IL250799A0 - Chimeras of soluble dr3 and pro-tace domain and use thereof - Google Patents

Chimeras of soluble dr3 and pro-tace domain and use thereof

Info

Publication number
IL250799A0
IL250799A0 IL250799A IL25079917A IL250799A0 IL 250799 A0 IL250799 A0 IL 250799A0 IL 250799 A IL250799 A IL 250799A IL 25079917 A IL25079917 A IL 25079917A IL 250799 A0 IL250799 A0 IL 250799A0
Authority
IL
Israel
Prior art keywords
tace
chimeras
pro
soluble
domain
Prior art date
Application number
IL250799A
Other languages
Hebrew (he)
Inventor
Amir Aharoni
Itay Levin
WEIZMAN Tomer
Sagi Irit
Original Assignee
The Nat Inst For Biotechnology In The Negev Ltd
Amir Aharoni
Itay Levin
WEIZMAN Tomer
Sagi Irit
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Nat Inst For Biotechnology In The Negev Ltd, Amir Aharoni, Itay Levin, WEIZMAN Tomer, Sagi Irit, Yeda Res & Dev filed Critical The Nat Inst For Biotechnology In The Negev Ltd
Priority to IL250799A priority Critical patent/IL250799A0/en
Publication of IL250799A0 publication Critical patent/IL250799A0/en
Priority to PCT/IL2018/050214 priority patent/WO2018154584A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
IL250799A 2017-02-26 2017-02-26 Chimeras of soluble dr3 and pro-tace domain and use thereof IL250799A0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL250799A IL250799A0 (en) 2017-02-26 2017-02-26 Chimeras of soluble dr3 and pro-tace domain and use thereof
PCT/IL2018/050214 WO2018154584A1 (en) 2017-02-26 2018-02-25 Chimeras of soluble dr3 and pro-tace domain and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL250799A IL250799A0 (en) 2017-02-26 2017-02-26 Chimeras of soluble dr3 and pro-tace domain and use thereof

Publications (1)

Publication Number Publication Date
IL250799A0 true IL250799A0 (en) 2017-04-30

Family

ID=58669516

Family Applications (1)

Application Number Title Priority Date Filing Date
IL250799A IL250799A0 (en) 2017-02-26 2017-02-26 Chimeras of soluble dr3 and pro-tace domain and use thereof

Country Status (2)

Country Link
IL (1) IL250799A0 (en)
WO (1) WO2018154584A1 (en)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5541110A (en) 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
ES2627816T3 (en) 2012-05-09 2017-07-31 Yeda Research And Development Co. Ltd. Variants of the pro-domain of tace as a TNF-a inhibitor and its medical use
EP3137495A4 (en) 2014-04-28 2017-11-15 The National Institute for Biotechnology in the Negev, Ltd. Variants of dr3 and use thereof

Also Published As

Publication number Publication date
WO2018154584A1 (en) 2018-08-30

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