IL260496B - 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives - Google Patents

3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

Info

Publication number: IL260496B
Authority: IL; Israel
Prior art keywords: diaza; spiro; hetero; oxo; aryl
Prior art date: 2016-01-13

Application number

IL260496A

Other languages

Hebrew (he)

Original Assignee

Gruenenthal Chemie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-01-13

Filing date

2018-07-09

Publication date

2021-09-30

2018-07-09 Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie

2021-09-30 Publication of IL260496B publication Critical patent/IL260496B/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

IL260496A 2016-01-13 2018-07-09 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives IL260496B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP16151012		2016-01-13
PCT/EP2017/025005 WO2017121647A1 (en)	2016-01-13	2017-01-13	3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

Publications (1)

Publication Number	Publication Date
IL260496B true IL260496B (en)	2021-09-30

Family

ID=55129633

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL260496A IL260496B (en)	2016-01-13	2018-07-09	3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
IL285355A IL285355B2 (en)	2016-01-13	2021-08-04	3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL285355A IL285355B2 (en)	2016-01-13	2021-08-04	3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

Country Status (30)

Country	Link
US (7)	US20170197970A1 (en)
EP (2)	EP3722284A1 (en)
JP (2)	JP6893516B2 (en)
KR (2)	KR20180097732A (en)
CN (2)	CN108699006B (en)
AR (2)	AR107434A1 (en)
AU (1)	AU2017206908B2 (en)
BR (1)	BR112018014305B1 (en)
CA (1)	CA3011176C (en)
CL (1)	CL2018001911A1 (en)
CO (1)	CO2018008447A2 (en)
CY (1)	CY1122923T1 (en)
DK (1)	DK3402781T5 (en)
EA (2)	EA037598B1 (en)
EC (1)	ECSP18060834A (en)
ES (1)	ES2807549T3 (en)
HR (1)	HRP20200782T1 (en)
HU (1)	HUE049771T2 (en)
IL (2)	IL260496B (en)
LT (1)	LT3402781T (en)
MX (1)	MX2018008643A (en)
NZ (1)	NZ745185A (en)
PE (1)	PE20221732A1 (en)
PL (1)	PL3402781T3 (en)
PT (1)	PT3402781T (en)
RS (1)	RS60307B1 (en)
SI (1)	SI3402781T1 (en)
TW (1)	TWI635082B (en)
WO (1)	WO2017121647A1 (en)
ZA (1)	ZA201805356B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI640514B (en)	2016-01-13	2018-11-11	歌林達有限公司	3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
RS60855B1 (en)	2016-01-13	2020-10-30	Gruenenthal Gmbh	8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
EA037598B1 (en)	2016-01-13	2021-04-20	Грюненталь Гмбх	3-((hetero)aryl)-8-amino-2-oxo-1,3-diaza-spiro[4.5]decane derivatives
KR20180098369A (en) *	2016-01-13	2018-09-03	그뤼넨탈 게엠베하	3 - ((hetero-) aryl) -alkyl-8-amino-2-oxo-1,3-diaza-spiro- [4.5]
CN110862395B (en) *	2019-11-13	2020-09-29	株洲千金药业股份有限公司	Preparation method of raw material compound for preparing tadalafil important impurities

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DE102005044813A1 (en)	2005-05-19	2007-10-04	Grünenthal GmbH	Substituted spiro compounds and their use for the preparation of medicaments
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DE102005030051A1 (en)	2005-06-27	2006-12-28	Grünenthal GmbH	New substituted 1-oxo-3,8-diazospiro(4.5)-decan-2-one compounds are 5-hydroxy tryptamine uptake receptor inhibitors, useful to treat and/or prevent e.g. pain, migraine, chronic paroxysomal hemicrania, depression and asthma
DE102006019597A1 (en)	2006-04-27	2007-10-31	Grünenthal GmbH	New spirocyclic cyclohexane derivatives useful for treating pain, depression, urinary incontinence, diarrhea, pruritis, alcohol and drug abuse, medicament dependence, lack of drive and/or anxiety
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WO2015192039A1 (en)	2014-06-13	2015-12-17	Purdue Pharma L.P.	Heterocyclic morphinan derivatives and use thereof
LT3402811T (en)	2016-01-13	2022-06-10	Novo Nordisk A/S	Egf(a) analogues with fatty acid substituents
EA037598B1 (en)	2016-01-13	2021-04-20	Грюненталь Гмбх	3-((hetero)aryl)-8-amino-2-oxo-1,3-diaza-spiro[4.5]decane derivatives
RS60855B1 (en)	2016-01-13	2020-10-30	Gruenenthal Gmbh	8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
WO2017121646A1 (en)	2016-01-13	2017-07-20	Grünenthal GmbH	3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
TWI640514B (en)	2016-01-13	2018-11-11	歌林達有限公司	3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
AR107354A1 (en)	2016-01-13	2018-04-18	Bristol Myers Squibb Co	SPIROHEPTAN SALICILAMIDS AND RELATED COMPOUNDS AS ROCK INHIBITORS
KR20180098369A (en) *	2016-01-13	2018-09-03	그뤼넨탈 게엠베하	3 - ((hetero-) aryl) -alkyl-8-amino-2-oxo-1,3-diaza-spiro- [4.5]

2017
- 2017-01-13 EA EA201891611A patent/EA037598B1/en unknown
- 2017-01-13 ES ES17700389T patent/ES2807549T3/en active Active
- 2017-01-13 CN CN201780006506.5A patent/CN108699006B/en active Active
- 2017-01-13 SI SI201730263T patent/SI3402781T1/en unknown
- 2017-01-13 NZ NZ745185A patent/NZ745185A/en unknown
- 2017-01-13 JP JP2018536436A patent/JP6893516B2/en active Active
- 2017-01-13 WO PCT/EP2017/025005 patent/WO2017121647A1/en active Application Filing
- 2017-01-13 KR KR1020187021552A patent/KR20180097732A/en not_active Application Discontinuation
- 2017-01-13 EA EA202190281A patent/EA202190281A1/en unknown
- 2017-01-13 CN CN202111487304.1A patent/CN114149413A/en active Pending
- 2017-01-13 AU AU2017206908A patent/AU2017206908B2/en active Active
- 2017-01-13 AR ARP170100091A patent/AR107434A1/en unknown
- 2017-01-13 PT PT177003894T patent/PT3402781T/en unknown
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Publication number	Publication date
JP6893516B2 (en)	2021-06-23
CO2018008447A2 (en)	2018-08-31
CN114149413A (en)	2022-03-08
US20230303573A1 (en)	2023-09-28
RS60307B1 (en)	2020-07-31
US20180201616A1 (en)	2018-07-19
IL285355B2 (en)	2023-05-01
JP2021091716A (en)	2021-06-17
AU2017206908B2 (en)	2020-07-09
IL285355B1 (en)	2023-01-01
HUE049771T2 (en)	2020-10-28
CA3011176C (en)	2023-09-19
ZA201805356B (en)	2021-04-28
DK3402781T3 (en)	2020-05-18
EA037598B1 (en)	2021-04-20
WO2017121647A1 (en)	2017-07-20
JP2019501937A (en)	2019-01-24
CL2018001911A1 (en)	2018-10-19
AU2017206908A1 (en)	2018-08-30
EP3722284A1 (en)	2020-10-14
ECSP18060834A (en)	2018-08-31
CN108699006A (en)	2018-10-23
BR112018014305A2 (en)	2018-12-11
ES2807549T3 (en)	2021-02-23
MX2018008643A (en)	2018-11-19
NZ745185A (en)	2024-03-22
TWI635082B (en)	2018-09-11
PL3402781T3 (en)	2020-09-21
EP3402781B1 (en)	2020-03-04
AR107434A1 (en)	2018-05-02
US20170197970A1 (en)	2017-07-13
EA202190281A1 (en)	2021-09-01
SI3402781T1 (en)	2020-10-30
CY1122923T1 (en)	2021-10-29
US20210032256A1 (en)	2021-02-04
US20210188860A1 (en)	2021-06-24
AR124672A2 (en)	2023-04-19
EA201891611A1 (en)	2019-01-31
CN108699006B (en)	2021-11-05
JP7148660B2 (en)	2022-10-05
PE20221732A1 (en)	2022-11-07
US20190375754A1 (en)	2019-12-12
BR112018014305B1 (en)	2023-10-17
EP3402781A1 (en)	2018-11-21
TW201730156A (en)	2017-09-01
KR20180097732A (en)	2018-08-31
HRP20200782T1 (en)	2020-08-21
US10807988B2 (en)	2020-10-20
IL285355A (en)	2021-09-30
US20190106429A1 (en)	2019-04-11
DK3402781T5 (en)	2020-06-02
PT3402781T (en)	2020-07-07
LT3402781T (en)	2020-06-10
KR20240070681A (en)	2024-05-21
CA3011176A1 (en)	2017-07-20

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