IL44109A - Capsules and their manufacture - Google Patents
Capsules and their manufactureInfo
- Publication number
- IL44109A IL44109A IL44109A IL4410974A IL44109A IL 44109 A IL44109 A IL 44109A IL 44109 A IL44109 A IL 44109A IL 4410974 A IL4410974 A IL 4410974A IL 44109 A IL44109 A IL 44109A
- Authority
- IL
- Israel
- Prior art keywords
- capsule
- cap
- film
- forming material
- pins
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/074—Filling capsules; Related operations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
- A61J3/077—Manufacturing capsule shells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Manufacturing & Machinery (AREA)
- Mechanical Engineering (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- General Preparation And Processing Of Foods (AREA)
Claims (13)
1. A capsule comprising a body having a closed-end v/all and a side wall having a generally cylindrical open-end portion, and a cap having a closed-end wall and a generally cylindrical side wall closely t el escopi cal ly received over the open end of the., body, said body and cap being separable and re-closable after manufacture so as to enable a product to be inserted into said body, the walls of said body and cap being composed of two layers, the materials constituting said layers being soluble at pH ranges which are different but overlapping.
2. Capsule as claimed in Claim 1, wherein the inner of said wo layers comprising the walls of the capsule is soluble in solutions of acidic and basic pH and the outer of said two layers is only soluble at a pH greater than 3.5.
3. Capsule as claimed in Claim 2, wherein said inner layer is of gelatin.
4. Capsule as claimed in Claim 2, wherein said outer layer comprises a film-forming material selected from salol , benzoin, n-butyl stearate, carnuba wax, shellac or mixtures thereof,
5. Capsule as claimed in Claim 2, wherein said outer layer comprises a synthetic film-forming material selected from methacrylic acid polymers, carboxyvinyl polymers, partial esters of maleic anhydr ide /v i ny1 alkyl ether and maleic anliydr i d e /a.lken copolymers, hydroxypropy1 methyl cellulose phthalate, cellulose benzoacetate and cellulose acetate phthalate.
6. Capsule as claimed in Claim 2, wherein said inner layer has a double wal l thickness of 0.10 to 0.20mm and is made of gelatin, and said outer layer has a double wall thickness of fro 0.020 to 0.060mm and is made of a synthetic film-forming material as defi ed in Claim 5. 44109-2 ISRAEL G.1.095
7. Capsule as claimed in claim 6, wherein said film-forming material is cellulose acetate phthalate.
8. A capsule as claimed in any one of claim 2 to 7, containing a medicament and having the junction of the cap and body of said capsule sealed by a circu ferential band which is only soluble at a pH greater than 3.5.
9. Method for manufacturing a capsule as claimed in any one of claims 1 to 7, characterised by the steps of : (i) dipping a capsule body pin and a capsule cap pin into a solution of a first film-forming material to a pre-determined depth; (ii) withdrawing said pins and allowing the adherent layer of said first film-forming material to set; (iii) partially or wholly drying the first adherent layer on said pins; (iv) re-dipping said pins into a solution of a second film-forming material in which said first film-forming material is substantially insoluble, said first and second film-forming materials being soluble at pH ranges which are different but overlapping; (v) withdrawing said pins and allowing the adherent layer of said seconcjl film-forming material to set; (vi ) partially or wholly drying the second adherent layer on said pins; (vii) pulling or stripping the resultant two-layer body and cap shells from their respective pins, said body and cap shells each having a closed-end wall and a generally cylindrical open-end portion; (viii) cutting said body and cap shells to the desired length; and (ix) sliding said cap shell telescopically over the open-end portion of said body shell.
10. Method according to claim 9 for manufacturitig a two-part hard gelatin capsule resistant to dissolution in gastric juices, wherein the first film-forming material is gelatin, and the second film-forming material is resistant to dissolution at pH values less than 3.5 but is soluble at higher pH values. 44109-2
11. Method as claimed in claims 9 or 10, wherein step (iv) is preceded by dipping the pins in a solution of a substance capable of promoting adhesion of the inner and outer layers.
12. Method as claimed in claims 9 or 10, wherein, prior tostep (vii), steps (iv) to (vi) are repeated.
13. Method of manufacturing a capsule according to claim 8 which method comprises separating the body and cap of said capsules, filling said pharmaceutical preparation into said body, refitting said cap to said body and sealing said cap and body together by applying a circumferential band to the external junction thereof, said band being comprised of a material resistant to dissolution at pH values less than 3.5.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB714173A GB1455884A (en) | 1973-02-14 | 1973-02-14 | Production of capsules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL44109A0 IL44109A0 (en) | 1974-05-16 |
| IL44109A true IL44109A (en) | 1976-10-31 |
Family
ID=9827403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL44109A IL44109A (en) | 1973-02-14 | 1974-01-29 | Capsules and their manufacture |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5029734A (en) |
| AT (1) | AT336794B (en) |
| BE (1) | BE810991A (en) |
| CA (1) | CA1028951A (en) |
| CH (1) | CH592447A5 (en) |
| CS (1) | CS191908B2 (en) |
| DD (1) | DD109509A5 (en) |
| DE (1) | DE2406021A1 (en) |
| DK (1) | DK137166B (en) |
| ES (2) | ES423259A1 (en) |
| FR (1) | FR2216985B1 (en) |
| GB (1) | GB1455884A (en) |
| HU (1) | HU172393B (en) |
| IE (1) | IE38792B1 (en) |
| IL (1) | IL44109A (en) |
| NL (1) | NL7401812A (en) |
| SE (1) | SE413836B (en) |
| YU (1) | YU36774A (en) |
| ZA (1) | ZA74543B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4581875A (en) * | 1983-06-20 | 1986-04-15 | Cosden Technology, Inc. | Process for forming tamper-resistant tamper-indicative capsules |
| JPH01232963A (en) * | 1988-03-14 | 1989-09-18 | Arimento Kogyo Kk | Double-layer soft capsule and preparation thereof |
| AT397764B (en) * | 1992-07-23 | 1994-06-27 | Schlegel Christoph | Device for automatic opening and emptying of capsules |
| TW245641B (en) * | 1993-04-26 | 1995-04-21 | Takeda Pharm Industry Co | |
| FR2771660B1 (en) * | 1997-11-28 | 2000-01-14 | Industrialisation Concept Et M | PROCESS FOR FORMING AND DEPOSITING A DETERMINED DOSE OF A LIQUID OR PASTY PRODUCT AND INSTALLATION FOR IMPLEMENTING THE PROCESS |
| GB2398499B (en) * | 2000-02-16 | 2004-11-24 | Bioprogress Technology Ltd | Two layer capsules |
| GB0003424D0 (en) * | 2000-02-16 | 2000-04-05 | Bioprogress Tech Int Inc | A controlled release capsule |
| DE102009010091A1 (en) * | 2009-02-24 | 2010-08-26 | Beiersdorf Ag | Stabilized peeling capsule |
| ES2596222T3 (en) * | 2011-10-06 | 2017-01-05 | Binutra Incorporated | Method and apparatus for manufacturing a capsule |
| CN104905967B (en) * | 2015-05-23 | 2019-04-16 | 浙江益立胶囊股份有限公司 | Production mould for the double-deck enteric hollow capsule |
| EP4251126A1 (en) | 2020-11-25 | 2023-10-04 | Capsugel Belgium NV | Double layered delayed-release hard capsules |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB493934A (en) * | 1936-01-17 | 1938-10-17 | Hugo Remmler Ag Dr | Improvements in and relating to methods of treating medicaments |
| GB638284A (en) * | 1946-03-25 | 1950-06-07 | Parke Davis & Co | Improvements in or relating to enteric capsules |
-
1973
- 1973-02-14 GB GB714173A patent/GB1455884A/en not_active Expired
-
1974
- 1974-01-22 CA CA190,680A patent/CA1028951A/en not_active Expired
- 1974-01-24 IE IE143/74A patent/IE38792B1/en unknown
- 1974-01-25 ZA ZA00740543A patent/ZA74543B/en unknown
- 1974-01-29 IL IL44109A patent/IL44109A/en unknown
- 1974-02-04 HU HU74LI00000249A patent/HU172393B/en unknown
- 1974-02-07 FR FR7404059A patent/FR2216985B1/fr not_active Expired
- 1974-02-08 DE DE19742406021 patent/DE2406021A1/en not_active Ceased
- 1974-02-11 NL NL7401812A patent/NL7401812A/xx not_active Application Discontinuation
- 1974-02-11 SE SE7401793A patent/SE413836B/en unknown
- 1974-02-12 DD DD176513A patent/DD109509A5/xx unknown
- 1974-02-13 YU YU00367/74A patent/YU36774A/en unknown
- 1974-02-13 JP JP49017489A patent/JPS5029734A/ja active Pending
- 1974-02-13 BE BE6044458A patent/BE810991A/en not_active IP Right Cessation
- 1974-02-13 AT AT113274A patent/AT336794B/en not_active IP Right Cessation
- 1974-02-14 CH CH207474A patent/CH592447A5/xx not_active IP Right Cessation
- 1974-02-14 DK DK78174AA patent/DK137166B/en not_active IP Right Cessation
- 1974-02-14 CS CS741086A patent/CS191908B2/en unknown
- 1974-02-14 ES ES423259A patent/ES423259A1/en not_active Expired
-
1976
- 1976-03-16 ES ES1976219627U patent/ES219627Y/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2406021A1 (en) | 1974-08-29 |
| JPS5029734A (en) | 1975-03-25 |
| DK137166C (en) | 1978-07-03 |
| ES423259A1 (en) | 1976-11-16 |
| DD109509A5 (en) | 1974-11-12 |
| NL7401812A (en) | 1974-08-16 |
| IE38792B1 (en) | 1978-06-07 |
| FR2216985B1 (en) | 1977-06-10 |
| DK137166B (en) | 1978-01-30 |
| ZA74543B (en) | 1975-09-24 |
| SE413836B (en) | 1980-06-30 |
| IL44109A0 (en) | 1974-05-16 |
| ES219627Y (en) | 1977-03-01 |
| AU6506474A (en) | 1975-07-31 |
| CH592447A5 (en) | 1977-10-31 |
| BE810991A (en) | 1974-08-13 |
| FR2216985A1 (en) | 1974-09-06 |
| AT336794B (en) | 1977-05-25 |
| YU36774A (en) | 1983-02-28 |
| CS191908B2 (en) | 1979-07-31 |
| IE38792L (en) | 1974-08-14 |
| GB1455884A (en) | 1976-11-17 |
| ES219627U (en) | 1976-11-01 |
| ATA113274A (en) | 1976-09-15 |
| HU172393B (en) | 1978-08-28 |
| CA1028951A (en) | 1978-04-04 |
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