IN2012DN00640A - - Google Patents

Download PDF

Info

Publication number
IN2012DN00640A
IN2012DN00640A IN640DEN2012A IN2012DN00640A IN 2012DN00640 A IN2012DN00640 A IN 2012DN00640A IN 640DEN2012 A IN640DEN2012 A IN 640DEN2012A IN 2012DN00640 A IN2012DN00640 A IN 2012DN00640A
Authority
IN
India
Prior art keywords
variable domains
hosts
ligands
vectors
compositions
Prior art date
Application number
Inventor
Coulstock Edward
De Angelis Elena
Liu Haiqun
Schon Oliver
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IN2012DN00640A publication Critical patent/IN2012DN00640A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to improved anti-serum albumin immunoglobulin single variable domains, as well as ligands and drug conjugates comprising such variable domains, compositions, nucleic acids, vectors and hosts.
IN640DEN2012 2009-07-16 2010-07-14 IN2012DN00640A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22602809P 2009-07-16 2009-07-16
US30755410P 2010-02-24 2010-02-24
PCT/EP2010/060112 WO2011006915A2 (en) 2009-07-16 2010-07-14 Improved anti-serum albumin binding single variable domains

Publications (1)

Publication Number Publication Date
IN2012DN00640A true IN2012DN00640A (en) 2015-08-21

Family

ID=42829253

Family Applications (1)

Application Number Title Priority Date Filing Date
IN640DEN2012 IN2012DN00640A (en) 2009-07-16 2010-07-14

Country Status (15)

Country Link
US (2) US8679496B2 (en)
EP (1) EP2454285A2 (en)
JP (1) JP2012532620A (en)
KR (1) KR20120038494A (en)
CN (1) CN102574914A (en)
AU (1) AU2010272590B2 (en)
BR (1) BR112012001681A2 (en)
CA (1) CA2768462A1 (en)
EA (1) EA201270174A1 (en)
IL (1) IL217520A0 (en)
IN (1) IN2012DN00640A (en)
MX (1) MX2012000765A (en)
SG (1) SG177601A1 (en)
WO (1) WO2011006915A2 (en)
ZA (1) ZA201200276B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2398827A2 (en) * 2009-02-19 2011-12-28 Glaxo Group Limited Improved anti-tnfr1 polypeptides, antibody variable domains&antagonists
IN2012DN00640A (en) * 2009-07-16 2015-08-21 Glaxo Group Ltd
US9012609B2 (en) 2010-08-13 2015-04-21 Glaxosmithkline Intellectual Property Development Limited Anti-serum albumin binding variants
US20130266567A1 (en) * 2010-12-01 2013-10-10 Haren Arulanantham Anti-serum albumin binding single variable domains
PT2776466T (en) 2011-11-11 2017-11-30 Ucb Biopharma Sprl Albumin binding antibodies and binding fragments thereof
GB201200563D0 (en) * 2012-01-13 2012-02-29 Imp Innovations Ltd Binding molecule
WO2017041114A2 (en) * 2015-09-03 2017-03-09 The Children's Mercy Hospital Anti-nicotinamide phosphoribosyltransferase antibody genes and methods of use thereof
NO2768984T3 (en) 2015-11-12 2018-06-09
JP7195142B2 (en) * 2015-11-13 2022-12-23 アブリンクス エン．ヴェー． Improved serum albumin-binding immunoglobulin variable domains
MY189018A (en) 2015-11-18 2022-01-19 Merck Sharp & Dohme Pd1 and/or lag3 binders
AU2016355568A1 (en) 2015-11-18 2018-06-21 Merck Sharp & Dohme Llc PD1/CTLA4 Binders
US10501542B2 (en) 2015-11-18 2019-12-10 Merck Sharp & Dohme Corp. CTLA4 binders
US11332519B2 (en) 2015-11-18 2022-05-17 Ablynx N.V. Serum albumin binders
JP7417421B2 (en) 2016-12-07 2024-01-18 アブリンクス エン．ヴェー． Improved serum albumin-binding immunoglobulin single variable domain
MX2019008496A (en) 2017-01-17 2019-09-18 Ablynx Nv Improved serum albumin binders.
KR20230165374A (en) 2017-01-17 2023-12-05 아블린쓰 엔.브이. Improved serum albumin binders
NZ756674A (en) 2017-02-16 2023-06-30 Sonnet Biotherapeutics Inc Albumin binding domain fusion proteins
EP3470426A1 (en) 2017-10-10 2019-04-17 Numab Therapeutics AG Multispecific antibody
SG11202002982YA (en) 2017-10-10 2020-04-29 Numab Therapeutics AG Multispecific antibody
EP3927740A4 (en) * 2019-02-22 2023-03-01 Anwita Biosciences, Inc. Albumin binding antibodies and use thereof
EP3816185A1 (en) 2019-11-04 2021-05-05 Numab Therapeutics AG Multispecific antibody directed against pd-l1 and a tumor-associated antigen
GB201919061D0 (en) 2019-12-20 2020-02-05 Ucb Biopharma Sprl Multi-specific antibody
WO2021205183A1 (en) 2020-04-09 2021-10-14 Autolus Limited Polypeptide
GB202007441D0 (en) 2020-05-19 2020-07-01 Autolus Ltd Polypeptide
EP3915580A1 (en) 2020-05-29 2021-12-01 Numab Therapeutics AG Multispecific antibody
EP3988568A1 (en) 2020-10-21 2022-04-27 Numab Therapeutics AG Combination treatment
EP4255926A1 (en) 2020-12-07 2023-10-11 UCB Biopharma SRL Multi-specific antibodies and antibody combinations
KR20230166075A (en) 2021-02-02 2023-12-06 누맙 세러퓨틱스 아게 Multispecific antibodies with specificity for ROR1 and CD3
EP4183800A1 (en) 2021-11-19 2023-05-24 Medizinische Hochschule Hannover Novel sars-cov-2 neutralizing antibodies
WO2024038095A1 (en) 2022-08-16 2024-02-22 Iome Bio NOVEL ANTI-RGMb ANTIBODIES

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
CA2450793A1 (en) * 2001-06-20 2002-12-27 Prochon Biotech Ltd. Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
US20100081792A1 (en) * 2001-06-28 2010-04-01 Smithkline Beecham Corporation Ligand
CN1678634A (en) 2002-06-28 2005-10-05 多曼蒂斯有限公司 Immunoglobulin single variable antigen combination area and its opposite constituent
US9321832B2 (en) * 2002-06-28 2016-04-26 Domantis Limited Ligand
ES2351509T3 (en) 2004-03-24 2011-02-07 Domantis Limited UNIVERSAL LEADING SEQUENCE OF GAS1.
EP2740743A3 (en) 2004-06-01 2015-08-19 Domantis Limited Bispecific fusion antibodies with enhanced serum half-life
US7563443B2 (en) * 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
GB0521621D0 (en) * 2005-10-24 2005-11-30 Domantis Ltd Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases
JP5185624B2 (en) 2004-12-02 2013-04-17 ドマンティス リミテッド Bispecific antibodies targeting serum albumin and GLP-1 or PYY
BRPI0619225A2 (en) * 2005-12-01 2017-11-07 Domantis Ltd domain antibody monomer, ligand, isolated and recombinant nucleic acids, vector, host cell, method for producing a ligand dab monomer, pharmaceutical composition, drug delivery device, use of a domain antibody monomer, and, method to treat an inflammatory disease, arthritis or respiratory disease
CA2629850A1 (en) * 2005-12-01 2007-06-07 Domantis Limited Competitive domain antibody formats that bind interleukin 1 receptor type 1
TW200804425A (en) * 2005-12-06 2008-01-16 Domantis Ltd Ligands that have binding specificity for EGFR and/or VEGF and methods of use therefor
US20100047171A1 (en) 2006-01-24 2010-02-25 Roland Beckmann Fusion Proteins That Contain Natural Junctions
CA2636854A1 (en) * 2006-01-24 2007-08-02 Domantis Limited Ligands that bind il-4 and/or il-13
CA2688434A1 (en) 2007-06-06 2008-12-11 Domantis Limited Polypeptides, antibody variable domains and antagonists
WO2009149143A1 (en) * 2008-06-03 2009-12-10 E. I. Du Pont De Nemours And Company Adhesion of polyamides to epoxy resins
US8906035B2 (en) * 2008-06-04 2014-12-09 Ethicon Endo-Surgery, Inc. Endoscopic drop off bag
EP2647701A3 (en) * 2008-06-06 2013-12-25 The Procter and Gamble Company Compositions and methods comprising variant microbial proteases
US10198891B2 (en) * 2008-06-06 2019-02-05 Epona Llc System and method for regulating fuel transactions
IN2012DN00640A (en) * 2009-07-16 2015-08-21 Glaxo Group Ltd

Also Published As

Publication number Publication date
US20120114647A1 (en) 2012-05-10
BR112012001681A2 (en) 2019-09-24
AU2010272590B2 (en) 2013-10-10
SG177601A1 (en) 2012-02-28
CA2768462A1 (en) 2011-01-20
EP2454285A2 (en) 2012-05-23
CN102574914A (en) 2012-07-11
IL217520A0 (en) 2012-02-29
EA201270174A1 (en) 2012-07-30
US8679496B2 (en) 2014-03-25
WO2011006915A2 (en) 2011-01-20
JP2012532620A (en) 2012-12-20
ZA201200276B (en) 2012-09-26
AU2010272590A1 (en) 2012-02-02
KR20120038494A (en) 2012-04-23
US20140140996A1 (en) 2014-05-22
WO2011006915A3 (en) 2011-03-03
MX2012000765A (en) 2012-02-13

Similar Documents

Publication Publication Date Title
IN2012DN00640A (en)
MX2011008752A (en) Improved anti-serum albumin binding variants.
MX2012013406A (en) Improved anti-serum albumin binding variants.
MX2011008749A (en) Improved anti-serum albumin binding variants.
CY1119567T1 (en) Therapeutic Peptides
WO2014083208A9 (en) Binding proteins comprising at least two repeat domains against her2
MX2012003939A (en) Drug fusions and conjugates with extended half life.
MX2015011075A (en) Therapeutic peptides.
WO2013072813A3 (en) Cytotoxic peptides and antibody drug conjugates thereof
WO2013130683A3 (en) Xten conjugate compositions and methods of making same
UA110370C2 (en) Conjugates of amatoxin with improved linkages
WO2011123820A3 (en) Single isomeric conjugates of rhodamine dyes
WO2011086143A3 (en) Liver targeting domain antibodies
UA106900C2 (en) LibreOfficeDR5-BINDING POLYPEPTIDE
WO2012072731A3 (en) Improved anti-serum albumin binding single variable domains
WO2011112566A3 (en) Basigin binding proteins
MX2013002055A (en) Improved anti-serum albumin binding variants.
CA3036643C (en) Cmet monoclonal binding agents, drug conjugates thereof and uses thereof
MX2015014198A (en) Antibodies targeting m-csf.
WO2014044793A3 (en) Cd22-binding peptides
EP2569327A4 (en) Eif4e binding peptides
MX2016008478A (en) Novel anti adam17 antibody and its use for the treatment of cancer.
WO2008005470A3 (en) Polypeptides that bind membrane proteins
WO2016005474A8 (en) Site selective conjugation of an oligonucleotide conjugate or a small molecule to a metal binding protein
CR20110473A (en) VARIATIONS OF UNION TO ANTI-ALBÚMINA DE SERERO IMPROVED.