IL243729B - Novel 4h-chromen-4-one compounds as modulators of protein kinases - Google Patents

Novel 4h-chromen-4-one compounds as modulators of protein kinases

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Publication number
IL243729B
IL243729B IL243729A IL24372916A IL243729B IL 243729 B IL243729 B IL 243729B IL 243729 A IL243729 A IL 243729A IL 24372916 A IL24372916 A IL 24372916A IL 243729 B IL243729 B IL 243729B
Authority
IL
Israel
Prior art keywords
chromen
modulators
novel
compounds
protein kinases
Prior art date
Application number
IL243729A
Other languages
Hebrew (he)
Other versions
IL243729A0 (en
Inventor
Muthuppalaniappan Meyyappan
Viswanadha Srikant
Babu Govindarajulu
Kumar V S Vakkalanka Swaroop
Kashinath Bhavar Prashnant
Nagarathnam Dhanapalan
Original Assignee
Rhizen Pharmaceuticals S A
Muthuppalaniappan Meyyappan
Viswanadha Srikant
Babu Govindarajulu
Kumar V S Vakkalanka Swaroop
Kashinath Bhavar Prashnant
Nagarathnam Dhanapalan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/036594 external-priority patent/WO2012151525A1/en
Application filed by Rhizen Pharmaceuticals S A, Muthuppalaniappan Meyyappan, Viswanadha Srikant, Babu Govindarajulu, Kumar V S Vakkalanka Swaroop, Kashinath Bhavar Prashnant, Nagarathnam Dhanapalan filed Critical Rhizen Pharmaceuticals S A
Publication of IL243729A0 publication Critical patent/IL243729A0/en
Publication of IL243729B publication Critical patent/IL243729B/en

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    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
    • C—CHEMISTRY; METALLURGY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
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    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
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    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
IL243729A 2011-05-04 2016-01-21 Novel 4h-chromen-4-one compounds as modulators of protein kinases IL243729B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1542CH2011 2011-05-04
PCT/US2012/036594 WO2012151525A1 (en) 2011-05-04 2012-05-04 Novel compounds as modulators of protein kinases

Publications (2)

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IL243729A0 IL243729A0 (en) 2016-04-21
IL243729B true IL243729B (en) 2020-09-30

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Family Applications (3)

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IL229235A IL229235B (en) 2011-05-04 2013-11-04 4h-chromen-4-one derivatives as modulators of protein kinases
IL243729A IL243729B (en) 2011-05-04 2016-01-21 Novel 4h-chromen-4-one compounds as modulators of protein kinases
IL259166A IL259166A (en) 2011-05-04 2018-05-06 Novel 4h chromen 4 one compounds as modulators of protein kinases

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IL229235A IL229235B (en) 2011-05-04 2013-11-04 4h-chromen-4-one derivatives as modulators of protein kinases

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IL259166A IL259166A (en) 2011-05-04 2018-05-06 Novel 4h chromen 4 one compounds as modulators of protein kinases

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IL259166A (en) 2018-06-28
IL243729A0 (en) 2016-04-21
IL229235B (en) 2018-05-31
IL229235A0 (en) 2014-01-30

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