IL78604A - Process for the preparation of homogeneous,pure alpha-interferon,alpha-interferon produced thereby and pharmaceutical compositions containing it - Google Patents

Process for the preparation of homogeneous,pure alpha-interferon,alpha-interferon produced thereby and pharmaceutical compositions containing it

Info

Publication number
IL78604A
IL78604A IL78604A IL7860486A IL78604A IL 78604 A IL78604 A IL 78604A IL 78604 A IL78604 A IL 78604A IL 7860486 A IL7860486 A IL 7860486A IL 78604 A IL78604 A IL 78604A
Authority
IL
Israel
Prior art keywords
interferon
alpha
homogeneous
preparation
pharmaceutical compositions
Prior art date
Application number
IL78604A
Other versions
IL78604A0 (en
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of IL78604A0 publication Critical patent/IL78604A0/en
Publication of IL78604A publication Critical patent/IL78604A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The process yields a highly pure, non-immunogenic, homogeneous alpha -interferon which has antiviral and immunoregulatory activity.
IL78604A 1985-04-27 1986-04-23 Process for the preparation of homogeneous,pure alpha-interferon,alpha-interferon produced thereby and pharmaceutical compositions containing it IL78604A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3515336A DE3515336C2 (en) 1985-04-27 1985-04-27 Process for the preparation and purification of â-interferon

Publications (2)

Publication Number Publication Date
IL78604A0 IL78604A0 (en) 1986-08-31
IL78604A true IL78604A (en) 1991-11-21

Family

ID=6269344

Family Applications (1)

Application Number Title Priority Date Filing Date
IL78604A IL78604A (en) 1985-04-27 1986-04-23 Process for the preparation of homogeneous,pure alpha-interferon,alpha-interferon produced thereby and pharmaceutical compositions containing it

Country Status (20)

Country Link
EP (1) EP0203382B1 (en)
JP (1) JP2566919B2 (en)
KR (1) KR940010024B1 (en)
AT (1) ATE94588T1 (en)
AU (1) AU598460B2 (en)
CA (1) CA1340281C (en)
DE (2) DE3515336C2 (en)
DK (1) DK186486A (en)
ES (1) ES8707554A1 (en)
FI (1) FI861748A (en)
GR (1) GR861093B (en)
HU (1) HU202883B (en)
IE (1) IE61444B1 (en)
IL (1) IL78604A (en)
NO (1) NO166727C (en)
NZ (1) NZ215969A (en)
PH (1) PH30912A (en)
PT (1) PT82452B (en)
SU (1) SU1591814A3 (en)
ZA (1) ZA863108B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
DE3813124A1 (en) * 1988-04-15 1989-10-26 Krieg Benno Distillable buffer solutions and their uses
ES2161793T3 (en) * 1994-04-09 2001-12-16 Hoffmann La Roche PROCESS FOR THE PRODUCTION OF ALFA-INTERFERONA.
KR100369582B1 (en) * 1995-09-04 2003-04-03 동아제약 주식회사 Purification method of recombinant alpha-interferon
JP4468585B2 (en) * 1998-11-12 2010-05-26 シェーリング コーポレイション Methods for conversion of interferon isoforms and their products
ITBO20010426A1 (en) * 2001-07-06 2003-01-06 Alfa Wassermann Spa PHARMACOLOGICALLY ACTIVE PROTEIN PURIFICATION PROCESS BY CATIONIC EXCHANGE CHROMATOGRAPHY
PT1539798E (en) 2002-09-06 2011-02-23 Genentech Inc Process for protein extraction
GB0818228D0 (en) * 2008-10-06 2008-11-12 Avecia Biolog Ltd Purification process
CN114814000A (en) * 2022-03-30 2022-07-29 深圳科兴药业有限公司 Method for detecting content of recombinant human interferon

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA796175B (en) * 1978-11-24 1980-11-26 Hoffmann La Roche Purified proteins and process therefor
FI77877C (en) * 1979-04-20 1989-05-10 Technobiotic Ltd Process for the preparation and purification of human Le-shaped interferon protein.
ZA814375B (en) * 1980-07-01 1982-07-28 Hoffmann La Roche Interferons and process for their preparation
CH651308A5 (en) * 1980-07-01 1985-09-13 Hoffmann La Roche INTERFERON AND THEIR PRODUCTION.
US4364863A (en) * 1980-12-29 1982-12-21 Schering Corporation Extraction of interferon from bacteria
DE3220116A1 (en) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach MICROBIOLOGICALLY MANUFACTURED (ALPHA) AND SS INTERFERONES, DNA SEQUENCES CODING FOR THESE INTERFERONES, MICROORGANISMS CONTAINING THIS GENETIC INFORMATION, AND METHOD FOR THE PRODUCTION THEREOF
US4534906A (en) * 1982-11-01 1985-08-13 Genentech, Inc. Removal of impurities from human leukocyte interferon preparations
EP0116201B1 (en) * 1983-01-12 1992-04-22 Chiron Corporation Secretory expression in eukaryotes
DE3306060A1 (en) * 1983-02-22 1984-08-23 Boehringer Ingelheim International GmbH, 6507 Ingelheim NEW IMMUNGLOBULIN-PRODUCING HYBRID CELL LINES, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
NZ215969A (en) 1990-08-28
JPS61282098A (en) 1986-12-12
NO166727C (en) 1991-08-28
DE3515336C2 (en) 1994-01-20
PT82452A (en) 1986-05-01
JP2566919B2 (en) 1996-12-25
NO861635L (en) 1986-10-28
EP0203382A3 (en) 1988-04-27
ATE94588T1 (en) 1993-10-15
PH30912A (en) 1997-12-23
CA1340281C (en) 1998-12-22
PT82452B (en) 1988-11-30
HU202883B (en) 1991-04-29
ZA863108B (en) 1987-12-30
HUT41073A (en) 1987-03-30
AU5677586A (en) 1986-10-30
FI861748A (en) 1986-10-28
DE3689008D1 (en) 1993-10-21
ES554372A0 (en) 1987-08-01
SU1591814A3 (en) 1990-09-07
GR861093B (en) 1986-08-26
KR940010024B1 (en) 1994-10-20
EP0203382A2 (en) 1986-12-03
DK186486A (en) 1986-10-28
FI861748A0 (en) 1986-04-25
DE3515336A1 (en) 1987-01-22
IE61444B1 (en) 1994-11-02
IL78604A0 (en) 1986-08-31
AU598460B2 (en) 1990-06-28
IE861095L (en) 1986-10-27
DK186486D0 (en) 1986-04-23
NO166727B (en) 1991-05-21
ES8707554A1 (en) 1987-08-01
EP0203382B1 (en) 1993-09-15
KR860008270A (en) 1986-11-14

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Legal Events

Date Code Title Description
KB Patent renewed
RH Patent void