IL72265A - 2-piperazino-4,6,7-trisubstituted pteridines,their preparation and pharmaceutical compositions containing them - Google Patents

2-piperazino-4,6,7-trisubstituted pteridines,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL72265A
IL72265A IL72265A IL7226584A IL72265A IL 72265 A IL72265 A IL 72265A IL 72265 A IL72265 A IL 72265A IL 7226584 A IL7226584 A IL 7226584A IL 72265 A IL72265 A IL 72265A
Authority
IL
Israel
Prior art keywords
group
piperazino
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL72265A
Other versions
IL72265A0 (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of IL72265A0 publication Critical patent/IL72265A0/en
Publication of IL72265A publication Critical patent/IL72265A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)

Abstract

New 2-piperazino-pteridines of general formula <IMAGE> are described wherein R1 represents a phenylalkylamino, alkylamino or dialkylamino group, a piperidino, morpholino, thiomorpholino, or 1-oxidothiomorpholino group, R2 represents a dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxidothiomorpholino group and R3 represents a halogen atom, an alkoxy, alkylthio, phenylalkoxy or phenylalkylthio group, wherein the alkyl moiety may contain from 1 to 3 carbon atoms, and the acid addition salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable pharmacological properties, particularly antithrombotic and metastasis-inhibiting effects. Processes for preparing the compounds of formula (I) are also described.
IL72265A 1983-07-02 1984-06-29 2-piperazino-4,6,7-trisubstituted pteridines,their preparation and pharmaceutical compositions containing them IL72265A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833323932 DE3323932A1 (en) 1983-07-02 1983-07-02 NEW 2-PIPERAZINO-PTERIDINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THIS COMPOUND

Publications (2)

Publication Number Publication Date
IL72265A0 IL72265A0 (en) 1984-10-31
IL72265A true IL72265A (en) 1987-08-31

Family

ID=6203017

Family Applications (1)

Application Number Title Priority Date Filing Date
IL72265A IL72265A (en) 1983-07-02 1984-06-29 2-piperazino-4,6,7-trisubstituted pteridines,their preparation and pharmaceutical compositions containing them

Country Status (17)

Country Link
EP (1) EP0134922B1 (en)
JP (1) JPS6025991A (en)
AT (1) ATE39253T1 (en)
AU (1) AU565105B2 (en)
CA (1) CA1233179A (en)
DD (1) DD229990A5 (en)
DE (2) DE3323932A1 (en)
DK (1) DK159113C (en)
ES (2) ES8503352A1 (en)
FI (1) FI80454C (en)
GB (1) GB2143232B (en)
HU (1) HU190932B (en)
IL (1) IL72265A (en)
NO (1) NO160920C (en)
NZ (1) NZ208725A (en)
PH (1) PH22493A (en)
ZA (1) ZA844968B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3445298A1 (en) * 1984-12-12 1986-06-12 Dr. Karl Thomae Gmbh, 7950 Biberach NEW PTERIDINE, METHOD FOR THE PRODUCTION AND USE THEREOF AS INTERMEDIATE PRODUCTS OR AS A MEDICINAL PRODUCT
DE3540952C2 (en) * 1985-11-19 1997-08-14 Thomae Gmbh Dr K 2-Piperazino-pteridines, process for their preparation and medicaments containing these compounds
US7276506B2 (en) 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
DE10202468A1 (en) * 2002-01-23 2004-09-30 Faustus Forschungs Cie. Translational Cancer Research Gmbh Pteridine derivatives, process for their preparation and their use
CA2534151A1 (en) * 2003-08-29 2005-03-10 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
GB2407089A (en) * 2003-10-17 2005-04-20 4 Aza Bioscience Nv Pteridine derivatives
DE102004057594A1 (en) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substitute pteridine for the treatment of inflammatory diseases
DE102004057595A1 (en) 2004-11-29 2006-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
DE102004057645A1 (en) * 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg New substituted pteridine compounds, useful as phosphodiesterase 4 inhibitors for treating e.g. inflammatory diseases, cancer, asthma, ulcerative colitis, depression and schizophrenia
DE102004057618A1 (en) 2004-11-29 2006-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Substituted pteridines for the treatment of inflammatory diseases
WO2007135026A2 (en) 2006-05-24 2007-11-29 Boehringer Ingelheim International Gmbh Substituted pteridines as therapeutic agents
ATE549338T1 (en) * 2006-05-24 2012-03-15 Boehringer Ingelheim Int SUBSTITUTED PTERIDINES SUBSTITUTED WITH A FOUR-MEMBER HETEROCYCLE
US20090318456A1 (en) * 2006-07-06 2009-12-24 Gilead Sciences, Inc. Substituted pteridines for the treatment and prevention of viral infections
WO2008009079A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
DK3321265T3 (en) 2015-03-04 2020-06-08 Gilead Sciences Inc 4,6-DIAMINO-PYRIDO [3,2-D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF TOLL-LIKE RECEPTORS
MA46093A (en) 2016-09-02 2021-05-19 Gilead Sciences Inc TOLL-TYPE RECEIVER MODULATING COMPOUNDS
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
TW202210480A (en) 2019-04-17 2022-03-16 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202212339A (en) 2019-04-17 2022-04-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TW202115056A (en) 2019-06-28 2021-04-16 美商基利科學股份有限公司 Processes for preparing toll-like receptor modulator compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940972A (en) * 1957-06-27 1960-06-14 Thomae Gmbh Dr K Tri-and tetra-substituted pteridine derivatives
FR1352111A (en) * 1962-01-25 1964-02-14 Lumiere Lab Triamino pteridines and their preparation

Also Published As

Publication number Publication date
ATE39253T1 (en) 1988-12-15
NO842631L (en) 1985-01-03
DE3323932A1 (en) 1985-01-10
CA1233179A (en) 1988-02-23
PH22493A (en) 1988-09-12
FI80454B (en) 1990-02-28
HUT34487A (en) 1985-03-28
GB2143232A (en) 1985-02-06
DE3475620D1 (en) 1989-01-19
JPS6025991A (en) 1985-02-08
DD229990A5 (en) 1985-11-20
DK316284D0 (en) 1984-06-28
FI842622A (en) 1985-01-03
ES8601205A1 (en) 1985-10-16
EP0134922A1 (en) 1985-03-27
GB8416682D0 (en) 1984-08-01
ES533298A0 (en) 1985-02-16
EP0134922B1 (en) 1988-12-14
NO160920C (en) 1989-06-14
ES537785A0 (en) 1985-10-16
DK159113B (en) 1990-09-03
DK159113C (en) 1991-02-18
FI80454C (en) 1990-06-11
IL72265A0 (en) 1984-10-31
GB2143232B (en) 1986-11-05
NZ208725A (en) 1988-10-28
FI842622A0 (en) 1984-06-29
ZA844968B (en) 1986-03-26
AU3009284A (en) 1985-01-03
HU190932B (en) 1986-12-28
DK316284A (en) 1985-01-03
ES8503352A1 (en) 1985-02-16
NO160920B (en) 1989-03-06
AU565105B2 (en) 1987-09-03

Similar Documents

Publication Publication Date Title
IL72265A (en) 2-piperazino-4,6,7-trisubstituted pteridines,their preparation and pharmaceutical compositions containing them
EP0163599A3 (en) Pyrimidopyrimidine derivatives, processes for producing them, pharmaceutical compositions containing them and their use as anti-allergic agents
AU584759B2 (en) New diphosphonic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL63613A (en) Dihydrohalo oxo-pyrido(1,2,3-de)(1,4)benzoxazine carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
ES8405787A1 (en) Antihypertensives.
DE3061424D1 (en) 8-phenyl purines, their preparation and medicaments containing them
IL69292A (en) Muramyl peptides substituted by 1,2-diacylated-sn-glycero-3-hydroxyphosphoryl,their manufacture and pharmaceutical compositions containing them
AU579869B2 (en) 4-amino-8-alkylthio-2-piperazino-pyrimido ``5,4-d`` pyrimidines
ZA88446B (en) Allylmercaptoacetylsydnonimines,processes for their preparation, and their use
ES476645A1 (en) Amino derivatives of pyrazolo [1,5-a]s-triazine, and their therapeutic applications
ES8403129A1 (en) Substituted thienobenzodiazepinones, process for preparing them and medicines containing them.
ZA881383B (en) 2-(2,3-dihydro-2-oxo-3-benzofuranyl)acetic acid derivatives,processes for preparing them and the pharmaceutical compositions which contain them
GB2016002A (en) Amino derivatives of pyrazolo[1,5-A]S.triazine
DE3362248D1 (en) Ergoline derivatives, process for producing the ergoline derivatives and pharmaceutical compositions containing them
AU1234588A (en) New acetamides derived from 2,3-dihydro-3-phenyl-2-benzofuranone, processes for preparing them and the pharmaceutical compositions which contain them