IL38972A - Substituted phenyl alkanol derivatives,their preparation and compositions containing them - Google Patents

Substituted phenyl alkanol derivatives,their preparation and compositions containing them

Info

Publication number
IL38972A
IL38972A IL38972A IL3897272A IL38972A IL 38972 A IL38972 A IL 38972A IL 38972 A IL38972 A IL 38972A IL 3897272 A IL3897272 A IL 3897272A IL 38972 A IL38972 A IL 38972A
Authority
IL
Israel
Prior art keywords
compound
formula
group
radical
racemates
Prior art date
Application number
IL38972A
Other versions
IL38972A0 (en
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of IL38972A0 publication Critical patent/IL38972A0/en
Publication of IL38972A publication Critical patent/IL38972A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (1)

1. CLAIM A compound the formula R is an alkoxy group with up to 6 carbon is an group with u 6 or benzoyl is H or is and n 2 or and the acid addition and quaternary ammonium salts is A compound aeeording to claim 1 wherein and R is an group witn up to 6 carbon A compound according to claim 1 which has the formula to as hereinbefore propanol A pharmaceutical composition which comprises at least one compound as claimed in any of claims 1 to together with an physiologically acceptable carrier A composition according to claim 6 dosage unit each dosage unit containing from to 100 of the said A process for preparing a compound as claimed in claim which eithe reacting a compound of wherein X is a radical which can be converted to a group of the formula CHR5 1 2 and R R and R are as defined in claim Λ with an agent or agents which the radical X to the group CHR5 or reacting a compound of the 1 X2 CH2R wherein X is a radical which can converted to a gro of the formula 2 and R R R R and n are as defined in claim 2 with an agent or agents which convert X to the group 1 or converting a compound as claimed in claim to another compound as claimed in claim or converting compounds of formula I into their physiologically acceptable acid addition salts or their quaternary ammonium salts or liberating compounds of formula I from their aci addition or separating obtained racemates or mixtures of racemates into the pure racemates A process for preparing a compound as claimed in claim 1 substantially as herein described in any of the insufficientOCRQuality
IL38972A 1971-03-25 1972-03-13 Substituted phenyl alkanol derivatives,their preparation and compositions containing them IL38972A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712114420 DE2114420A1 (en) 1971-03-25 1971-03-25 Substituted phenylalkanol derivatives and processes for their preparation

Publications (2)

Publication Number Publication Date
IL38972A0 IL38972A0 (en) 1972-05-30
IL38972A true IL38972A (en) 1976-01-30

Family

ID=5802691

Family Applications (1)

Application Number Title Priority Date Filing Date
IL38972A IL38972A (en) 1971-03-25 1972-03-13 Substituted phenyl alkanol derivatives,their preparation and compositions containing them

Country Status (19)

Country Link
US (1) US3770748A (en)
AT (1) AT344169B (en)
AU (1) AU465561B2 (en)
BE (1) BE781212A (en)
BR (1) BR7201760D0 (en)
CA (1) CA980353A (en)
CH (2) CH605739A5 (en)
CS (4) CS163796B2 (en)
DD (1) DD96946A5 (en)
DE (1) DE2114420A1 (en)
DK (1) DK137273C (en)
ES (1) ES401198A1 (en)
FR (1) FR2130659B1 (en)
GB (1) GB1359600A (en)
IL (1) IL38972A (en)
NL (1) NL7203986A (en)
PL (1) PL83328B1 (en)
SE (1) SE374918B (en)
ZA (1) ZA721653B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993763A (en) * 1969-03-18 1976-11-23 Ciba-Geigy Corporation Tertiary aminoacids as anti-inflammatory agents
US3936467A (en) * 1968-03-27 1976-02-03 Ciba-Geigy Corporation Hydroxyalkylenimino-phenyl-acetic acids
US4216326A (en) * 1975-01-20 1980-08-05 Sterling Drug Inc. Intermediates for preparing anti-inflammatory phenyl-lower-alkylamines
US4417052A (en) * 1980-02-15 1983-11-22 Sterling Drug Inc. Phenyl-lower-alkyl piperidines and pyrrolidines
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
JP2008504279A (en) * 2004-06-24 2008-02-14 インサイト・コーポレイション Amide compounds and their use as pharmaceuticals
US7687665B2 (en) * 2004-06-24 2010-03-30 Incyte Corporation 2-methylprop anamides and their use as pharmaceuticals
EA200700117A1 (en) 2004-06-24 2007-06-29 Инсайт Корпорейшн N-SUBSTITUTED PIPERIDINES AND THEIR APPLICATION AS PHARMACEUTICAL PREPARATIONS
AU2005258248A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
MX2007001540A (en) * 2004-08-10 2007-04-23 Incyte Corp Amido compounds and their use as pharmaceuticals.
US20070213311A1 (en) * 2006-03-02 2007-09-13 Yun-Long Li Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
WO2007103719A2 (en) * 2006-03-03 2007-09-13 Incyte Corporation MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
CA2649677A1 (en) * 2006-05-01 2007-11-15 Incyte Corporation Tetrasubstituted ureas as modulators of 11-.beta. hydroxyl steroid dehydrogenase type 1
WO2007137066A2 (en) * 2006-05-17 2007-11-29 Incyte Corporation HETEROCYCLIC INHIBITORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH505090A (en) * 1968-04-29 1971-03-31 Ciba Geigy Ag Substd phenethylalcohols analgesics anti-inflammatory
DE2013376A1 (en) * 1970-03-20 1971-10-07 Merck Patent Gmbh Substituted phenylacetic acids and processes for their preparation

Also Published As

Publication number Publication date
IL38972A0 (en) 1972-05-30
CA980353A (en) 1975-12-23
SE374918B (en) 1975-03-24
CH588460A5 (en) 1977-06-15
BR7201760D0 (en) 1974-01-08
CS163797B2 (en) 1975-11-07
DE2114420A1 (en) 1972-10-05
CH605739A5 (en) 1978-10-13
US3770748A (en) 1973-11-06
GB1359600A (en) 1974-07-10
FR2130659B1 (en) 1975-03-14
ZA721653B (en) 1972-12-27
NL7203986A (en) 1972-09-27
CS168694B2 (en) 1976-06-29
CS163798B2 (en) 1975-11-07
FR2130659A1 (en) 1972-11-03
DD96946A5 (en) 1973-04-12
DK137273B (en) 1978-02-13
PL83328B1 (en) 1975-12-31
AT344169B (en) 1978-07-10
ATA252572A (en) 1977-11-15
BE781212A (en) 1972-09-25
DK137273C (en) 1978-07-17
ES401198A1 (en) 1975-10-01
AU465561B2 (en) 1973-09-27
AU4040472A (en) 1973-09-27
CS163796B2 (en) 1975-11-07

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