IL82850A0 - Antihypertensive benzazepinones,their preparation and pharmaceutical compositions containing them - Google Patents

Antihypertensive benzazepinones,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL82850A0
IL82850A0 IL82850A IL8285087A IL82850A0 IL 82850 A0 IL82850 A0 IL 82850A0 IL 82850 A IL82850 A IL 82850A IL 8285087 A IL8285087 A IL 8285087A IL 82850 A0 IL82850 A0 IL 82850A0
Authority
IL
Israel
Prior art keywords
alkyl
preparation
substituted
independently hydrogen
benzazepinones
Prior art date
Application number
IL82850A
Other versions
IL82850A (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL82850A0 publication Critical patent/IL82850A0/en
Publication of IL82850A publication Critical patent/IL82850A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention relates to 6-oxopyrido(2,1-α) and (1,4)thiazino(3,4-a)(2)benzazepine-4-carboxylic acid derivatives and their preparation and also to intermediates which can be used in the preparation. The said derivatives have a pharmacological effect by inhibiting angiotensin converting enzyme and they can be used for treating hypertension. The novel compounds have the formula <IMAGE> in which R and R1 are independently hydrogen; alkyl; substituted alkyl; aryl; substituted aryl; heteroaryl; or substituted heteroaryloxy; R2 is hydrogen, straight-chain or branched alkyl, alkenyl or alkinyl; cycloalkyl, arylalkyl; or substituted alkyl; R3 is H, alkyl, phenyl or benzyl; R4 is a natural amino acid residue, and R3 and R4 have been linked, by way of the carbon atoms to which they are bonded, in order to form a 6-8-membered condensed ring which optionally contains a sulfur or oxygen atom, and R5 and R6 are independently hydrogen, hydroxyl; halogen; alkyl; or alkyloxy.
IL82850A 1986-06-13 1987-06-11 Antihypertensive benzazepinones,their preparation and pharmaceutical compositions containing them IL82850A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87375486A 1986-06-13 1986-06-13

Publications (2)

Publication Number Publication Date
IL82850A0 true IL82850A0 (en) 1987-12-20
IL82850A IL82850A (en) 1991-03-10

Family

ID=25362243

Family Applications (1)

Application Number Title Priority Date Filing Date
IL82850A IL82850A (en) 1986-06-13 1987-06-11 Antihypertensive benzazepinones,their preparation and pharmaceutical compositions containing them

Country Status (9)

Country Link
CN (1) CN1020612C (en)
AT (1) ATE81511T1 (en)
DE (1) DE3782190T2 (en)
FI (1) FI84481C (en)
HU (2) HU197328B (en)
IL (1) IL82850A (en)
NO (1) NO168584C (en)
NZ (1) NZ220649A (en)
PT (1) PT85070B (en)

Also Published As

Publication number Publication date
HUT44518A (en) 1988-03-28
HU197328B (en) 1989-03-28
NO168584C (en) 1992-03-11
CN87104166A (en) 1988-01-20
NO168584B (en) 1991-12-02
NO872461D0 (en) 1987-06-12
NO872461L (en) 1987-12-14
PT85070A (en) 1987-07-01
FI872613A0 (en) 1987-06-11
PT85070B (en) 1990-03-08
FI84481C (en) 1991-12-10
ATE81511T1 (en) 1992-10-15
FI872613A (en) 1987-12-14
HU201326B (en) 1990-10-28
DE3782190D1 (en) 1992-11-19
DE3782190T2 (en) 1993-02-25
IL82850A (en) 1991-03-10
CN1020612C (en) 1993-05-12
NZ220649A (en) 1990-09-26
FI84481B (en) 1991-08-30

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Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees
HC Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.