IL94963A0 - Use of polyamines as ionic-channel regulating agents - Google Patents

Use of polyamines as ionic-channel regulating agents

Info

Publication number
IL94963A0
IL94963A0 IL9094963A IL9496390A IL94963A0 IL 94963 A0 IL94963 A0 IL 94963A0 IL 9094963 A IL9094963 A IL 9094963A IL 9496390 A IL9496390 A IL 9496390A IL 94963 A0 IL94963 A0 IL 94963A0
Authority
IL
Israel
Prior art keywords
polyamines
ionic
regulating agents
channel regulating
channel
Prior art date
Application number
IL9094963A
Original Assignee
Univ New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York filed Critical Univ New York
Publication of IL94963A0 publication Critical patent/IL94963A0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08Hydroxylamino compounds or their ethers or esters
    • C07C239/16Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
IL9094963A 1989-07-03 1990-07-03 Use of polyamines as ionic-channel regulating agents IL94963A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37577689A 1989-07-03 1989-07-03
US42733389A 1989-10-26 1989-10-26

Publications (1)

Publication Number Publication Date
IL94963A0 true IL94963A0 (en) 1991-06-10

Family

ID=27007189

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9094963A IL94963A0 (en) 1989-07-03 1990-07-03 Use of polyamines as ionic-channel regulating agents

Country Status (5)

Country Link
EP (1) EP0597830A1 (en)
AU (1) AU5957390A (en)
CA (1) CA2062810A1 (en)
IL (1) IL94963A0 (en)
WO (1) WO1991000853A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
US6011068A (en) * 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
EP1281702B1 (en) * 1991-08-23 2005-12-21 Nps Pharmaceuticals, Inc. Calcium receptor active molecules
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
EP0637237B1 (en) * 1993-02-23 2004-05-19 Brigham And Women's Hospital, Inc. Calcium receptor-active molecules
GB9320051D0 (en) * 1993-09-29 1993-11-17 Lilly Industries Ltd Pharmaceutical compounds
EP1553078A1 (en) 1994-10-21 2005-07-13 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
DE69739388D1 (en) * 1996-05-01 2009-06-10 Nps Pharma Inc Inorganic ionic receptor active compounds
WO1999003823A2 (en) 1997-07-15 1999-01-28 Oridigm Corporation Novel polyamine analogues as therapeutic and diagnostic agents
US7208528B1 (en) 1997-07-15 2007-04-24 Mediquest Therapeutics, Inc. Polyamine analogues as therapeutic and diagnostic agents
GB9726569D0 (en) 1997-12-16 1998-02-11 Univ Southampton Neuroprotective agents
CA2318004A1 (en) * 1999-09-15 2001-03-15 Oridigm Corporation Novel polyamine analogues as therapeutic and diagnostic agents
EP1337504A4 (en) * 2000-11-08 2005-10-05 Cellgate Inc Novel polyamine analog-amino acid conjugates useful as anticancer agents
AU2008201086B2 (en) * 2001-01-08 2011-06-09 Aminex Theapeutics, Inc. Hydrophobic Polyamine Analogs and Methods for their Use
US7432302B2 (en) 2001-01-08 2008-10-07 Mediquest Therapeutics, Inc. Composition containing polyamine transport inhibitor and use thereof
WO2002053519A2 (en) * 2001-01-08 2002-07-11 Mediquest Therapeutics, Inc. Hydrophobic polyamine analogs and methods for their use
USRE43327E1 (en) 2001-01-08 2012-04-24 Aminex Therapeutics, Inc. Hydrophobic polyamine analogs and methods for their use
FR2820136A1 (en) * 2001-01-26 2002-08-02 Aventis Pharma Sa NOVEL UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
GB0202645D0 (en) * 2002-02-05 2002-03-20 Univ Southampton Treatment of chronic neurodegenerative diseases
WO2006052229A1 (en) * 2004-11-03 2006-05-18 University Of Florida Aminated polyamines
US7423182B2 (en) 2004-11-03 2008-09-09 University Of Florida Aminated polyamines
FR2885129B1 (en) 2005-04-29 2007-06-15 Proskelia Sas NOVEL DERIVATIVES OF UREEE SUBSTITUTED WITH THIAZOLE OR BENZOTHIAZOLE, PROCESS FOR THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THE USE THEREOF
EP3432914B1 (en) 2016-03-25 2020-09-23 Aminex Therapeutics, Inc. Bioavailable polyamines
JP2023545674A (en) 2020-09-30 2023-10-31 アミネックス セラピューティクス, インコーポレイテッド Combined drug substance of polyamine transport inhibitor and DFMO

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591605A (en) * 1981-11-10 1986-05-27 Research Foundation Of State University Of New York Method and ingestible formulation for inhibiting the secretion of stomach acid

Also Published As

Publication number Publication date
CA2062810A1 (en) 1991-01-04
EP0597830A1 (en) 1994-05-25
AU5957390A (en) 1991-02-06
EP0597830A4 (en) 1992-07-22
WO1991000853A1 (en) 1991-01-24

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