IN2014CN04126A - - Google Patents
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- Publication number
- IN2014CN04126A IN2014CN04126A IN4126CHN2014A IN2014CN04126A IN 2014CN04126 A IN2014CN04126 A IN 2014CN04126A IN 4126CHN2014 A IN4126CHN2014 A IN 4126CHN2014A IN 2014CN04126 A IN2014CN04126 A IN 2014CN04126A
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- IN
- India
- Prior art keywords
- attachment
- group
- point
- compounds
- alkyl
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Detergent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
1a1b1a1b 1a" "1b213133534413The invention relates to antibacterial compounds of formula I (Fornula I) (I) wherein R represents H or carboxy and R represents H or R and R represent together either the group * C(0) NH S or the group * C(OH)=N S wherein "*" represents the point of attachment of R and represents the point of attachment of R; R represents H (C C)alkyl hydroxy (CC)alkyl benzyl or (C C)cycloalkyl; R represents H or halogen; U represents N or CR; wherein R is H or (C C)alkoxy; A represents CH B represents NH and m represents 1 or 2 and n represents 1 or 2; or A represents N B is absent m represents 2 and n represents 2; Y represents CH or N; and Q represents O or S; and salts of such compounds.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2011054968 | 2011-11-08 | ||
PCT/IB2012/056236 WO2013068948A1 (en) | 2011-11-08 | 2012-11-07 | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014CN04126A true IN2014CN04126A (en) | 2015-07-10 |
Family
ID=47258051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN4126CHN2014 IN2014CN04126A (en) | 2011-11-08 | 2012-11-07 |
Country Status (20)
Country | Link |
---|---|
US (1) | US9079922B2 (en) |
EP (1) | EP2776431B1 (en) |
JP (1) | JP6030146B2 (en) |
KR (1) | KR20140096337A (en) |
AR (1) | AR088691A1 (en) |
AU (1) | AU2012335207B2 (en) |
BR (1) | BR112014011064A8 (en) |
CA (1) | CA2854264A1 (en) |
CL (1) | CL2014001154A1 (en) |
ES (1) | ES2581056T3 (en) |
HK (1) | HK1202288A1 (en) |
IL (1) | IL232463A0 (en) |
IN (1) | IN2014CN04126A (en) |
MX (1) | MX344529B (en) |
PL (1) | PL2776431T3 (en) |
RU (1) | RU2616609C2 (en) |
SG (1) | SG11201401710PA (en) |
TW (1) | TWI594996B (en) |
WO (1) | WO2013068948A1 (en) |
ZA (1) | ZA201404176B (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2344495E (en) | 2008-10-07 | 2015-04-01 | Actelion Pharmaceuticals Ltd | Tricyclic oxazolidinone antibiotic compounds |
EA029361B1 (en) | 2013-04-16 | 2018-03-30 | Идорсиа Фармасьютиклз Лтд | Antibacterial biaromatic derivatives |
AR096135A1 (en) | 2013-05-02 | 2015-12-09 | Actelion Pharmaceuticals Ltd | DERIVATIVES OF QUINOLONA |
AR102256A1 (en) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | ANTIBACTERIAL BASIC BIAROMATIC DERIVATIVES WITH REPLACEMENT OF AMINOALCOXI |
MA41168A (en) | 2014-12-17 | 2017-10-24 | Acraf | NEW ANTIBACTERIAL COMPOUNDS |
MA41169A (en) | 2014-12-17 | 2017-10-24 | Acraf | WIDE-SPECTRUM ANTIBACTERIAL COMPOUNDS |
WO2017137743A1 (en) * | 2016-02-08 | 2017-08-17 | Redx Pharma Plc | Antibacterial compounds |
GB201602235D0 (en) * | 2016-02-08 | 2016-03-23 | Redx Pharma Plc | Antibacterial compounds |
BR112018016208A2 (en) * | 2016-02-08 | 2018-12-18 | Redx Pharma Plc | heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their uses as antibacterial compounds |
JP2019517545A (en) | 2016-06-08 | 2019-06-24 | アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニAziende Chimiche Riunite Angelini Francesco A.C.R.A.F.Societa Per Azioni | New antibacterial compounds |
TW201833120A (en) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | Aryloxazolidinone antibiotic compounds |
PT3634968T (en) | 2017-06-08 | 2023-04-14 | Bugworks Res Inc | Heterocyclic compounds useful as anti-bacterial agents and method for production thereof |
JP7390728B2 (en) | 2017-11-29 | 2023-12-04 | バグワークス・リサーチ・インコーポレイテッド | Antibacterial heterocyclic compounds and their synthesis |
Family Cites Families (26)
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US3149104A (en) | 1961-01-03 | 1964-09-15 | Sterling Drug Inc | 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters |
HU168497B (en) | 1972-12-18 | 1976-05-28 | ||
GB1598915A (en) | 1977-09-20 | 1981-09-23 | Bellon Labor Sa Roger | 1,4-dihydro-quinoline-3-carboxylic acid derivatives process for their preparation and composition containing them |
SE444566B (en) | 1977-09-20 | 1986-04-21 | Bellon Labor Sa Roger | 7-DIALKYLAMINE-6-HALOGEN-4-OXO-1,4-DIHYDROQINOLINE-3-CARBOXYLIC ACID, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATION OF THEREOF |
CS274601B2 (en) | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
JPS62205060A (en) | 1986-03-04 | 1987-09-09 | Kyorin Pharmaceut Co Ltd | 8-substituted quinolonecarboxylic acid derivative |
CN1019114B (en) | 1986-03-31 | 1992-11-18 | 三共株式会社 | Quinoline-3-carboxylic acid derivatives and the prepn. method thereof |
JP2631854B2 (en) | 1987-12-23 | 1997-07-16 | 藤本製薬株式会社 | Novel 1,8-naphthyridine derivative |
DE4301246A1 (en) | 1993-01-19 | 1994-07-21 | Bayer Ag | Quinolone and naphthyridonecarboxylic acid derivatives |
WO2004002973A1 (en) | 2002-06-28 | 2004-01-08 | Kaneka Corporation | Process for preparation of optically active 1-substituted amino-2,3-epoxypropanes, intermediates for the synthesis thereof and process for preparation of the intermediates |
CA2529347C (en) * | 2003-04-30 | 2011-09-06 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections |
WO2005058888A2 (en) * | 2003-12-18 | 2005-06-30 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
AU2005279050A1 (en) | 2004-07-30 | 2006-03-09 | Centre National De La Recherche Scientifique (Cnrs) | Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, and the synthesis and uses thereof as antibacterial agents |
US8613657B2 (en) | 2004-09-01 | 2013-12-24 | Christian Richard | System and method for permitting identification and counting of gaming chips |
US20090156577A1 (en) | 2004-09-09 | 2009-06-18 | Benjamin Davis | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
JP2009532504A (en) | 2006-04-06 | 2009-09-10 | グラクソ グループ リミテッド | Antibacterial drugs |
PT2086968E (en) * | 2006-11-10 | 2012-04-13 | Actelion Pharmaceuticals Ltd | 5-hydroxymethyl-oxazolidin-2-one derivatives |
CL2008001003A1 (en) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION. |
CL2008001002A1 (en) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION. |
MX2010006111A (en) * | 2007-12-18 | 2010-06-25 | Actelion Pharmaceuticals Ltd | 5-aminocyclylmethyl-oxazolidin-2-one derivatives. |
US8349826B2 (en) * | 2008-02-22 | 2013-01-08 | Actelion Pharmaceuticals Ltd. | Oxazolidinone derivatives |
PT2344495E (en) | 2008-10-07 | 2015-04-01 | Actelion Pharmaceuticals Ltd | Tricyclic oxazolidinone antibiotic compounds |
EP2346862B1 (en) * | 2008-10-10 | 2012-09-12 | Actelion Pharmaceuticals Ltd. | 2-benzothiophenyl-and 2-naphthyl-0xaz0lidin0nes and their azaisostere analogues as antibacterial agents |
BRPI0920870A2 (en) | 2008-10-10 | 2018-06-26 | Actelion Pharmaceuticals Ltd | oxazolidinyl antibiotics. |
TW201121965A (en) | 2009-09-28 | 2011-07-01 | Lg Life Sciences Ltd | Use of a quinolone derivative containing 7-(4-aminomethyl-3-oxime)pyrrolidine group that is capable of inducing granulocyte colony stimulating factor for treatment of neutropenia and recovery of hematopoiesis |
CN101792443A (en) | 2010-03-09 | 2010-08-04 | 北京欧凯纳斯科技有限公司 | Fluoro-carbostyril derivative as well as preparation method and application thereof |
-
2012
- 2012-11-07 KR KR1020147014957A patent/KR20140096337A/en active IP Right Grant
- 2012-11-07 ES ES12791863.9T patent/ES2581056T3/en active Active
- 2012-11-07 US US14/356,896 patent/US9079922B2/en not_active Expired - Fee Related
- 2012-11-07 EP EP12791863.9A patent/EP2776431B1/en not_active Not-in-force
- 2012-11-07 AU AU2012335207A patent/AU2012335207B2/en not_active Ceased
- 2012-11-07 TW TW101141423A patent/TWI594996B/en not_active IP Right Cessation
- 2012-11-07 RU RU2014123109A patent/RU2616609C2/en not_active IP Right Cessation
- 2012-11-07 BR BR112014011064A patent/BR112014011064A8/en not_active Application Discontinuation
- 2012-11-07 IN IN4126CHN2014 patent/IN2014CN04126A/en unknown
- 2012-11-07 AR ARP120104192A patent/AR088691A1/en unknown
- 2012-11-07 PL PL12791863.9T patent/PL2776431T3/en unknown
- 2012-11-07 MX MX2014005637A patent/MX344529B/en active IP Right Grant
- 2012-11-07 CA CA2854264A patent/CA2854264A1/en not_active Abandoned
- 2012-11-07 JP JP2014540612A patent/JP6030146B2/en not_active Expired - Fee Related
- 2012-11-07 SG SG11201401710PA patent/SG11201401710PA/en unknown
- 2012-11-07 WO PCT/IB2012/056236 patent/WO2013068948A1/en active Application Filing
-
2014
- 2014-04-30 CL CL2014001154A patent/CL2014001154A1/en unknown
- 2014-05-05 IL IL232463A patent/IL232463A0/en unknown
- 2014-06-06 ZA ZA2014/04176A patent/ZA201404176B/en unknown
-
2015
- 2015-03-16 HK HK15102622.5A patent/HK1202288A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2776431B1 (en) | 2016-05-04 |
AU2012335207A1 (en) | 2014-07-03 |
PL2776431T3 (en) | 2016-11-30 |
BR112014011064A8 (en) | 2017-12-26 |
US20150051188A1 (en) | 2015-02-19 |
CN103917539A (en) | 2014-07-09 |
AU2012335207B2 (en) | 2017-05-25 |
JP2014532754A (en) | 2014-12-08 |
KR20140096337A (en) | 2014-08-05 |
RU2616609C2 (en) | 2017-04-18 |
BR112014011064A2 (en) | 2017-06-13 |
TW201326166A (en) | 2013-07-01 |
CL2014001154A1 (en) | 2014-09-12 |
MX344529B (en) | 2016-12-19 |
MX2014005637A (en) | 2014-06-23 |
RU2014123109A (en) | 2015-12-20 |
ES2581056T3 (en) | 2016-08-31 |
IL232463A0 (en) | 2014-06-30 |
HK1202288A1 (en) | 2015-09-25 |
SG11201401710PA (en) | 2014-09-26 |
TWI594996B (en) | 2017-08-11 |
ZA201404176B (en) | 2016-05-25 |
US9079922B2 (en) | 2015-07-14 |
EP2776431A1 (en) | 2014-09-17 |
WO2013068948A1 (en) | 2013-05-16 |
CA2854264A1 (en) | 2013-05-16 |
JP6030146B2 (en) | 2016-11-24 |
AR088691A1 (en) | 2014-06-25 |
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