IL82264A - Water soluble polyvinyl lactam-drug complexes - Google Patents

Water soluble polyvinyl lactam-drug complexes

Info

Publication number
IL82264A
IL82264A IL82264A IL8226487A IL82264A IL 82264 A IL82264 A IL 82264A IL 82264 A IL82264 A IL 82264A IL 8226487 A IL8226487 A IL 8226487A IL 82264 A IL82264 A IL 82264A
Authority
IL
Israel
Prior art keywords
water soluble
soluble polyvinyl
drug complexes
polyvinyl lactam
lactam
Prior art date
Application number
IL82264A
Other versions
IL82264A0 (en
Original Assignee
Gaf Chemicals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/858,778 external-priority patent/US4758674A/en
Priority claimed from US06/858,978 external-priority patent/US4684698A/en
Priority claimed from US06/858,635 external-priority patent/US4713238A/en
Application filed by Gaf Chemicals Corp filed Critical Gaf Chemicals Corp
Publication of IL82264A0 publication Critical patent/IL82264A0/en
Publication of IL82264A publication Critical patent/IL82264A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/44Preparation of metal salts or ammonium salts
IL82264A 1986-05-02 1987-04-21 Water soluble polyvinyl lactam-drug complexes IL82264A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85897686A 1986-05-02 1986-05-02
US06/858,778 US4758674A (en) 1986-05-02 1986-05-02 Water soluble multicomplex of a poly(N-vinyl-2-pyrrolidone)-halogen complex and aminobenzoic acid
US06/858,978 US4684698A (en) 1986-05-02 1986-05-02 Water soluble multicomplex of chlorothiazide, furosemide and poly(N-vinyl-2-pyrrolidone)
US06/858,635 US4713238A (en) 1986-05-02 1986-05-02 Water soluble complex of a poly (vinyl lactam) and chlorothiazide and process for producing same

Publications (2)

Publication Number Publication Date
IL82264A0 IL82264A0 (en) 1987-10-30
IL82264A true IL82264A (en) 1991-04-15

Family

ID=27505932

Family Applications (1)

Application Number Title Priority Date Filing Date
IL82264A IL82264A (en) 1986-05-02 1987-04-21 Water soluble polyvinyl lactam-drug complexes

Country Status (6)

Country Link
EP (1) EP0305384A4 (en)
JP (1) JPH01502816A (en)
AU (1) AU603796B2 (en)
CA (1) CA1281651C (en)
IL (1) IL82264A (en)
WO (1) WO1987006464A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900775A (en) * 1988-02-29 1990-02-13 Gaf Chemicals Corporation Solubilization of complexes of water-insoluble organic compounds by aqueous solutions of polyvinylpyrrolidone

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR6681662D0 (en) * 1965-11-12 1973-10-25 S Santorelli THERAPEUTIC COMPOSITIONS AND PROCESS TO PREPARE THEM
US3957972A (en) * 1966-05-31 1976-05-18 Koninklijke Nederlandsche Gist-En Spiritusfabriek N.V. Stable solutions of oxytetracycline suitable for parenteral and peroral administration and process of preparation
US4128632A (en) * 1978-02-13 1978-12-05 Merck & Co., Inc. Solubilization of Rafoxanide
US4344934A (en) * 1978-11-20 1982-08-17 American Home Products Corporation Therapeutic compositions with enhanced bioavailability
US4213963A (en) * 1978-12-14 1980-07-22 Janssen Pharmaceutica N.V. Fluspirilene-containing compositions
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
US4542025A (en) * 1982-07-29 1985-09-17 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
DE3234350A1 (en) * 1982-09-16 1984-03-22 Roland 3400 Göttingen Hemmann Process for the preparation of a germicidal and surface-anaesthetic medicinal composition
US4898729A (en) * 1983-12-09 1990-02-06 Euroceltique, S.A. Treatment of hypertension, compounds and compositions for antihypertension and diuresis

Also Published As

Publication number Publication date
IL82264A0 (en) 1987-10-30
EP0305384A4 (en) 1989-06-13
WO1987006464A1 (en) 1987-11-05
AU7280887A (en) 1987-11-24
AU603796B2 (en) 1990-11-29
EP0305384A1 (en) 1989-03-08
JPH01502816A (en) 1989-09-28
CA1281651C (en) 1991-03-19

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