IN2014CN02346A - - Google Patents

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Publication number
IN2014CN02346A
IN2014CN02346A IN2346CHN2014A IN2014CN02346A IN 2014CN02346 A IN2014CN02346 A IN 2014CN02346A IN 2346CHN2014 A IN2346CHN2014 A IN 2346CHN2014A IN 2014CN02346 A IN2014CN02346 A IN 2014CN02346A
Authority
IN
India
Prior art keywords
carboxamide
imidazole
hydroxy
hydrate
acidic
Prior art date
Application number
Inventor
Taisuke Fujimoto
Tomohiro Hashimoto
Katsuyuki Hayashi
Tomoyuki Tanaka
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Publication of IN2014CN02346A publication Critical patent/IN2014CN02346A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

1 3A method for producing 5 hydroxy 1H imidazole 4 carboxamide 3/4 hydrate which comprises: a step wherein 2 amino malonamide is reacted with a compound represented by general formula (1) (wherein each R independently represents a C alkyl group) in the presence of a carboxylic acid so as to obtain 5 hydroxy 1H imidazole 4 carboxamide; a step wherein the thus obtained 5 hydroxy 1H imidazole 4 carboxamide is reacted with an acidic compound so as to obtain an acidic salt of 5 hydroxy 1H imidazole 4 carboxamide or a hydrate thereof; and a step wherein the thus obtained acidic salt of 5 hydroxy 1H imidazole 4 carboxamide or a hydrate thereof is reacted with a salt in the presence of an acidic solvent.
IN2346CHN2014 2011-09-28 2012-09-28 IN2014CN02346A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011213501 2011-09-28
JP2011213500 2011-09-28
PCT/JP2012/075106 WO2013047758A1 (en) 2011-09-28 2012-09-28 Crystal of 5-hydroxy-1h-imidazole-4-carboxamide hydrate, crystal of 5-hydroxy-1h-imidazole-4-carboxamide 3/4 hydrate, and method for producing same

Publications (1)

Publication Number Publication Date
IN2014CN02346A true IN2014CN02346A (en) 2015-06-19

Family

ID=47995783

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2346CHN2014 IN2014CN02346A (en) 2011-09-28 2012-09-28

Country Status (14)

Country Link
US (2) US9108928B2 (en)
EP (1) EP2762469B1 (en)
KR (1) KR101970509B1 (en)
CN (1) CN103827093B (en)
AU (1) AU2012317424B2 (en)
BR (1) BR112014007436A2 (en)
CA (1) CA2850196A1 (en)
HK (1) HK1197406A1 (en)
IL (2) IL231677A (en)
IN (1) IN2014CN02346A (en)
MX (1) MX354498B (en)
RU (2) RU2630682C2 (en)
SG (1) SG11201400974VA (en)
WO (1) WO2013047758A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2850196A1 (en) 2011-09-28 2013-04-04 Fujifilm Corporation Crystal of 5-hydroxy-1h-imidazole-4-carboxamide-3/4 hydrate, method for producing the same and crystal of 5-hydroxy-1h-imidazole-4-carboxamide hydrate
JP6001684B2 (en) * 2013-01-15 2016-10-05 富士フイルム株式会社 5-hydroxy-1H-imidazole-4-carboxamide sulfate
CA2935905C (en) 2014-01-10 2019-02-05 Fujifilm Corporation Method and apparatus for predicting effective dose or sensitivity of 5-hydroxy-1h-imidazole-4-carboxamide, method for determining amount of xanthosine monophosphate, and treatmentagent and method for treating myelodysplastic syndrome
WO2018051971A1 (en) * 2016-09-13 2018-03-22 富士フイルム株式会社 Drug, method, use and compound for preventing or treating mll-related leukemia
JP6896093B2 (en) * 2017-10-27 2021-06-30 富士フイルム株式会社 Method for Producing 5-Hydroxy-1H-Imidazole-4-Carboxamide 3/4 Hydrate

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181731A (en) * 1976-09-07 1980-01-01 Sumitomo Chemical Company, Limited Novel therapeutic application of 4-carbamoyl-5-hydroxyimidazole
JPS5625165A (en) * 1979-08-08 1981-03-10 Sumitomo Chem Co Ltd Novel imidazole derivative
JPS5824569A (en) 1981-08-05 1983-02-14 Sumitomo Chem Co Ltd Purification of imidazole derivative
US4503235A (en) 1983-03-11 1985-03-05 Warner-Lambert Company Process for producing 4-carbamoyl-1H-imidazolium-5-olate
JPS60185727A (en) 1984-03-05 1985-09-21 Sumitomo Chem Co Ltd Stabilization of 4-carbamoylimidazolium-5-oleate preparation
CA2152863A1 (en) 1994-07-26 1996-01-27 Yeun-Kwei Han Preparation of acyclovir
US5567816A (en) 1994-07-26 1996-10-22 Syntex (U.S.A.) Inc. Preparation of acyclovir using 1,3 dioxolane
US7002023B2 (en) 2000-09-29 2006-02-21 Basf Aktiengesellschaft Method for producing 1 substituted 5-chloro-4 methly pyrazoles
JP2002265601A (en) 2001-03-07 2002-09-18 Rikogaku Shinkokai Imide resin
EP1874734A1 (en) * 2005-02-16 2008-01-09 Solvay Pharmaceuticals B.V. 1h-imidiazole derivatives as cannabinoid cb2 receptor modulators
CN101395141A (en) * 2006-02-24 2009-03-25 莱西肯医药有限公司 Imidazole-based compounds, compositions comprising them and methods of their use
JP5266010B2 (en) 2007-09-14 2013-08-21 富士フイルム株式会社 4-Carbamoyl-5-hydroxy-imidazole derivative sulfonate compound
KR100982720B1 (en) * 2008-02-04 2010-09-17 주식회사 파마코스텍 Manufacturing Process of 2-Aminomalonamide as Intermediate for Producing 4-Carbamoyl-1-?-D-ribofuranosylimidazolium-5-olate
TWI573791B (en) 2011-09-28 2017-03-11 富士軟片股份有限公司 Method for producing 5-hydroxy-1h-imidazole-4-carboxamide.3/4 hydrate and crystals thereof
CA2850196A1 (en) 2011-09-28 2013-04-04 Fujifilm Corporation Crystal of 5-hydroxy-1h-imidazole-4-carboxamide-3/4 hydrate, method for producing the same and crystal of 5-hydroxy-1h-imidazole-4-carboxamide hydrate

Also Published As

Publication number Publication date
RU2014111810A (en) 2015-11-10
CA2850196A1 (en) 2013-04-04
EP2762469B1 (en) 2016-11-23
CN103827093B (en) 2016-06-15
AU2012317424A1 (en) 2014-04-17
EP2762469A4 (en) 2015-01-14
AU2012317424A8 (en) 2014-07-03
RU2630682C2 (en) 2017-09-12
RU2672560C1 (en) 2018-11-16
MX2014003638A (en) 2014-05-21
CN103827093A (en) 2014-05-28
IL246754A (en) 2017-08-31
KR20140069052A (en) 2014-06-09
KR101970509B1 (en) 2019-04-19
NZ622928A (en) 2015-04-24
US20150315156A1 (en) 2015-11-05
BR112014007436A2 (en) 2017-04-04
MX354498B (en) 2018-03-08
HK1197406A1 (en) 2015-01-16
US9567303B2 (en) 2017-02-14
IL231677A (en) 2017-01-31
EP2762469A1 (en) 2014-08-06
SG11201400974VA (en) 2014-09-26
US20140275568A1 (en) 2014-09-18
AU2012317424B2 (en) 2017-05-18
WO2013047758A1 (en) 2013-04-04
US9108928B2 (en) 2015-08-18
IL231677A0 (en) 2014-05-28

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