IL43470A - 2-phenylbicyclo(2,2,2)octane derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

2-phenylbicyclo(2,2,2)octane derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL43470A
IL43470A IL43470A IL4347073A IL43470A IL 43470 A IL43470 A IL 43470A IL 43470 A IL43470 A IL 43470A IL 4347073 A IL4347073 A IL 4347073A IL 43470 A IL43470 A IL 43470A
Authority
IL
Israel
Prior art keywords
compound
methylamine
formula
formula iii
methylamine methylamine
Prior art date
Application number
IL43470A
Other versions
IL43470A0 (en
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of IL43470A0 publication Critical patent/IL43470A0/en
Publication of IL43470A publication Critical patent/IL43470A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/235—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/453—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/457—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (1)

1. CLAIM Compound of the I and acid addition salts wherein n is an integer from 1 to 4 is a trans group of wherein and Rr represent the same or a different substituent selected from or or Compound as claimed in Claim having one or more of the following features n is 1 or is hydrogen and is or or or methoxy or ethoxy in the and are both and are in the and represent is alkyl and methyl or Compound as claimed in Claim having each of the features and as defined in Claim Compound as claimed in Claim having each of the features and as defined in Claim Compound as claimed in Claim having each of the features 2 2 propylamine methylamine methylamine methylamine methylamine 2 methylamine 2 2 methylamine methylamine methylamine methylamine methylamine methylamine methylamine methylamine methylamine methylamine propylamine 2 ethyl Lically acceptable acid addition salts of a compound claimed in of Claims 1 to Process for preparing a compound as claimed in any one of Claims 1 to wherein a known method for the preparation of substituted alkyl amines is Process for preparing a compound of formula I as defined in Claim a compound of the 2 m wherein R is as defined in Claim is 1 or 2 and represents are independently hydrogen or CO or where is in known manner to effect the desired to a Compound of formula Process as claimed in Claim wherein a compound of formula III is to corresponding compound of formula the reduction being out under reductive amination conditions when is or and thereafter where reduction results in the preparation of a primary the latter is alkylated to produce the desired compound of I in which r is Process as in Claiin 35 wherein reductive amination of a compound of formula III in which or is achieved by reducing said compound of formula III to the corresponding conversion f said alcohol to an or aryl sulphonate and reaction of the latter with an amine of formula 1I Process as claimed in Claim wherein amination of a compound of formula III is is achieved by catalytic in the presence amine of Process as claimed in aim wherein conversion of a of in which is or is achieved by ion 6 hydride reducing Process as claimed of a oC Process in to wherein said compound of formula III is reacted in in the reaction medium in which it is Process as claimed in any one of Claims wherein a resultant of I is converted to another compound of formula I by known Process as claimed in Claim wherein a resultant compound of formula I in Avhich or is an amino group is to the corresponding in which or is halogen by diazotization reaction of the diazonium salt so produced with a cuprous to the corresponding compound in which or alkoxy by diazotization and decomposition of the resultant diazonium salt in a to the corresponding compound in which or is or alkylamino by or carbox to the corresponding which is by Process as claimed in any one of Claims to wherein a compound of I is in acid addi salt Process for preparing a compound of I defined in Claim as described in any one of Examples 9 to Compound of formula I as defined in Claim whenever prepared by the process in any one of Claims to composition as an active least one compound as claimed in any one Claims 1 to and or a pharmaceutically acceptable acid addition salt thereof in association with a pharmaceutically carrier Composition in n a dosage unit form c from to of said active Composition as claimed in Glaim Glaim in form adapted parenteral licants insufficientOCRQuality
IL43470A 1972-11-04 1973-10-23 2-phenylbicyclo(2,2,2)octane derivatives,their preparation and pharmaceutical compositions containing them IL43470A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5093172A GB1444717A (en) 1972-11-04 1972-11-04 Bicycloalkyl derivatives

Publications (2)

Publication Number Publication Date
IL43470A0 IL43470A0 (en) 1974-01-14
IL43470A true IL43470A (en) 1976-08-31

Family

ID=10457988

Family Applications (1)

Application Number Title Priority Date Filing Date
IL43470A IL43470A (en) 1972-11-04 1973-10-23 2-phenylbicyclo(2,2,2)octane derivatives,their preparation and pharmaceutical compositions containing them

Country Status (11)

Country Link
JP (2) JPS5747664B2 (en)
BE (1) BE806808A (en)
CH (1) CH588440A5 (en)
DE (1) DE2354931C2 (en)
DK (1) DK142111B (en)
FR (1) FR2205324B1 (en)
GB (1) GB1444717A (en)
IE (1) IE38375B1 (en)
IL (1) IL43470A (en)
NL (1) NL182143C (en)
SE (1) SE419980B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1549174A (en) * 1975-05-08 1979-08-01 Lilly Industries Ltd Amine derivatives
GB1551035A (en) * 1975-07-24 1979-08-22 Lilly Industries Ltd Derivatives of bicyclo (2,2,2)oct-3-ylmethylamine
US4215074A (en) * 1978-07-15 1980-07-29 Lilly Industries Limited Process for preparing cis-bicyclooctylamines
GB2367554A (en) * 2000-10-04 2002-04-10 Lilly Co Eli Pharmacologically active amines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1468808A1 (en) * 1965-04-21 1969-04-17 Du Pont Process for the preparation of substituted phenylbicyclo- (2,2,2) -octanes

Also Published As

Publication number Publication date
GB1444717A (en) 1976-08-04
JPS5936973B2 (en) 1984-09-06
DK142111B (en) 1980-09-01
JPS49132058A (en) 1974-12-18
NL182143B (en) 1987-08-17
DK142111C (en) 1981-02-02
CH588440A5 (en) 1977-05-31
JPS57171941A (en) 1982-10-22
DE2354931A1 (en) 1974-05-09
JPS5747664B2 (en) 1982-10-12
DE2354931C2 (en) 1983-12-08
NL182143C (en) 1988-01-18
SE419980B (en) 1981-09-07
FR2205324A1 (en) 1974-05-31
FR2205324B1 (en) 1976-05-14
NL7315031A (en) 1974-05-07
IE38375L (en) 1974-05-04
BE806808A (en) 1974-04-30
IL43470A0 (en) 1974-01-14
IE38375B1 (en) 1978-03-01

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