IL68366A - Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture - Google Patents
Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell cultureInfo
- Publication number
- IL68366A IL68366A IL68366A IL6836683A IL68366A IL 68366 A IL68366 A IL 68366A IL 68366 A IL68366 A IL 68366A IL 6836683 A IL6836683 A IL 6836683A IL 68366 A IL68366 A IL 68366A
- Authority
- IL
- Israel
- Prior art keywords
- microorganism
- expressing
- protein
- cell culture
- gene encoding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Microbiology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL8323683A IL83236A (en) | 1982-04-15 | 1983-04-12 | Preparation of bioactive human urokinase protein |
IL83236A IL83236A0 (en) | 1982-04-15 | 1987-07-17 | Preparation of functional human urokinase proteins |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36877382A | 1982-04-15 | 1982-04-15 | |
US47493083A | 1983-03-14 | 1983-03-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL68366A0 IL68366A0 (en) | 1983-07-31 |
IL68366A true IL68366A (en) | 1990-08-31 |
Family
ID=27004326
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL68366A IL68366A (en) | 1982-04-15 | 1983-04-12 | Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture |
IL83236A IL83236A0 (en) | 1982-04-15 | 1987-07-17 | Preparation of functional human urokinase proteins |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL83236A IL83236A0 (en) | 1982-04-15 | 1987-07-17 | Preparation of functional human urokinase proteins |
Country Status (20)
Country | Link |
---|---|
EP (2) | EP0092182B1 (fr) |
JP (3) | JPH0655145B2 (fr) |
AT (2) | ATE112802T1 (fr) |
AU (1) | AU573523B2 (fr) |
BR (1) | BR8301918A (fr) |
CA (1) | CA1341301C (fr) |
DE (2) | DE3382760T2 (fr) |
DK (1) | DK173910B1 (fr) |
ES (3) | ES521418A0 (fr) |
FI (1) | FI88932C (fr) |
GR (1) | GR78180B (fr) |
HK (1) | HK38297A (fr) |
IE (1) | IE64536B1 (fr) |
IL (2) | IL68366A (fr) |
MY (1) | MY102472A (fr) |
NO (1) | NO831317L (fr) |
NZ (1) | NZ203869A (fr) |
PH (4) | PH24783A (fr) |
PT (1) | PT76546B (fr) |
YU (1) | YU45128B (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4370417A (en) * | 1980-04-03 | 1983-01-25 | Abbott Laboratories | Recombinant deoxyribonucleic acid which codes for plasminogen activator |
AU587960B2 (en) * | 1983-06-24 | 1989-09-07 | Genentech Inc. | Procaryotic carbonyl hydrolases |
NZ208612A (en) * | 1983-06-24 | 1991-09-25 | Genentech Inc | Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations |
EP0139447B1 (fr) * | 1983-09-13 | 1992-12-30 | The Green Cross Corporation | Procéde pour la préparation du Zymogène d'urokinase |
JPS61177987A (ja) * | 1985-01-31 | 1986-08-09 | Green Cross Corp:The | ヒトウロキナ−ゼの製造方法 |
JPS60180591A (ja) * | 1984-02-27 | 1985-09-14 | Green Cross Corp:The | ヒトウロキナ−ゼのdνa配列,プラスミド,宿主 |
DE3585097D1 (de) * | 1984-02-27 | 1992-02-20 | Green Cross Corp | Herstellung menschlicher urokinase. |
JPS61181377A (ja) * | 1985-01-25 | 1986-08-14 | Sagami Chem Res Center | ヒトウロキナ−ゼ遺伝子 |
EP0210279B1 (fr) * | 1985-01-25 | 1991-08-14 | Sagami Chemical Research Center | Prourokinase humaine stabilisee |
US5219569A (en) * | 1985-04-22 | 1993-06-15 | Genentech, Inc. | Protease resistant urokinase |
US4997766A (en) * | 1986-07-11 | 1991-03-05 | American Home Products Corporation | Poly-kringle plasminogen activator |
US4916071A (en) * | 1985-08-14 | 1990-04-10 | American Home Products Corporation | Poly-kringle plasminogen activator |
JPS62149625A (ja) * | 1985-12-25 | 1987-07-03 | Green Cross Corp:The | 生理活性物質の製造方法 |
DE3613401A1 (de) * | 1986-04-21 | 1987-12-17 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von plasminogen-aktivatoren in prokaryonten |
NL8601240A (nl) * | 1986-05-15 | 1987-12-01 | Leuven Res & Dev Vzw | Plasminogeenactivator en trombolytisch geneesmiddel. |
GB8623823D0 (en) * | 1986-10-03 | 1986-11-05 | Sandoz Ltd | Therapeutic lysis of fibrin blood clots |
JPS63105675A (ja) * | 1986-10-23 | 1988-05-10 | Green Cross Corp:The | ヒトウロキナ−ゼの製造方法 |
ZA879286B (en) | 1986-12-16 | 1988-10-26 | Smith Kline Rit | New plasminogen activators |
EP0299053A1 (fr) * | 1987-01-30 | 1989-01-18 | American Home Products Corporation | Activateurs du plasminogene du facteur de croissance des-epidermique |
MY103358A (en) * | 1987-04-15 | 1993-06-30 | Novartis Ag | Process for the production of protiens. |
US5188829A (en) * | 1987-08-19 | 1993-02-23 | Sagami Chemical Research Center | Rapidly acting prourokinase |
AU2334088A (en) * | 1987-10-02 | 1989-05-18 | Zymogenetics Inc. | Bar1 secretion signal |
EP0316068A1 (fr) * | 1987-10-09 | 1989-05-17 | Collaborative Research Inc. | Activateur du plasminogène modifié de bas poids moléculaire et méthode pour sa préparation |
US4999194A (en) * | 1988-01-14 | 1991-03-12 | Collaborative Research, Inc. | Two-chain urokinase plasminogen activators for treatment of thrombotic disease |
US4920051A (en) * | 1988-02-03 | 1990-04-24 | Damon Biotech, Inc. | Recovery of urokinase compounds |
IE901849A1 (en) | 1989-07-19 | 1991-06-19 | Gruenenthal Gmbh | Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator |
CA2027936C (fr) | 1989-10-23 | 2001-07-24 | Smithkline Beecham Corporation | Peptides cycliques anti-agregants |
CA2067821A1 (fr) * | 1989-10-24 | 1991-04-25 | Cetus Oncology Corporation | Mecanisme infectieux d'administration d'un medicament faisant appel a des vecteurs retroviraux recombinants |
DE4101736A1 (de) * | 1991-01-22 | 1992-07-23 | Gruenenthal Gmbh | Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung |
US5888814A (en) * | 1994-06-06 | 1999-03-30 | Chiron Corporation | Recombinant host cells encoding TNF proteins |
JP2003525578A (ja) * | 1998-06-26 | 2003-09-02 | クロプテック・デヴェロップメント・コーポレイション | 植物ベースの発現システムにおけるウロキナーゼの製造 |
US6833357B2 (en) | 2000-06-20 | 2004-12-21 | The Trustees Of The University Of Pennsylvania | Compositions and methods for modulating muscle cell and tissue contractility |
AU2006304804B2 (en) * | 2005-10-21 | 2011-06-02 | Vertex Pharmaceuticals Incorporated | Modified proteases that inhibit complement activation |
SG175602A1 (en) | 2006-07-05 | 2011-11-28 | Catalyst Biosciences Inc | Protease screening methods and proteases identified thereby |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981001417A1 (fr) * | 1979-11-13 | 1981-05-28 | S Husain | Isolation d'activateurs plasminogenes utiles comme agents therapeutiques et diagnostiques |
US4321363A (en) * | 1980-02-21 | 1982-03-23 | Nippon Soda Company Limited | Adsorbent for urokinase containing agarose |
US4370417A (en) * | 1980-04-03 | 1983-01-25 | Abbott Laboratories | Recombinant deoxyribonucleic acid which codes for plasminogen activator |
US4506013A (en) * | 1980-10-03 | 1985-03-19 | Eli Lilly And Company | Stabilizing and selecting recombinant DNA host cells |
EP0143081B1 (fr) * | 1983-11-21 | 1989-08-23 | Ciba-Geigy Ag | Synthèse d'activateur du plasminogene tissulaire(TPA) par levure |
-
1983
- 1983-04-12 IL IL68366A patent/IL68366A/xx not_active IP Right Cessation
- 1983-04-12 GR GR71061A patent/GR78180B/el unknown
- 1983-04-12 FI FI831228A patent/FI88932C/fi not_active IP Right Cessation
- 1983-04-13 PT PT76546A patent/PT76546B/pt unknown
- 1983-04-13 PH PH28772A patent/PH24783A/en unknown
- 1983-04-13 NZ NZ203869A patent/NZ203869A/en unknown
- 1983-04-13 ES ES521418A patent/ES521418A0/es active Granted
- 1983-04-14 NO NO831317A patent/NO831317L/no unknown
- 1983-04-14 JP JP58066284A patent/JPH0655145B2/ja not_active Expired - Lifetime
- 1983-04-14 AT AT83103629T patent/ATE112802T1/de not_active IP Right Cessation
- 1983-04-14 DE DE3382760T patent/DE3382760T2/de not_active Expired - Lifetime
- 1983-04-14 DK DK198301636A patent/DK173910B1/da not_active IP Right Cessation
- 1983-04-14 AU AU13524/83A patent/AU573523B2/en not_active Expired
- 1983-04-14 EP EP83103629A patent/EP0092182B1/fr not_active Expired - Lifetime
- 1983-04-14 IE IE85083A patent/IE64536B1/en not_active IP Right Cessation
- 1983-04-14 EP EP94104777A patent/EP0620279B1/fr not_active Expired - Lifetime
- 1983-04-14 CA CA000425894A patent/CA1341301C/fr not_active Expired - Lifetime
- 1983-04-14 AT AT94104777T patent/ATE232237T1/de not_active IP Right Cessation
- 1983-04-14 DE DE3382837T patent/DE3382837T2/de not_active Expired - Lifetime
- 1983-04-14 BR BR8301918A patent/BR8301918A/pt unknown
- 1983-04-15 YU YU868/83A patent/YU45128B/xx unknown
-
1984
- 1984-07-02 ES ES533925A patent/ES8602121A1/es not_active Expired
- 1984-07-02 ES ES533924A patent/ES533924A0/es active Granted
- 1984-07-24 PH PH31025A patent/PH25120A/en unknown
- 1984-07-24 PH PH31022A patent/PH22461A/en unknown
- 1984-07-24 PH PH31024A patent/PH25312A/en unknown
-
1987
- 1987-07-17 IL IL83236A patent/IL83236A0/xx unknown
- 1987-09-28 MY MYPI87002076A patent/MY102472A/en unknown
-
1992
- 1992-01-09 JP JP4002252A patent/JPH0824579B2/ja not_active Expired - Lifetime
-
1994
- 1994-02-08 JP JP6014310A patent/JP2584192B2/ja not_active Expired - Lifetime
-
1997
- 1997-03-27 HK HK38297A patent/HK38297A/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
KB20 | Patent renewed for 20 years | ||
EXP | Patent expired |