IL280316B - Bolaamphiphilic compounds, compositions and uses thereof - Google Patents

Bolaamphiphilic compounds, compositions and uses thereof

Info

Publication number
IL280316B
IL280316B IL280316A IL28031621A IL280316B IL 280316 B IL280316 B IL 280316B IL 280316 A IL280316 A IL 280316A IL 28031621 A IL28031621 A IL 28031621A IL 280316 B IL280316 B IL 280316B
Authority
IL
Israel
Prior art keywords
compositions
bolaamphiphilic compounds
bolaamphiphilic
compounds
Prior art date
Application number
IL280316A
Other languages
Hebrew (he)
Other versions
IL280316A (en
Original Assignee
Lauren Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lauren Sciences Llc filed Critical Lauren Sciences Llc
Publication of IL280316A publication Critical patent/IL280316A/en
Publication of IL280316B publication Critical patent/IL280316B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
IL280316A 2012-09-04 2021-01-20 Bolaamphiphilic compounds, compositions and uses thereof IL280316B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261696789P 2012-09-04 2012-09-04
PCT/US2013/057956 WO2014039501A1 (en) 2012-09-04 2013-09-04 Bolaamphiphilic compounds, compositions and uses thereof

Publications (2)

Publication Number Publication Date
IL280316A IL280316A (en) 2021-03-01
IL280316B true IL280316B (en) 2021-08-31

Family

ID=50237566

Family Applications (3)

Application Number Title Priority Date Filing Date
IL237541A IL237541B (en) 2012-09-04 2015-03-03 Bolaamphiphilic compounds, compositions and uses thereof
IL267888A IL267888B (en) 2012-09-04 2019-07-07 Bolaamphiphilic compounds, compositions and uses thereof
IL280316A IL280316B (en) 2012-09-04 2021-01-20 Bolaamphiphilic compounds, compositions and uses thereof

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL237541A IL237541B (en) 2012-09-04 2015-03-03 Bolaamphiphilic compounds, compositions and uses thereof
IL267888A IL267888B (en) 2012-09-04 2019-07-07 Bolaamphiphilic compounds, compositions and uses thereof

Country Status (5)

Country Link
EP (1) EP2892510A4 (en)
AU (4) AU2013312908A1 (en)
CA (2) CA3233929A1 (en)
IL (3) IL237541B (en)
WO (1) WO2014039501A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3283060A4 (en) * 2015-04-16 2018-12-19 Lauren Sciences LLC Bolaamphiphilic compounds, compositions and uses thereof
CA3150779A1 (en) * 2019-08-12 2021-02-18 Integrated Nanotherapeutics Inc. Lipids for delivery of charged material, formulations thereof and method for making same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002353485B2 (en) * 2001-12-04 2009-01-15 Ben Gurion University Of The Negev Research And Development Authority Amphiphilic compounds and vesicles/liposomes for organ-specific drug targeting
US8377469B2 (en) * 2005-01-03 2013-02-19 Ben-Gurion University Of The Negev Research And Development Authority Nano- and mesosized particles comprising an inorganic core, process and applications thereof
CA2761042C (en) 2009-05-04 2019-11-12 Bengurion University Of The Negev Research And Development Authority Nano-sized particles comprising multi-headed amphiphiles for targeted drug delivery

Also Published As

Publication number Publication date
AU2018203992B2 (en) 2020-02-27
IL237541A0 (en) 2015-04-30
IL280316A (en) 2021-03-01
AU2020203496A1 (en) 2020-06-18
IL237541B (en) 2019-07-31
IL267888A (en) 2019-09-26
EP2892510A4 (en) 2016-06-01
AU2018203992A1 (en) 2018-06-21
WO2014039501A1 (en) 2014-03-13
CA2883784A1 (en) 2014-03-13
EP2892510A1 (en) 2015-07-15
IL267888B (en) 2021-02-28
AU2013312908A1 (en) 2015-03-26
AU2022200494A1 (en) 2022-02-24
AU2020203496B2 (en) 2021-10-28
CA3233929A1 (en) 2014-03-13

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