IN2013CH05537A - - Google Patents

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Publication number
IN2013CH05537A
IN2013CH05537A IN5537CH2013A IN2013CH05537A IN 2013CH05537 A IN2013CH05537 A IN 2013CH05537A IN 5537CH2013 A IN5537CH2013 A IN 5537CH2013A IN 2013CH05537 A IN2013CH05537 A IN 2013CH05537A
Authority
IN
India
Prior art keywords
methyl
cognition
schizophrenia
bromophenyl
piperazinyl
Prior art date
Application number
Inventor
Ramakrishna Nirogi
Rama Sastri Kambhampati
Anil Karbhari Shinde
Venkateswarlu Jasti
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2929309A priority Critical patent/CA2929309C/en
Priority to AP2016009224A priority patent/AP2016009224A0/en
Priority to BR112016010788-8A priority patent/BR112016010788B1/en
Priority to CN201480065601.9A priority patent/CN105814020B/en
Priority to RS20170853A priority patent/RS56323B1/en
Priority to EA201691161A priority patent/EA028038B1/en
Priority to LTEP14725245.6T priority patent/LT3077375T/en
Priority to PL14725245T priority patent/PL3077375T3/en
Priority to NZ719671A priority patent/NZ719671A/en
Priority to MX2016006629A priority patent/MX364930B/en
Priority to US15/100,489 priority patent/US9540321B2/en
Priority to ES14725245.6T priority patent/ES2638856T3/en
Priority to DK14725245.6T priority patent/DK3077375T3/en
Priority to HUE14725245A priority patent/HUE036008T2/en
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Priority to IN5537CH2013 priority patent/IN2013CH05537A/en
Priority to PCT/IN2014/000109 priority patent/WO2015083179A1/en
Priority to KR1020167013965A priority patent/KR101808792B1/en
Priority to SI201430348T priority patent/SI3077375T1/en
Priority to PT147252456T priority patent/PT3077375T/en
Priority to JP2016535680A priority patent/JP6151453B2/en
Priority to AU2014358682A priority patent/AU2014358682B2/en
Priority to MEP-2017-193A priority patent/ME02843B/en
Priority to EP14725245.6A priority patent/EP3077375B1/en
Publication of IN2013CH05537A publication Critical patent/IN2013CH05537A/en
Priority to ZA2016/02954A priority patent/ZA201602954B/en
Priority to IL245619A priority patent/IL245619B/en
Priority to HK16114655A priority patent/HK1226396B/en
Priority to HRP20171245TT priority patent/HRP20171245T1/en
Priority to CY20171100904T priority patent/CY1119298T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

A process suitable for adoption to large scale manufacture of l-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-l-piperazinyl)methyl]-lH-indole dimesylate monohydrate, which is a selective 5-HT6 receptor antagonist intended for the symptomatic treatment of Alzheimer's disease and other disorders of memory and cognition like Attention deficient hyperactivity, Parkinson's and Schizophrenia.
IN5537CH2013 2013-12-02 2014-02-20 IN2013CH05537A (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
IN5537CH2013 IN2013CH05537A (en) 2013-12-02 2014-02-20
AP2016009224A AP2016009224A0 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
CN201480065601.9A CN105814020B (en) 2013-12-02 2014-02-20 Method for mass producing 1 [(2 bromophenyl) sulfonyl] 5 methoxyl group 3 [(4 methyl, 1 piperazinyl) methyl] 1H indoles dimethanesulfonate monohydrates
RS20170853A RS56323B1 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
EA201691161A EA028038B1 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
LTEP14725245.6T LT3077375T (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
PL14725245T PL3077375T3 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
NZ719671A NZ719671A (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
MX2016006629A MX364930B (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl] -5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate.
US15/100,489 US9540321B2 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate
ES14725245.6T ES2638856T3 (en) 2013-12-02 2014-02-20 Process for large-scale production of 1 - [(2-bromophenyl) sulfonyl] -5-methoxy-3 - [(4-methyl-1-piperazinyl) methyl] -1H-indole monohydrate dimesylate
DK14725245.6T DK3077375T3 (en) 2013-12-02 2014-02-20 PROCEDURE FOR LARGE SCALE PREPARATION OF 1 - [(2-BROMPHENYL) SULPHONYL] -5-METHOXY-3 - [(4-METHYL-1-PIPERAZINYL) METHYL] -1H-INDOL-DIMESYLATE-MONOHYDRATE
HUE14725245A HUE036008T2 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
CA2929309A CA2929309C (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
BR112016010788-8A BR112016010788B1 (en) 2013-12-02 2014-02-20 PROCESS FOR THE LARGE-SCALE PRODUCTION OF 1-[(2-BROMOPHENYL)SULFONYL]-5-METHOXY-3-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-INDOLE
PCT/IN2014/000109 WO2015083179A1 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
KR1020167013965A KR101808792B1 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
SI201430348T SI3077375T1 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-((2-bromophenyl)sulfonyl)-5-methoxy-3-((4-methyl-1-piperazinyl)methyl)-1h-indole dimesylate monohydrate
PT147252456T PT3077375T (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
JP2016535680A JP6151453B2 (en) 2013-12-02 2014-02-20 Large-scale synthesis of 1-[(2-bromophenyl) sulfonyl] -5-methoxy-3-[(4-methyl-1-piperazinyl) methyl] -1H-indole dimesylate monohydrate
AU2014358682A AU2014358682B2 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate
MEP-2017-193A ME02843B (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
EP14725245.6A EP3077375B1 (en) 2013-12-02 2014-02-20 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
ZA2016/02954A ZA201602954B (en) 2013-12-02 2016-05-03 Process for large scale production of 1-{(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
IL245619A IL245619B (en) 2013-12-02 2016-05-11 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
HK16114655A HK1226396B (en) 2013-12-02 2016-12-23 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
HRP20171245TT HRP20171245T1 (en) 2013-12-02 2017-08-16 Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
CY20171100904T CY1119298T1 (en) 2013-12-02 2017-08-28 PROCEDURE FOR PRODUCING LARGE-SCALE OF 1- (2-BROMOPHENYL) SULFONYL] -5-METHOXY-3 - [(4-METHYL-1-PIPERAZINYL) METHYL] -1H-1 NIDOLEYM MON

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN5537CH2013 IN2013CH05537A (en) 2013-12-02 2014-02-20

Publications (1)

Publication Number Publication Date
IN2013CH05537A true IN2013CH05537A (en) 2015-06-12

Family

ID=54199404

Family Applications (1)

Application Number Title Priority Date Filing Date
IN5537CH2013 IN2013CH05537A (en) 2013-12-02 2014-02-20

Country Status (28)

Country Link
US (1) US9540321B2 (en)
EP (1) EP3077375B1 (en)
JP (1) JP6151453B2 (en)
KR (1) KR101808792B1 (en)
CN (1) CN105814020B (en)
AP (1) AP2016009224A0 (en)
AU (1) AU2014358682B2 (en)
BR (1) BR112016010788B1 (en)
CA (1) CA2929309C (en)
CY (1) CY1119298T1 (en)
DK (1) DK3077375T3 (en)
EA (1) EA028038B1 (en)
ES (1) ES2638856T3 (en)
HK (1) HK1226396B (en)
HR (1) HRP20171245T1 (en)
HU (1) HUE036008T2 (en)
IL (1) IL245619B (en)
IN (1) IN2013CH05537A (en)
LT (1) LT3077375T (en)
ME (1) ME02843B (en)
MX (1) MX364930B (en)
NZ (1) NZ719671A (en)
PL (1) PL3077375T3 (en)
PT (1) PT3077375T (en)
RS (1) RS56323B1 (en)
SI (1) SI3077375T1 (en)
WO (1) WO2015083179A1 (en)
ZA (1) ZA201602954B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA45002B1 (en) * 2016-05-18 2020-10-28 Suven Life Sciences Ltd Triple combination of pure 5-ht6 receptor antagonists, acetylcholinesterase inhibitors and nmda receptor antagonists
KR102023748B1 (en) * 2016-05-18 2019-09-20 수벤 라이프 사이언시스 리미티드 Combination of pure 5-HT6 receptor antagonists and NMDA receptor antagonists
RS60422B1 (en) * 2016-05-18 2020-07-31 Suven Life Sciences Ltd Combination of pure 5-ht6 receptor antagonists with acetylcholinesterase inhibitors
US20210346374A1 (en) * 2016-10-03 2021-11-11 Suven Life Sciences Limited Pharmaceutical compositions of 5-ht6 receptor antagonist
EA036235B1 (en) 2016-10-03 2020-10-16 Сувен Лайф Сайенсиз Лимитед Pharmaceutical compositions of 5-ht6 antagonist
EP3648765A1 (en) * 2017-07-03 2020-05-13 Suven Life Sciences Limited New uses of a pure 5-ht 6 receptor antagonist
AU2020396396A1 (en) 2019-12-02 2022-06-16 Suven Life Sciences Limited Methods for treating behavioral and psychological symptoms in patients with dementia
CA3162952A1 (en) 2019-12-02 2021-06-10 Suven Life Sciences Limited Treating behavioral and psychological symptoms in dementia patients
CN111362859B (en) * 2020-03-16 2021-05-11 东莞市东阳光新药研发有限公司 Salts of heteroaromatic derivatives and use thereof
CN111233737B (en) * 2020-03-16 2021-05-11 东莞市东阳光新药研发有限公司 Salts of heteroaromatic derivatives and use thereof
CN111362858B (en) * 2020-03-16 2021-05-11 东莞市东阳光新药研发有限公司 Salts of heteroaromatic derivatives and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2749846B1 (en) * 1996-06-17 1998-09-11 Pf Medicament METHANESULFONATE SALT OF ARYLPIPERAZINE DERIVED FROM TRYPTAMINE AND ITS SOLVATES FOR PHARMACEUTICAL USE
KR100818508B1 (en) 2002-11-28 2008-03-31 수벤 라이프 사이언시스 리미티드 N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
KR100739987B1 (en) * 2002-12-18 2007-07-16 수벤 라이프 사이언시스 리미티드 Tetracyclic 3-substituted indoles having serotonin receptor affinity
JP2009540007A (en) * 2006-06-12 2009-11-19 ノバルティス アクチエンゲゼルシャフト Process for producing a salt of N-hydroxy-3- [4-[[[2- (2-methyl-1H-indol-3-yl) ethyl] amino] methyl] phenyl] -2E-2-propenamide

Also Published As

Publication number Publication date
BR112016010788B1 (en) 2023-03-21
MX2016006629A (en) 2016-08-08
ES2638856T3 (en) 2017-10-24
HK1226396B (en) 2017-09-29
HUE036008T2 (en) 2018-06-28
HRP20171245T1 (en) 2017-10-20
JP2016539133A (en) 2016-12-15
NZ719671A (en) 2017-03-31
SI3077375T1 (en) 2017-10-30
EA201691161A1 (en) 2016-09-30
IL245619B (en) 2018-12-31
CY1119298T1 (en) 2018-02-14
KR101808792B1 (en) 2017-12-13
CA2929309C (en) 2018-07-03
WO2015083179A1 (en) 2015-06-11
BR112016010788A8 (en) 2018-01-30
PT3077375T (en) 2017-09-05
US20160297759A1 (en) 2016-10-13
AU2014358682B2 (en) 2016-10-20
EP3077375B1 (en) 2017-07-19
EA028038B1 (en) 2017-09-29
AP2016009224A0 (en) 2016-05-31
AU2014358682A1 (en) 2016-06-02
MX364930B (en) 2019-05-14
ME02843B (en) 2018-01-20
KR20160094945A (en) 2016-08-10
RS56323B1 (en) 2017-12-29
JP6151453B2 (en) 2017-06-21
IL245619A0 (en) 2016-06-30
EP3077375A1 (en) 2016-10-12
LT3077375T (en) 2017-09-11
CN105814020B (en) 2018-04-17
US9540321B2 (en) 2017-01-10
ZA201602954B (en) 2017-07-26
CA2929309A1 (en) 2015-06-11
DK3077375T3 (en) 2017-09-11
PL3077375T3 (en) 2017-11-30
CN105814020A (en) 2016-07-27

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