IL247832B - 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation - Google Patents
2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparationInfo
- Publication number
- IL247832B IL247832B IL24783216A IL24783216A IL247832B IL 247832 B IL247832 B IL 247832B IL 24783216 A IL24783216 A IL 24783216A IL 24783216 A IL24783216 A IL 24783216A IL 247832 B IL247832 B IL 247832B
- Authority
- IL
- Israel
- Prior art keywords
- ols
- tetrazol
- difluorophenyl
- propan
- difluoro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461955680P | 2014-03-19 | 2014-03-19 | |
| PCT/US2015/021527 WO2015143192A1 (en) | 2014-03-19 | 2015-03-19 | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL247832A0 IL247832A0 (en) | 2016-11-30 |
| IL247832B true IL247832B (en) | 2019-10-31 |
Family
ID=54145334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL24783216A IL247832B (en) | 2014-03-19 | 2016-09-15 | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9988365B2 (en) |
| EP (1) | EP3119756B9 (en) |
| JP (1) | JP6633539B2 (en) |
| KR (1) | KR102441243B1 (en) |
| CN (2) | CN106132947B (en) |
| BR (1) | BR112016021260B1 (en) |
| CA (1) | CA2942982C (en) |
| IL (1) | IL247832B (en) |
| MX (2) | MX2016012060A (en) |
| WO (1) | WO2015143192A1 (en) |
| ZA (1) | ZA201606386B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10017494B2 (en) | 2014-03-19 | 2018-07-10 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| EP3119771B1 (en) | 2014-03-19 | 2020-05-06 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942968C (en) | 2014-03-19 | 2022-03-15 | William J. Hoekstra | Antifungal compound process |
| KR102441242B1 (en) | 2014-03-19 | 2022-09-07 | 브이피에스-3, 엘엘씨 | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
| CA2942932A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942976C (en) | 2014-03-19 | 2022-05-10 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| KR102441243B1 (en) | 2014-03-19 | 2022-09-07 | 브이피에스-3, 엘엘씨 | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
| WO2015143180A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| AU2015231220B2 (en) | 2014-03-19 | 2019-04-04 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Antifungal compound process |
| EA036098B1 (en) | 2015-09-18 | 2020-09-28 | ВиПиЭс-3, ИНК. | Process for preparing antifungal compounds |
| AR106728A1 (en) * | 2015-11-17 | 2018-02-14 | Viamet Pharmaceuticals Inc | 4 - ((6- (2- (2,4DIFLUOROFENIL) -1,1-DIFLUORO-2-HIDROXI-3- (1H-1,2,4-TRIAZOL-1-IL) PROPIL) PIRIDIN-3-IL) OXI) BENZONITRILE AND PROCESS FOR PREPARATION |
| AR106729A1 (en) * | 2015-11-17 | 2018-02-14 | Viamet Pharmaceuticals Inc | 4 - ((6- (2- (2,4-DIFLUOROFENIL) -1,1-DIFLUORO-2-OXOETIL) PIRIDIN-3-IL) OXI) BENZONITRILE AND PROCESS FOR PREPARATION |
| EP3710432A1 (en) | 2017-11-13 | 2020-09-23 | Bayer Aktiengesellschaft | Tetrazolylpropyl derivatives and their use as fungicides |
| CN114573557B (en) * | 2022-03-28 | 2024-03-08 | 浙江天宇药业股份有限公司 | Preparation method of octreonazole |
| CN114573503B (en) * | 2022-03-28 | 2024-04-09 | 浙江天宇药业股份有限公司 | Method for preparing octreotide intermediate |
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| CN1054853C (en) | 1995-01-11 | 2000-07-26 | 上海三维制药公司 | Prepn of 1-[2-(2,4-difluorophenyl)2,3-epoxypropyl]-1H-1,2,4-triazole as intermediate of fluconazole and its methyl sulphonate |
| US6509471B2 (en) * | 1998-07-21 | 2003-01-21 | Syngenta Participations Ag | 3-substituted pyridine compounds and related synthesis |
| CN1326850C (en) | 1998-12-18 | 2007-07-18 | 先灵公司 | Tricyclic farnesyl protein transferase inhibitors |
| JP2000344744A (en) | 1999-06-04 | 2000-12-12 | Ss Pharmaceut Co Ltd | Derivative of acetophenone and its production |
| US6809105B2 (en) * | 2000-04-27 | 2004-10-26 | Abbott Laboratories | Diazabicyclic central nervous system active agents |
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| MX2012008346A (en) | 2010-01-25 | 2012-11-12 | Chdi Foundation Inc | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof. |
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| WO2015143137A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942968C (en) | 2014-03-19 | 2022-03-15 | William J. Hoekstra | Antifungal compound process |
| KR102441243B1 (en) | 2014-03-19 | 2022-09-07 | 브이피에스-3, 엘엘씨 | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
| WO2015143180A1 (en) | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942976C (en) | 2014-03-19 | 2022-05-10 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| CA2942932A1 (en) * | 2014-03-19 | 2015-09-24 | Viamet Pharmaceuticals, Inc. | Antifungal compound process |
| US10017494B2 (en) | 2014-03-19 | 2018-07-10 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| AU2015231220B2 (en) | 2014-03-19 | 2019-04-04 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Antifungal compound process |
| EP3119771B1 (en) * | 2014-03-19 | 2020-05-06 | Mycovia Pharmaceuticals, Inc. | Antifungal compound process |
| KR102441242B1 (en) | 2014-03-19 | 2022-09-07 | 브이피에스-3, 엘엘씨 | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation |
| ES2926063T3 (en) * | 2015-03-19 | 2022-10-21 | Mycovia Pharmaceuticals Inc | Antifungal compounds and manufacturing procedures |
| KR20180000731A (en) * | 2015-05-18 | 2018-01-03 | 비아멧 파마슈티컬즈, 인코포레이티드 | Antifungal compound |
| EA036098B1 (en) * | 2015-09-18 | 2020-09-28 | ВиПиЭс-3, ИНК. | Process for preparing antifungal compounds |
| AR106728A1 (en) | 2015-11-17 | 2018-02-14 | Viamet Pharmaceuticals Inc | 4 - ((6- (2- (2,4DIFLUOROFENIL) -1,1-DIFLUORO-2-HIDROXI-3- (1H-1,2,4-TRIAZOL-1-IL) PROPIL) PIRIDIN-3-IL) OXI) BENZONITRILE AND PROCESS FOR PREPARATION |
| JP2018533635A (en) | 2015-11-17 | 2018-11-15 | ダウ アグロサイエンシィズ エルエルシー | 4-((6- (2- (2,4-Difluorophenyl) -1,1-difluoro-2-hydroxy-3- (1H-1,2,4-triazol-1-yl) propyl) pyridine -3-yl) oxy) benzonitrile and method of preparation |
| AR106731A1 (en) | 2015-11-17 | 2018-02-14 | Viamet Pharmaceuticals Inc | 4 - ((6- (2- (2,4-DIFLUOROFENIL) -1,1-DIFLUORO-2-HIDROXI-3- (1H-1,2,4-TRIAZOL-1-IL) PROPIL) PIRIDIN-3- IL) OXI) BENZONITRILE AND PROCESS FOR PREPARATION |
| AR106729A1 (en) | 2015-11-17 | 2018-02-14 | Viamet Pharmaceuticals Inc | 4 - ((6- (2- (2,4-DIFLUOROFENIL) -1,1-DIFLUORO-2-OXOETIL) PIRIDIN-3-IL) OXI) BENZONITRILE AND PROCESS FOR PREPARATION |
| US10464922B2 (en) | 2015-12-30 | 2019-11-05 | Nqp 1598, Ltd. | Metalloenzyme inhibitor compounds |
-
2015
- 2015-03-19 KR KR1020167025151A patent/KR102441243B1/en active IP Right Grant
- 2015-03-19 BR BR112016021260-6A patent/BR112016021260B1/en active IP Right Grant
- 2015-03-19 CN CN201580014266.4A patent/CN106132947B/en active Active
- 2015-03-19 WO PCT/US2015/021527 patent/WO2015143192A1/en active Application Filing
- 2015-03-19 CA CA2942982A patent/CA2942982C/en active Active
- 2015-03-19 MX MX2016012060A patent/MX2016012060A/en active IP Right Grant
- 2015-03-19 JP JP2016557564A patent/JP6633539B2/en active Active
- 2015-03-19 EP EP15765402.1A patent/EP3119756B9/en active Active
- 2015-03-19 US US15/126,353 patent/US9988365B2/en active Active
- 2015-03-19 CN CN201811099901.5A patent/CN109678791B/en active Active
-
2016
- 2016-09-15 MX MX2019011789A patent/MX2019011789A/en unknown
- 2016-09-15 ZA ZA2016/06386A patent/ZA201606386B/en unknown
- 2016-09-15 IL IL24783216A patent/IL247832B/en active IP Right Grant
-
2018
- 2018-02-01 US US15/886,526 patent/US10301283B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10301283B2 (en) | 2019-05-28 |
| WO2015143192A1 (en) | 2015-09-24 |
| KR102441243B1 (en) | 2022-09-07 |
| CN106132947A (en) | 2016-11-16 |
| JP6633539B2 (en) | 2020-01-22 |
| EP3119756A4 (en) | 2017-09-20 |
| EP3119756B1 (en) | 2021-04-21 |
| MX2019011789A (en) | 2019-11-18 |
| US9988365B2 (en) | 2018-06-05 |
| CN106132947B (en) | 2019-08-09 |
| CN109678791A (en) | 2019-04-26 |
| IL247832A0 (en) | 2016-11-30 |
| JP2017507982A (en) | 2017-03-23 |
| US20170158667A1 (en) | 2017-06-08 |
| CA2942982A1 (en) | 2015-09-24 |
| KR20160133446A (en) | 2016-11-22 |
| EP3119756A1 (en) | 2017-01-25 |
| ZA201606386B (en) | 2020-01-29 |
| CN109678791B (en) | 2022-07-01 |
| BR112016021260B1 (en) | 2020-05-26 |
| US20180155324A1 (en) | 2018-06-07 |
| MX2016012060A (en) | 2017-01-19 |
| CA2942982C (en) | 2023-09-19 |
| EP3119756B9 (en) | 2021-08-25 |
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