deliver a cytokine to a tumor cell for purposes of killing or inhibiting the growth or proliferation of said tumor cell. In various embodiments the engineered fusion molecules comprise a TAA Ab fused to an interferon alpha (IFN a) mutant molecule. The engineered Ab IFN a mutant fusion molecules of the present invention demonstrate improved therapeutic index and preserved or increased efficacy as compared to Ab wildtype IFN a fusion molecules and/or demonstrate improved PK properties as compared to Ab wildtype IFN a fusion molecules.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261634565P | 2012-03-03 | 2012-03-03 | |
PCT/US2013/028899 WO2013134138A1 (en) | 2012-03-03 | 2013-03-04 | Engineered antibody-interferon mutant fusion molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014DN08236A true IN2014DN08236A (en) | 2015-05-15 |
Family
ID=49042962
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN8236DEN2014 IN2014DN08236A (en) | 2012-03-03 | 2013-03-04 |
Country Status (15)
Country | Link |
---|---|
US (3) | US8980267B2 (en) |
EP (2) | EP2822575B1 (en) |
JP (1) | JP6195855B2 (en) |
CN (1) | CN104470536A (en) |
AU (1) | AU2013230484B2 (en) |
CA (1) | CA2866126A1 (en) |
DK (1) | DK2822575T3 (en) |
ES (1) | ES2800426T3 (en) |
HR (1) | HRP20200918T1 (en) |
HU (1) | HUE049945T2 (en) |
IN (1) | IN2014DN08236A (en) |
LT (1) | LT2822575T (en) |
PL (1) | PL2822575T3 (en) |
PT (1) | PT2822575T (en) |
WO (1) | WO2013134138A1 (en) |
Families Citing this family (50)
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EP2853267B1 (en) * | 2007-09-21 | 2016-12-07 | The Regents of the University of California | Targeted interferon demonstrates potent apoptotic and anti-tumor activities |
HUE035281T2 (en) | 2011-01-14 | 2018-05-02 | Univ California | Therapeutic antibodies against ror-1 protein and methods for use of same |
JP6184965B2 (en) | 2011-10-28 | 2017-08-23 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | Polypeptide constructs and uses thereof |
EP2804877B1 (en) | 2012-01-20 | 2018-08-22 | VIB vzw | Targeted mutant alpha-helical bundle cytokines |
US9803021B2 (en) | 2012-12-07 | 2017-10-31 | The Regents Of The University Of California | CD138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
AU2013388126B2 (en) | 2013-04-29 | 2019-03-07 | Teva Pharmaceuticals Australia Pty Ltd. | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2b |
WO2014194100A1 (en) | 2013-05-29 | 2014-12-04 | The Regents Of The University Of California | Anti-cspg4 fusions with interferon for the treatment of malignancy |
CN110835376B (en) | 2013-07-18 | 2023-08-04 | 弗拉芒区生物技术研究所 | Fusion factors involving cytokines with strongly reduced receptor binding affinities |
ES2686668T3 (en) | 2013-07-19 | 2018-10-19 | Vib Vzw | Targeted modified TNF family members |
KR102305608B1 (en) | 2013-07-19 | 2021-09-28 | 브이아이비 브이지더블유 | Targeting of cytokine antagonists |
SG11201600167SA (en) | 2013-07-19 | 2016-02-26 | Vib Vzw | Targeted modified il-1 family members |
CN104193828B (en) * | 2013-09-12 | 2017-04-05 | 北京韩美药品有限公司 | The recombination fusion protein of HER2 and VEGFR signal paths is blocked simultaneously |
WO2015168474A1 (en) | 2014-04-30 | 2015-11-05 | President And Fellows Of Harvard College | Fusion proteins for treating cancer and related methods |
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EP3212216A4 (en) * | 2014-10-29 | 2018-04-18 | Teva Pharmaceuticals Australia Pty Ltd | Interferon alpha2b variants |
AU2016274897B2 (en) * | 2015-06-12 | 2021-02-25 | Immungene, Inc. | Focused interferon immunotherapy for treatment of cancer |
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US20190008983A1 (en) * | 2015-07-31 | 2019-01-10 | James R. Prudent | Extracellular drug conjugates targeting cd20 |
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WO2017091611A1 (en) * | 2015-11-23 | 2017-06-01 | Immungene, Inc | Enhanced cancer immunotherapy using antibody-interferon fusion molecules |
US11661455B2 (en) | 2016-02-05 | 2023-05-30 | Orionis Biosciences BV | Chimeric protein comprising an interferon alpha 2mutant and a PD-L1 binding moiety |
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WO2017173359A2 (en) * | 2016-03-31 | 2017-10-05 | University Of Southern California | Methods of constructing immunoglobulin fusion proteins inhibiting cathepsin b and compositions thereof |
WO2017180764A1 (en) * | 2016-04-12 | 2017-10-19 | Immungene, Inc. | Focused interferon immunotherapy |
EP3454887B1 (en) | 2016-05-13 | 2021-01-20 | Orionis Biosciences BV | Targeted mutant interferon-beta and uses thereof |
CN109563141A (en) | 2016-05-13 | 2019-04-02 | 奥里尼斯生物科学公司 | To the therapeutic targeting of cellular structures |
CA3040802A1 (en) | 2016-10-24 | 2018-05-03 | Orionis Biosciences Nv | Targeted mutant interferon-gamma and uses thereof |
CN106854248A (en) * | 2016-12-09 | 2017-06-16 | 中国药科大学 | A kind of preparation and its application of cell factor mutant fusion antibody |
WO2018144999A1 (en) | 2017-02-06 | 2018-08-09 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
MX2019009255A (en) | 2017-02-06 | 2019-11-05 | Orionis Biosciences Nv | Targeted chimeric proteins and uses thereof. |
US11246911B2 (en) | 2017-02-07 | 2022-02-15 | Vib Vzw | Immune-cell targeted bispecific chimeric proteins and uses thereof |
CN111386347A (en) * | 2017-06-21 | 2020-07-07 | 北卡罗来纳大学教堂山分校 | Methods and compositions for targeting chimeric antigen receptors of cancer cells |
WO2019010224A1 (en) * | 2017-07-03 | 2019-01-10 | Torque Therapeutics, Inc. | Fusion molecules targeting immune regulatory cells and uses thereof |
EP3658186A4 (en) * | 2017-07-24 | 2020-08-12 | Rutgers, The State University of New Jersey | Phosphatidylserine targeting fusion molecules and methods for their use |
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JP7423511B2 (en) | 2017-08-09 | 2024-01-29 | オリオンズ バイオサイエンス インコーポレイテッド | PD-1 and PD-L1 binding substances |
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CN107556376B (en) * | 2017-09-08 | 2018-09-28 | 上海华新生物高技术有限公司 | A kind of Interferon Alpha-2b mutant and its preparation method and application |
JP2021519089A (en) * | 2018-03-28 | 2021-08-10 | オリオニス バイオサイエンシーズ,インコーポレイテッド | Bifunctional protein and its preparation |
CN111499718B (en) * | 2019-01-30 | 2022-06-14 | 复旦大学 | Human alpha interferon receptor binding related site mutant and application thereof |
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EP2853267B1 (en) * | 2007-09-21 | 2016-12-07 | The Regents of the University of California | Targeted interferon demonstrates potent apoptotic and anti-tumor activities |
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ES2611479T3 (en) | 2010-06-16 | 2017-05-09 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Endoplasmin antibodies and their use |
JP6184965B2 (en) | 2011-10-28 | 2017-08-23 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | Polypeptide constructs and uses thereof |
EP2804877B1 (en) | 2012-01-20 | 2018-08-22 | VIB vzw | Targeted mutant alpha-helical bundle cytokines |
US9803021B2 (en) | 2012-12-07 | 2017-10-31 | The Regents Of The University Of California | CD138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
AU2013388126B2 (en) | 2013-04-29 | 2019-03-07 | Teva Pharmaceuticals Australia Pty Ltd. | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2b |
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2013
- 2013-03-04 EP EP13758471.0A patent/EP2822575B1/en active Active
- 2013-03-04 JP JP2014560996A patent/JP6195855B2/en active Active
- 2013-03-04 PL PL13758471T patent/PL2822575T3/en unknown
- 2013-03-04 EP EP20162413.7A patent/EP3799880A3/en not_active Withdrawn
- 2013-03-04 ES ES13758471T patent/ES2800426T3/en active Active
- 2013-03-04 AU AU2013230484A patent/AU2013230484B2/en not_active Ceased
- 2013-03-04 LT LTEP13758471.0T patent/LT2822575T/en unknown
- 2013-03-04 HU HUE13758471A patent/HUE049945T2/en unknown
- 2013-03-04 WO PCT/US2013/028899 patent/WO2013134138A1/en active Application Filing
- 2013-03-04 US US13/784,049 patent/US8980267B2/en active Active
- 2013-03-04 PT PT137584710T patent/PT2822575T/en unknown
- 2013-03-04 IN IN8236DEN2014 patent/IN2014DN08236A/en unknown
- 2013-03-04 CN CN201380023287.3A patent/CN104470536A/en active Pending
- 2013-03-04 DK DK13758471.0T patent/DK2822575T3/en active
- 2013-03-04 CA CA2866126A patent/CA2866126A1/en not_active Abandoned
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2015
- 2015-02-02 US US14/611,945 patent/US9534057B2/en active Active
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2016
- 2016-11-28 US US15/361,902 patent/US10259854B2/en not_active Expired - Fee Related
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2020
- 2020-06-08 HR HRP20200918TT patent/HRP20200918T1/en unknown
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WO2013134138A1 (en) | 2013-09-12 |
EP2822575A4 (en) | 2016-07-06 |
US10259854B2 (en) | 2019-04-16 |
AU2013230484B2 (en) | 2017-04-27 |
EP2822575B1 (en) | 2020-05-06 |
LT2822575T (en) | 2020-06-25 |
US9534057B2 (en) | 2017-01-03 |
DK2822575T3 (en) | 2020-06-15 |
JP6195855B2 (en) | 2017-09-13 |
PT2822575T (en) | 2020-07-02 |
HUE049945T2 (en) | 2020-11-30 |
HRP20200918T1 (en) | 2020-11-27 |
JP2015515453A (en) | 2015-05-28 |
CN104470536A (en) | 2015-03-25 |
EP3799880A2 (en) | 2021-04-07 |
CA2866126A1 (en) | 2013-09-12 |
ES2800426T3 (en) | 2020-12-30 |
US20130230517A1 (en) | 2013-09-05 |
US20150139951A1 (en) | 2015-05-21 |
EP2822575A1 (en) | 2015-01-14 |
US8980267B2 (en) | 2015-03-17 |
AU2013230484A1 (en) | 2015-02-12 |
US20170073388A1 (en) | 2017-03-16 |
EP3799880A3 (en) | 2021-06-23 |
PL2822575T3 (en) | 2020-08-10 |
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