IN2013CH04511A - - Google Patents

Info

Publication number
IN2013CH04511A
IN2013CH04511A IN4511CH2013A IN2013CH04511A IN 2013CH04511 A IN2013CH04511 A IN 2013CH04511A IN 4511CH2013 A IN4511CH2013 A IN 4511CH2013A IN 2013CH04511 A IN2013CH04511 A IN 2013CH04511A
Authority
IN
India
Prior art keywords
preparation
present
provides
ragorafenib
crystalline solid
Prior art date
Application number
Inventor
Reddy Bandi Parthasaradhi
Reddy Kura Rathnakar
Reddy Dasari Muralidhara
Rao Thungathurthy Srinivasa
Krishna Bandi Vamsi
Original Assignee
Hetero Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hetero Research Foundation filed Critical Hetero Research Foundation
Priority to US15/026,694 priority Critical patent/US9518020B2/en
Priority to PCT/IN2014/000630 priority patent/WO2015049698A2/en
Priority to IN4511CH2013 priority patent/IN2013CH04511A/en
Publication of IN2013CH04511A publication Critical patent/IN2013CH04511A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

The present invention provides a crystalline solid of 4-(4-amino-3-fluorophenoxy)-N-methylpicolinamide and process for its preparation. The present invention also provides a crystalline solid of ragorafenib tosylate and process for its preparation. The present invention further provides a novel process for the preparation of ragorafenib Polymorph I.
IN4511CH2013 2013-10-04 2014-09-29 IN2013CH04511A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US15/026,694 US9518020B2 (en) 2013-10-04 2014-09-29 Process for Regorafenib
PCT/IN2014/000630 WO2015049698A2 (en) 2013-10-04 2014-09-29 Process for regorafenib
IN4511CH2013 IN2013CH04511A (en) 2013-10-04 2014-09-29

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN4511CH2013 IN2013CH04511A (en) 2013-10-04 2014-09-29

Publications (1)

Publication Number Publication Date
IN2013CH04511A true IN2013CH04511A (en) 2015-04-10

Family

ID=52779244

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4511CH2013 IN2013CH04511A (en) 2013-10-04 2014-09-29

Country Status (3)

Country Link
US (1) US9518020B2 (en)
IN (1) IN2013CH04511A (en)
WO (1) WO2015049698A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105330600B (en) * 2015-11-30 2018-05-22 山东罗欣药业集团股份有限公司 A kind of preparation method of Rui Gefeini
WO2017125941A1 (en) * 2016-01-18 2017-07-27 Natco Pharma Ltd An improved process for the preparation of regorafenib
CN108440403A (en) * 2018-03-31 2018-08-24 山东罗欣药业集团恒欣药业有限公司 A kind of preparation method of Rui Gefeini
CN108558747A (en) * 2018-03-31 2018-09-21 山东罗欣药业集团恒欣药业有限公司 A kind of preparation method of Rui Gefeini

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY191349A (en) * 2004-08-27 2022-06-17 Bayer Pharmaceuticals Corp New pharmaceutical compositions for the treatment of hyper-proliferative disorders
AR062927A1 (en) * 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4- ([[4- CHLORINE-3- (TRIFLUOROMETILE) PHENYL) CARBAMOIL] AMINO] -3- FLUOROPHENOXY) -N- METHYLPIRIDIN-2-MONOHIDRATED CARBOXAMIDE
US20120225057A1 (en) * 2006-10-11 2012-09-06 Deciphera Pharmaceuticals, Llc Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases
WO2011080749A1 (en) 2009-12-29 2011-07-07 Hetero Research Foundation Process for purification of ziprasidone
AR081060A1 (en) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag PROCEDURE TO PREPARE 4- {4 - [({[4-CHLORINE-3- (TRIFLUOROMETIL) PHENYL] AMINO} CARBONYL) AMINO] -3-FLUOROPHENOXY} -N-METHYLPIRIDIN-2-CARBOXAMIDE

Also Published As

Publication number Publication date
US9518020B2 (en) 2016-12-13
US20160251313A1 (en) 2016-09-01
WO2015049698A3 (en) 2015-08-13
WO2015049698A2 (en) 2015-04-09

Similar Documents

Publication Publication Date Title
NZ765780A (en) 2-(morpholin-4-yl)-1,7-naphthyridines
HRP20181698T1 (en) 2-amino-6-(difluoromethyl)- 5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as bace1 inhibitors
NZ726859A (en) Synthesis of polycyclic-carbamoylpyridone compounds
PH12017500833A1 (en) Synthesis of copanlisib and its dihydrochloride salt
IN2013MU00646A (en)
MY183123A (en) Synthesis of copanlisib and its di hydrochloride salt
IN2013MU00848A (en)
GB201311938D0 (en) Process for preparing clomazone, a novel form and use of the same
IN2014MU00675A (en)
IN2013CH04511A (en)
IN2013MU01113A (en)
IL239987A (en) Process for producing pyridazinone compound and production intermediates thereof
PL3154967T3 (en) Processes for making alkylated arylpiperazine and alkylated arylpiperidine compounds including novel intermediates
PT2799426T (en) New process for the synthesis of aminaphtone
PT3368513T (en) Process for the synthesis of pirfenidone
MX2017012960A (en) Method for producing acylsulfamoylbenzamides.
MX2015011881A (en) Process for the preparation of 3,7-dimethylnonan-1-ol.
MX2016002198A (en) Process for preparing a compound.
IL265893A (en) Crystalline forms of 4-(2-((1r,2r)-2-hydroxycyclohexylamino) benzothiazol-6-yloxy)-n-methylpicolinamide
IN2014CH00444A (en)
NZ702523A (en) Production of n-substituted sulfoximine pyridine n-oxides
WO2014170909A3 (en) Process for pomalidomide
IN2013MU01524A (en)
MX2018001296A (en) Process for the synthesis of ravidasvir.
MX2016001100A (en) Improved process for the preparation of crystalline form iv of posaconazole.