IN2014CN04131A - - Google Patents
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- Publication number
- IN2014CN04131A IN2014CN04131A IN4131CHN2014A IN2014CN04131A IN 2014CN04131 A IN2014CN04131 A IN 2014CN04131A IN 4131CHN2014 A IN4131CHN2014 A IN 4131CHN2014A IN 2014CN04131 A IN2014CN04131 A IN 2014CN04131A
- Authority
- IN
- India
- Prior art keywords
- endopeptidases
- enzymes
- nucleic acids
- actinoallomurus
- gluten
- Prior art date
Links
- 102000005593 Endopeptidases Human genes 0.000 abstract 4
- 108010059378 Endopeptidases Proteins 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 4
- 108090000790 Enzymes Proteins 0.000 abstract 4
- 229940088598 enzyme Drugs 0.000 abstract 4
- 229940066758 endopeptidases Drugs 0.000 abstract 3
- 241000605656 Actinoallomurus Species 0.000 abstract 2
- 208000015943 Coeliac disease Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 206010012468 Dermatitis herpetiformis Diseases 0.000 abstract 1
- 108010068370 Glutens Proteins 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 235000021312 gluten Nutrition 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/346—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of vegetable proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21026—Prolyl oligopeptidase (3.4.21.26), i.e. proline-specific endopeptidase
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Peptides Or Proteins (AREA)
Abstract
The invention relates to a new family of proteolytic enxymes having the ability to hydrolize at a p H between 3 and 8 gluten olygopeptides which are resistant to cleavage by gastric and pancreatic enzymes and whose presence in the intestinal lumen results in toxic effects. The enzymes have been identified as endopeptidases of the S8/S53 family and are produced by an Actinoallomurus strain. The object of the invention includes also methods for producing enzymes composition comprising the endopeptidases by cultivation of native Actinoallomurus strains mutants thereof or recombinant host cells comprising nucleic acids codifying for the endopeptidases. Said nucleic acids constitute a further object of the invention. The enzyme compositions comprising at least one endopeptidase of the invention are useful for the treatment and/or prevention of celiac sprue dermatitis herpetiformis and any other disorder associated with gluten intolerance as ingredients of pharmaceutical formulations or as additives of foods and drinks.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11425291 | 2011-12-06 | ||
| PCT/EP2012/071816 WO2013083338A1 (en) | 2011-12-06 | 2012-11-05 | New proteases able to hydrolyze gluten peptides and proteins at acidic ph, from the actinomycete actinoallomurus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN04131A true IN2014CN04131A (en) | 2015-07-17 |
Family
ID=47137719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN4131CHN2014 IN2014CN04131A (en) | 2011-12-06 | 2012-11-05 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20140356345A1 (en) |
| EP (1) | EP2788018B1 (en) |
| JP (1) | JP6203743B2 (en) |
| CN (1) | CN104039345B (en) |
| AU (1) | AU2012348782B2 (en) |
| BR (1) | BR112014012100B1 (en) |
| CA (1) | CA2852365C (en) |
| EA (1) | EA028228B1 (en) |
| ES (1) | ES2595500T3 (en) |
| HK (1) | HK1198244A1 (en) |
| IN (1) | IN2014CN04131A (en) |
| WO (1) | WO2013083338A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2718434T3 (en) | 2011-08-10 | 2018-08-31 | University Of Washington Through Its Center For Commercialization | Compositions and methods for treating celiac sprue disease |
| EP3520808B1 (en) * | 2013-08-14 | 2021-04-21 | University Of Washington Through Its Center For Commercialization | Compositions for treating celiac sprue disease |
| US9867872B2 (en) | 2013-09-05 | 2018-01-16 | Dsm Ip Assets B.V. | Use of an acidic soft drink to enhance the efficacy of a gluten-digesting enzyme |
| CN105899543A (en) * | 2013-11-26 | 2016-08-24 | 诺维信公司 | Milling process |
| ES2791891T3 (en) * | 2014-10-24 | 2020-11-06 | Dupont Nutrition Biosci Aps | Use of proline tolerant tripeptidyl peptidases in feed additive compositions |
| JP7325030B2 (en) | 2015-06-08 | 2023-08-14 | ユニヴァーシティ オブ ワシントン | Compositions and methods for treating celiac sprue disease |
| US11124785B2 (en) | 2016-02-11 | 2021-09-21 | Trustees Of Boston University | Rothia subtilisins, S8A family proteases, as therapeutic enzymes for application in gluten intolerance disorders |
| IT201900012942A1 (en) | 2019-07-25 | 2021-01-25 | Nemysis Ltd | METHOD FOR THE PRODUCTION OF AN ENZYMATIC COMPOSITION INCLUDING A RECOMBINANT ENDOPEPTIDASE |
| US20220364069A1 (en) | 2019-07-25 | 2022-11-17 | Nemysis Limited | Method for the production of an enzymatic composition comprising a recombinant endopeptidase |
| CN111172138B (en) * | 2020-02-14 | 2022-03-25 | 江南大学 | Proteolytic enzyme and application thereof in production of protein peptide |
| IT202100018254A1 (en) | 2021-07-12 | 2023-01-12 | Nemysis Ltd | NEW SYSTEMS FOR PRODUCING RECOMBINANT PROTEINS |
| CN114438044B (en) * | 2022-01-14 | 2024-03-29 | 南昌大学 | Multienzyme complex for efficiently degrading gluten protein and application thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3104935B2 (en) | 1992-05-28 | 2000-10-30 | 株式会社ブリヂストン | Pneumatic tire |
| ATE505201T1 (en) * | 2002-02-14 | 2011-04-15 | Univ Leland Stanford Junior | ENZYME TREATMENT OF FOODS FOR CELIAIC SPRAY |
| US7320788B2 (en) * | 2002-02-14 | 2008-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
| US7265093B2 (en) * | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| US7468267B2 (en) | 2003-08-25 | 2008-12-23 | Funzyme Biotechnologies Sa | Fungal proteins and nucleic acids encoding same |
| ES2746173T3 (en) | 2003-09-23 | 2020-03-05 | Dsm Ip Assets Bv | Use of proline-specific endoproteases to hydrolyze peptides and proteins |
| NL1027650C1 (en) | 2004-12-03 | 2006-06-07 | Leonardus Antonius Luttikhold | Transport tool for doors and panels. |
| EP1985698A1 (en) * | 2007-04-25 | 2008-10-29 | Nestec S.A. | Peptidases from basidiomycetes |
| CA2784944A1 (en) * | 2009-12-21 | 2011-06-30 | Centre Hospitalier Universitaire Vaudois | Synergic action of a prolyl protease and tripeptidyl proteases |
| US9011842B2 (en) * | 2010-02-02 | 2015-04-21 | Amano Enzyme Inc. | Use of proteases for gluten intolerance |
| US20130045195A1 (en) * | 2010-03-30 | 2013-02-21 | Alvine Pharmaceuticals, Inc. | Proteases for Degrading Gluten |
| JP2011211997A (en) * | 2010-04-02 | 2011-10-27 | Astellas Pharma Inc | Microorganism producing anthracycline compound |
-
2012
- 2012-11-05 EP EP12781098.4A patent/EP2788018B1/en active Active
- 2012-11-05 CN CN201280060514.5A patent/CN104039345B/en active Active
- 2012-11-05 IN IN4131CHN2014 patent/IN2014CN04131A/en unknown
- 2012-11-05 US US14/356,122 patent/US20140356345A1/en not_active Abandoned
- 2012-11-05 EA EA201491117A patent/EA028228B1/en not_active IP Right Cessation
- 2012-11-05 AU AU2012348782A patent/AU2012348782B2/en active Active
- 2012-11-05 JP JP2014545146A patent/JP6203743B2/en active Active
- 2012-11-05 WO PCT/EP2012/071816 patent/WO2013083338A1/en active Application Filing
- 2012-11-05 BR BR112014012100-1A patent/BR112014012100B1/en active IP Right Grant
- 2012-11-05 CA CA2852365A patent/CA2852365C/en active Active
- 2012-11-05 ES ES12781098.4T patent/ES2595500T3/en active Active
-
2014
- 2014-11-21 HK HK14111801.0A patent/HK1198244A1/en unknown
-
2015
- 2015-11-23 US US14/949,503 patent/US10201593B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104039345A (en) | 2014-09-10 |
| WO2013083338A1 (en) | 2013-06-13 |
| US20160114009A1 (en) | 2016-04-28 |
| EA028228B1 (en) | 2017-10-31 |
| CA2852365C (en) | 2021-01-26 |
| AU2012348782A1 (en) | 2014-05-15 |
| JP2015500641A (en) | 2015-01-08 |
| US10201593B2 (en) | 2019-02-12 |
| CN104039345B (en) | 2016-11-09 |
| ES2595500T3 (en) | 2016-12-30 |
| AU2012348782B2 (en) | 2017-10-26 |
| EP2788018A1 (en) | 2014-10-15 |
| EP2788018B1 (en) | 2016-06-29 |
| JP6203743B2 (en) | 2017-09-27 |
| BR112014012100A2 (en) | 2020-10-27 |
| EA201491117A1 (en) | 2014-09-30 |
| HK1198244A1 (en) | 2015-03-20 |
| CA2852365A1 (en) | 2013-06-13 |
| BR112014012100B1 (en) | 2023-04-18 |
| US20140356345A1 (en) | 2014-12-04 |
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