IL86477A0 - Cyclic amine derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
Cyclic amine derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL86477A0 IL86477A0 IL86477A IL8647788A IL86477A0 IL 86477 A0 IL86477 A0 IL 86477A0 IL 86477 A IL86477 A IL 86477A IL 8647788 A IL8647788 A IL 8647788A IL 86477 A0 IL86477 A0 IL 86477A0
- Authority
- IL
- Israel
- Prior art keywords
- cyclic amine
- amine derivatives
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
Cyclic amine derivatives of the formula <IMAGE> in which A, B, E, G, R, R1, R2, m and n are as defined in Claim 1, their enantiomers, their diastereomers, their N-oxides and their acid addition salts have useful pharmacological properties, in particular a bradycardic action. The novel compounds can be prepared by processes known per se.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873717561 DE3717561A1 (en) | 1987-05-25 | 1987-05-25 | INDOL, ISOCHINOLINE AND BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
IL86477A0 true IL86477A0 (en) | 1988-11-15 |
IL86477A IL86477A (en) | 1992-07-15 |
Family
ID=6328351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL86477A IL86477A (en) | 1987-05-25 | 1988-05-24 | Cyclic amine derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0292840B1 (en) |
JP (1) | JP2634190B2 (en) |
KR (1) | KR960009432B1 (en) |
AT (1) | ATE126225T1 (en) |
AU (1) | AU607765B2 (en) |
CA (2) | CA1287226C (en) |
DD (1) | DD284678A5 (en) |
DE (2) | DE3717561A1 (en) |
DK (1) | DK282188A (en) |
ES (1) | ES2076147T3 (en) |
FI (1) | FI94343C (en) |
GR (1) | GR3017550T3 (en) |
HU (1) | HU198201B (en) |
IE (1) | IE68842B1 (en) |
IL (1) | IL86477A (en) |
IN (1) | IN169514B (en) |
NO (1) | NO171017C (en) |
NZ (1) | NZ224756A (en) |
PT (1) | PT87567B (en) |
SU (1) | SU1561823A3 (en) |
ZA (1) | ZA883680B (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3640641A1 (en) * | 1986-11-28 | 1988-07-14 | Thomae Gmbh Dr K | NEW HETEROAROMATIC AMINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
DE3835291A1 (en) * | 1988-04-19 | 1989-11-02 | Bayer Ag | 1,3-DISUBSTITUTED PYRROLIDINES |
US4902684A (en) * | 1988-06-20 | 1990-02-20 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
EP0351283A1 (en) * | 1988-07-12 | 1990-01-17 | Synthelabo | 2-[(4-Piperidinyl)methyl]-2,3-dihydro-1H-isoindole and 2,3,4,5-tetrahydro-1H-benzazepine derivatives, their preparation and therapeutical use |
IL89156A (en) * | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
US4952692A (en) * | 1989-04-04 | 1990-08-28 | E. R. Squibb & Sons, Inc. | Benzazepine derivatives |
US4946840A (en) * | 1989-04-06 | 1990-08-07 | E. R. Squibb & Sons, Inc. | Benzazepine and benzothiazepine derivatives |
KR927002347A (en) * | 1989-10-27 | 1992-09-03 | 레이몬드 지. 아너 | (N-phthalimidoalkyl) piperidine |
IE903857A1 (en) * | 1989-10-27 | 1991-05-08 | Du Pont Merck Pharma | (N-Phthalimidoalkyl)Piperidines |
US5356906A (en) * | 1989-10-27 | 1994-10-18 | The Du Pont Merck Pharmaceutical Company | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis |
EP0429341A3 (en) * | 1989-11-20 | 1991-11-13 | Rhone-Poulenc Sante | Heterocyclic derivatives, their preparation and pharmaceuticals containing them |
NZ540148A (en) | 2002-12-20 | 2007-11-30 | Glaxo Group Ltd | Benzazepine derivatives for the treatment of neurological disorders |
FR2868776B1 (en) * | 2004-04-13 | 2008-04-18 | Servier Lab | NOVEL PROCESS FOR THE SYNTHESIS OF 1,3-DIHYDRO-2H-3-BENZAZEPIN-2-ONE DERIVATIVES AND THE APPLICATION TO THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID |
CN101309905A (en) * | 2005-08-12 | 2008-11-19 | 阿斯利康(瑞典)有限公司 | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators |
AR059898A1 (en) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | DERIVATIVES OF 3-CIANO-PIRIDONA 1,4-DISUSTITUTED AND ITS USE AS ALLOSTERIC MODULATORS OF MGLUR2 RECEIVERS |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
CN101801951B (en) | 2007-09-14 | 2013-11-13 | 杨森制药有限公司 | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones |
RU2510396C2 (en) | 2008-09-02 | 2014-03-27 | Янссен Фармасьютикалз, Инк. | 3-azabicyclo[3,1,0]hexyl derivatives as modulators of metabotropic glutamate receptors |
AU2009319387B2 (en) | 2008-11-28 | 2012-05-10 | Addex Pharma S.A. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
RS53075B (en) | 2009-05-12 | 2014-04-30 | Janssen Pharmaceuticals Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
JP5707390B2 (en) | 2009-05-12 | 2015-04-30 | ジャンセン ファーマシューティカルズ, インコーポレイテッド | 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of the mGluR2 receptor |
EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
EP2643320B1 (en) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
KR20140057604A (en) | 2011-08-12 | 2014-05-13 | 베링거잉겔하임베트메디카게엠베하 | Funny current(if) inhibitors for use in a method of treating and preventing heart failure in feline |
JO3368B1 (en) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
JO3367B1 (en) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
DK3431106T3 (en) | 2014-01-21 | 2021-03-15 | Janssen Pharmaceutica Nv | COMBINATIONS INCLUDING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROP GLUTAMATERG SUBTYPE 2 RECEPTOR AND USE OF THESE |
ES2860298T3 (en) | 2014-01-21 | 2021-10-04 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators of metabotropic glutamatergic receptor subtype 2 and their use |
JP6931456B2 (en) * | 2017-04-03 | 2021-09-08 | 川崎化成工業株式会社 | Photopolymerization sensitizer containing 2-haloalkoxy-6-substituted oxynaphthalene compound and 2-haloalkoxy-6-substituted oxynaphthalene compound |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2639718A1 (en) * | 1976-09-03 | 1978-03-16 | Thomae Gmbh Dr K | NEW PHENYLAETHYLAMINE |
DE3119874A1 (en) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS" |
DE3418270A1 (en) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW AMINOTETRAL DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
DE3418271A1 (en) * | 1984-05-17 | 1985-11-21 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
DE3541811A1 (en) * | 1985-11-27 | 1987-06-04 | Thomae Gmbh Dr K | NEW CYCLIC AMINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
EP0306375A1 (en) * | 1987-08-07 | 1989-03-08 | Synthelabo | 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their use in therapy |
IL89156A (en) * | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
FR2686339B1 (en) * | 1992-01-22 | 1994-03-11 | Adir Cie | NOVEL NAPHTHALENIC AMIDES AND SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
-
1987
- 1987-05-25 DE DE19873717561 patent/DE3717561A1/en not_active Ceased
-
1988
- 1988-05-17 EP EP88107867A patent/EP0292840B1/en not_active Expired - Lifetime
- 1988-05-19 IN IN400/CAL/88A patent/IN169514B/en unknown
- 1988-05-20 DD DD88315962A patent/DD284678A5/en not_active IP Right Cessation
- 1988-05-20 CA CA000567453A patent/CA1287226C/en not_active Expired - Lifetime
- 1988-05-20 CA CA000567464A patent/CA1330993C/en not_active Expired - Fee Related
- 1988-05-23 FI FI882418A patent/FI94343C/en not_active IP Right Cessation
- 1988-05-23 NZ NZ224756A patent/NZ224756A/en unknown
- 1988-05-24 NO NO882258A patent/NO171017C/en unknown
- 1988-05-24 IE IE155988A patent/IE68842B1/en not_active IP Right Cessation
- 1988-05-24 PT PT87567A patent/PT87567B/en not_active IP Right Cessation
- 1988-05-24 JP JP63126910A patent/JP2634190B2/en not_active Expired - Lifetime
- 1988-05-24 ZA ZA883680A patent/ZA883680B/en unknown
- 1988-05-24 HU HU882647A patent/HU198201B/en not_active IP Right Cessation
- 1988-05-24 SU SU884355736A patent/SU1561823A3/en active
- 1988-05-24 AU AU16562/88A patent/AU607765B2/en not_active Ceased
- 1988-05-24 KR KR88006072A patent/KR960009432B1/en not_active IP Right Cessation
- 1988-05-24 DK DK282188A patent/DK282188A/en not_active Application Discontinuation
- 1988-05-24 IL IL86477A patent/IL86477A/en unknown
- 1988-05-24 DE DE3854280T patent/DE3854280D1/en not_active Expired - Fee Related
- 1988-05-24 AT AT88107867T patent/ATE126225T1/en not_active IP Right Cessation
- 1988-05-24 ES ES88107867T patent/ES2076147T3/en not_active Expired - Lifetime
-
1995
- 1995-09-28 GR GR950402663T patent/GR3017550T3/en unknown
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