IN2014DN06904A - - Google Patents
Info
- Publication number
- IN2014DN06904A IN2014DN06904A IN6904DEN2014A IN2014DN06904A IN 2014DN06904 A IN2014DN06904 A IN 2014DN06904A IN 6904DEN2014 A IN6904DEN2014 A IN 6904DEN2014A IN 2014DN06904 A IN2014DN06904 A IN 2014DN06904A
- Authority
- IN
- India
- Prior art keywords
- ang2
- ang2 binding
- binding molecules
- vhhs
- angiogenesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3038—Kidney, bladder
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gynecology & Obstetrics (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Ang2 binding molecules preferably Ang2 binding immunoglobulin single variable domains like VHHs and domain antibodies pharmaceutical compositions containing same and their use in the treatment of diseases that are associated with Ang2 mediated effects on angiogenesis. Nucleic acids encoding Ang2 binding molecules host cells and methods for preparing same.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12162615 | 2012-03-30 | ||
PCT/EP2013/056635 WO2013144266A1 (en) | 2012-03-30 | 2013-03-27 | Ang2-binding molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014DN06904A true IN2014DN06904A (en) | 2015-05-15 |
Family
ID=48190468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN6904DEN2014 IN2014DN06904A (en) | 2012-03-30 | 2013-03-27 |
Country Status (27)
Country | Link |
---|---|
US (5) | US20130259859A1 (en) |
EP (1) | EP2831111B1 (en) |
JP (1) | JP5970734B2 (en) |
KR (1) | KR102020255B1 (en) |
CN (1) | CN104321344B (en) |
AU (1) | AU2013241769B2 (en) |
BR (1) | BR112014023415B1 (en) |
CA (1) | CA2865464C (en) |
CL (1) | CL2014002393A1 (en) |
CY (1) | CY1122007T1 (en) |
DK (1) | DK2831111T3 (en) |
EA (1) | EA031182B1 (en) |
ES (1) | ES2729165T3 (en) |
HR (1) | HRP20190817T1 (en) |
HU (1) | HUE044263T2 (en) |
IL (1) | IL234234B (en) |
IN (1) | IN2014DN06904A (en) |
LT (1) | LT2831111T (en) |
MX (1) | MX350248B (en) |
NZ (1) | NZ628584A (en) |
PH (1) | PH12014502179A1 (en) |
PL (1) | PL2831111T3 (en) |
PT (1) | PT2831111T (en) |
RS (1) | RS58732B1 (en) |
SI (1) | SI2831111T1 (en) |
TR (1) | TR201908638T4 (en) |
WO (1) | WO2013144266A1 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
US20170248603A1 (en) | 2014-10-06 | 2017-08-31 | Dana-Farber Cancer Institute, Inc. | Angiopoiten-2 biomarkers predictive of anti-immune checkpoint response |
AU2015331602A1 (en) | 2014-10-17 | 2017-04-27 | Amgen Inc. | Antibodies directed to angiopoietin-1 and angiopoietin-2 for ocular therapies |
CN107427577A (en) * | 2015-03-31 | 2017-12-01 | 韦斯夸尔德有限公司 | Peptidic constructs with the cleavable joint of protease |
ES2828694T3 (en) * | 2015-07-29 | 2021-05-27 | Allergan Inc | Heavy chain-only antibodies to ANG-2 |
US20190300967A1 (en) * | 2016-10-13 | 2019-10-03 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for predicting response and resistance to ctla4 blockade in melanoma using a gene expression signature |
KR102143132B1 (en) * | 2016-12-26 | 2020-08-10 | 기초과학연구원 | Composition for Preventing or Treating of Ocular Diseases Comprising Anti-Ang2 Antibody |
EP3565839A4 (en) | 2017-01-05 | 2021-04-21 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
CA3061053A1 (en) * | 2017-06-02 | 2018-12-06 | Boehringer Ingelheim International Gmbh | Anti-cancer combination therapy |
CN108659130B (en) * | 2018-05-28 | 2021-09-10 | 长春力太生物技术有限公司 | Anti-carcinoembryonic antigen nano antibody and application thereof |
EP3813864A4 (en) | 2018-06-29 | 2022-07-20 | Gensun Biopharma Inc. | Antitumor antagonists |
CN113728004A (en) * | 2019-02-25 | 2021-11-30 | 药物抗体公司 | anti-Ang 2 antibodies and uses thereof |
US20220185875A1 (en) * | 2019-03-18 | 2022-06-16 | Jiangsu Hengrui Medicine Co., Ltd. | Bispecific antibody specifically bound to vegf and ang2 |
CN114340735A (en) | 2019-06-28 | 2022-04-12 | 璟尚生物制药公司 | Antitumor antagonist composed of mutated TGF beta 1-RII extracellular domain and immunoglobulin scaffold |
CN111875706B (en) * | 2020-07-16 | 2021-03-30 | 广州康盛生物科技股份有限公司 | Single-domain antibody of anti-human IgE protein and application thereof |
US20220389120A1 (en) | 2021-06-03 | 2022-12-08 | Gensun Biopharma Inc. | Multispecific antagonists |
KR20240048555A (en) * | 2021-09-10 | 2024-04-15 | 소테르 바이오파마 피티이. 리미티드 | Anti-ANG2 antibody and its production method and application |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1589107T3 (en) | 1992-08-21 | 2010-04-26 | Univ Bruxelles | Immunuglobulins without light chains |
US5643755A (en) | 1994-10-07 | 1997-07-01 | Regeneron Pharmaceuticals Inc. | Nucleic acid encoding tie-2 ligand |
US5814464A (en) | 1994-10-07 | 1998-09-29 | Regeneron Pharma | Nucleic acids encoding TIE-2 ligand-2 |
US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
CN1268394C (en) | 2001-01-17 | 2006-08-09 | 特鲁比昂药品公司 | Binding domain-immunoglobulin fusion proteins |
DK1399484T3 (en) | 2001-06-28 | 2010-11-08 | Domantis Ltd | Double-specific ligand and its use |
US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
US7205275B2 (en) | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
EP1558647B1 (en) | 2002-11-08 | 2015-06-10 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
EP3299393A1 (en) | 2002-11-08 | 2018-03-28 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
ATE485307T1 (en) | 2003-11-07 | 2010-11-15 | Ablynx Nv | CAMELIDAE HEAVY CHAIN ANTIBODIES VHHS TO EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND THEIR USE |
US20050284249A1 (en) | 2004-06-29 | 2005-12-29 | Arnone David F | Worm type gear mover assembly |
WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
RU2394839C2 (en) | 2004-12-21 | 2010-07-20 | Астразенека Аб | Antibodies against angiopoietin-2 and use thereof |
PL1888641T3 (en) | 2005-05-18 | 2012-05-31 | Ablynx Nv | Serum albumin binding proteins |
JP2009539870A (en) | 2006-06-06 | 2009-11-19 | ジェネンテック・インコーポレーテッド | Compositions and methods for modulating angiogenesis |
EP2057191A1 (en) | 2006-08-18 | 2009-05-13 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of deseases and disorders associated with il-6-mediated signalling |
CN101663319A (en) | 2007-02-21 | 2010-03-03 | 埃博灵克斯股份有限公司 | Be used for the treatment of at the aminoacid sequence of vascular endothelial growth factor and the polypeptide that comprises it and be characterised in that excessive and/or pathologic vessels takes place or the illness and the disease of neovascularization |
US20110091462A1 (en) | 2008-03-05 | 2011-04-21 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making and uses thereof |
SI2285408T1 (en) * | 2008-06-05 | 2019-02-28 | Ablynx N.V. | Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases |
EP2364328A2 (en) * | 2008-12-10 | 2011-09-14 | Ablynx NV | Amino acid sequences directed against the angiopoietin/tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
JO3182B1 (en) * | 2009-07-29 | 2018-03-08 | Regeneron Pharma | High Affinity Human Antibodies to Human Angiopoietin-2 |
US20130078247A1 (en) * | 2011-04-01 | 2013-03-28 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to dii4 and ang2 |
US9527925B2 (en) * | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
-
2013
- 2013-03-27 IN IN6904DEN2014 patent/IN2014DN06904A/en unknown
- 2013-03-27 WO PCT/EP2013/056635 patent/WO2013144266A1/en active Application Filing
- 2013-03-27 DK DK13718796.9T patent/DK2831111T3/en active
- 2013-03-27 MX MX2014011171A patent/MX350248B/en active IP Right Grant
- 2013-03-27 AU AU2013241769A patent/AU2013241769B2/en active Active
- 2013-03-27 CA CA2865464A patent/CA2865464C/en active Active
- 2013-03-27 RS RS20190627A patent/RS58732B1/en unknown
- 2013-03-27 PT PT13718796T patent/PT2831111T/en unknown
- 2013-03-27 PL PL13718796T patent/PL2831111T3/en unknown
- 2013-03-27 BR BR112014023415-9A patent/BR112014023415B1/en active IP Right Grant
- 2013-03-27 KR KR1020147028419A patent/KR102020255B1/en active IP Right Grant
- 2013-03-27 SI SI201331449T patent/SI2831111T1/en unknown
- 2013-03-27 LT LTEP13718796.9T patent/LT2831111T/en unknown
- 2013-03-27 ES ES13718796T patent/ES2729165T3/en active Active
- 2013-03-27 EP EP13718796.9A patent/EP2831111B1/en active Active
- 2013-03-27 JP JP2015502346A patent/JP5970734B2/en active Active
- 2013-03-27 HU HUE13718796 patent/HUE044263T2/en unknown
- 2013-03-27 EA EA201401065A patent/EA031182B1/en not_active IP Right Cessation
- 2013-03-27 CN CN201380026471.3A patent/CN104321344B/en active Active
- 2013-03-27 NZ NZ628584A patent/NZ628584A/en unknown
- 2013-03-27 TR TR2019/08638T patent/TR201908638T4/en unknown
- 2013-03-28 US US13/852,402 patent/US20130259859A1/en not_active Abandoned
-
2014
- 2014-08-21 IL IL234234A patent/IL234234B/en active IP Right Grant
- 2014-09-10 CL CL2014002393A patent/CL2014002393A1/en unknown
- 2014-09-29 PH PH12014502179A patent/PH12014502179A1/en unknown
-
2016
- 2016-12-21 US US15/386,181 patent/US20170107281A1/en not_active Abandoned
-
2018
- 2018-07-02 US US16/025,067 patent/US20190135907A1/en not_active Abandoned
-
2019
- 2019-04-30 HR HRP20190817TT patent/HRP20190817T1/en unknown
- 2019-06-18 CY CY20191100625T patent/CY1122007T1/en unknown
-
2020
- 2020-03-13 US US16/817,700 patent/US20200207845A1/en not_active Abandoned
-
2023
- 2023-03-17 US US18/185,493 patent/US20230203146A1/en active Pending
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