IL237985B - Humanized immunobinder capable of binding to an antigen of interest - Google Patents

Humanized immunobinder capable of binding to an antigen of interest

Info

Publication number
IL237985B
IL237985B IL237985A IL23798515A IL237985B IL 237985 B IL237985 B IL 237985B IL 237985 A IL237985 A IL 237985A IL 23798515 A IL23798515 A IL 23798515A IL 237985 B IL237985 B IL 237985B
Authority
IL
Israel
Prior art keywords
antigen
interest
binding
humanized immunobinder
humanized
Prior art date
Application number
IL237985A
Other languages
Hebrew (he)
Original Assignee
Esbatech Alcon Biomed Res Unit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CH2009/000222 external-priority patent/WO2009155726A2/en
Priority claimed from PCT/CH2010/000044 external-priority patent/WO2010096941A1/en
Application filed by Esbatech Alcon Biomed Res Unit filed Critical Esbatech Alcon Biomed Res Unit
Publication of IL237985B publication Critical patent/IL237985B/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/5052—Cells of the immune system involving B-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL237985A 2009-02-24 2015-03-26 Humanized immunobinder capable of binding to an antigen of interest IL237985B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15504109P 2009-02-24 2009-02-24
US15510509P 2009-02-24 2009-02-24
CH8322009 2009-06-02
PCT/CH2009/000222 WO2009155726A2 (en) 2008-06-25 2009-06-25 Humanization of rabbit antibodies using a universal antibody framework
PCT/CH2010/000044 WO2010096941A1 (en) 2009-02-24 2010-02-22 Methods for identifying immunobinders of cell-surface antigens

Publications (1)

Publication Number Publication Date
IL237985B true IL237985B (en) 2018-12-31

Family

ID=48917567

Family Applications (4)

Application Number Title Priority Date Filing Date
IL226956A IL226956A (en) 2009-02-24 2013-06-13 Methods for identifying an immunobinder that specifically binds to an antigen of interest
IL226955A IL226955A (en) 2009-02-24 2013-06-13 Methods for identifying a b-cell clone that specifically binds to an antigen of interest, methods for producing an immunobinder and immunobinders produced by said methods
IL237985A IL237985B (en) 2009-02-24 2015-03-26 Humanized immunobinder capable of binding to an antigen of interest
IL26315818A IL263158B (en) 2009-02-24 2018-11-20 Methods for identifying immunobinders of cell-surface antigens

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL226956A IL226956A (en) 2009-02-24 2013-06-13 Methods for identifying an immunobinder that specifically binds to an antigen of interest
IL226955A IL226955A (en) 2009-02-24 2013-06-13 Methods for identifying a b-cell clone that specifically binds to an antigen of interest, methods for producing an immunobinder and immunobinders produced by said methods

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL26315818A IL263158B (en) 2009-02-24 2018-11-20 Methods for identifying immunobinders of cell-surface antigens

Country Status (12)

Country Link
JP (3) JP6161655B2 (en)
KR (4) KR20180005752A (en)
CN (1) CN105116138A (en)
BR (1) BRPI1005398A2 (en)
CL (1) CL2011001453A1 (en)
ES (1) ES2618181T3 (en)
IL (4) IL226956A (en)
MX (1) MX352922B (en)
PH (1) PH12014502468A1 (en)
RU (2) RU2577965C2 (en)
SG (3) SG10201408247SA (en)
ZA (1) ZA201103125B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110016462B (en) * 2019-02-20 2020-04-24 优睿赛思(武汉)生物科技有限公司 Method for efficiently separating single antigen-specific B lymphocytes from spleen cells

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63253098A (en) * 1987-04-10 1988-10-20 Ube Ind Ltd Monoclonal antibody against human antibody, its production and use thereof
IL91948A (en) 1988-10-26 1994-05-30 Immunomedics Removal of immunoreactive components from a sample
US5417972A (en) * 1993-08-02 1995-05-23 The Board Of Trustees Of The Leland Stanford Junior University Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM
KR0119909B1 (en) * 1993-10-05 1997-10-20 김은영 Immunology measurement using flow cytometer
EP1978033A3 (en) * 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
ATE253593T1 (en) * 1996-07-16 2003-11-15 Plueckthun Andreas Prof Dr IMMUNOGLOBULIN SUPERFAMILY DOMAINS AND FRAGMENTS WITH INCREASED SOLUBILITY
ES2399617T3 (en) * 2002-05-22 2013-04-02 Esbatech - A Novartis Company Llc Immunoglobulin framework regions demonstrating enhanced stability in the intracellular environment and their identification methods
CN1396182A (en) * 2002-07-31 2003-02-12 陕西超英生物医学研究开发有限公司 Human monoclonal antibody of human endophloeodal growth factor receptor 2 protein and its preparing process
JP2005535341A (en) * 2002-08-15 2005-11-24 エピトミスク インコーポレーティッド Humanized rabbit antibody
WO2004044584A1 (en) * 2002-11-13 2004-05-27 Micromet Ag Method for identifying antigen specific b cells
JP4336812B2 (en) * 2003-03-07 2009-09-30 博夫 岩田 Analytical method for rapid identification of surface antigens expressed in cells
US20070087331A1 (en) * 2003-05-15 2007-04-19 Cytos Biotechnology Ag Selection of b cells with specificity if interest: method of preparation and use
WO2005016950A1 (en) * 2003-08-07 2005-02-24 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies
CA2655511C (en) * 2005-07-01 2017-03-21 John Schrader Methods of isolating cells and generating monoclonal antibodies
US20070134249A1 (en) * 2005-12-08 2007-06-14 Genitope Corporation Combination therapy and antibody panels
CA2635849C (en) * 2005-12-28 2017-05-09 Asubio Pharma Co., Ltd. An antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved
ES2398076T3 (en) * 2006-06-02 2013-03-13 Regeneron Pharmaceuticals, Inc. High affinity antibodies against the human IL-6 receptor
WO2008004834A1 (en) * 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor

Also Published As

Publication number Publication date
IL263158B (en) 2019-10-31
KR20180005752A (en) 2018-01-16
SG10201708233VA (en) 2017-11-29
KR20190020202A (en) 2019-02-27
IL226955A0 (en) 2013-07-31
MX352922B (en) 2017-12-14
CN105116138A (en) 2015-12-02
RU2577965C2 (en) 2016-03-20
SG2014014864A (en) 2014-09-26
RU2011124039A (en) 2012-12-20
RU2017135831A3 (en) 2019-04-09
KR101817279B1 (en) 2018-01-10
CL2011001453A1 (en) 2012-02-24
JP2015146825A (en) 2015-08-20
IL263158A (en) 2018-12-31
PH12014502468B1 (en) 2016-01-18
SG10201408247SA (en) 2015-02-27
KR101689791B1 (en) 2016-12-26
KR20160022397A (en) 2016-02-29
ZA201103125B (en) 2012-08-29
JP6604989B2 (en) 2019-11-13
IL226956A (en) 2015-04-30
JP2018196395A (en) 2018-12-13
PH12014502468A1 (en) 2016-01-18
BRPI1005398A2 (en) 2019-03-26
KR102059866B1 (en) 2019-12-27
IL226955A (en) 2015-04-30
ES2618181T3 (en) 2017-06-21
JP2017192384A (en) 2017-10-26
IL226956A0 (en) 2013-07-31
RU2017135831A (en) 2019-04-09
KR20160150642A (en) 2016-12-30
JP6161655B2 (en) 2017-07-12

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