IL197958A0 - Bicyclic triazoles as protein kinase modulators - Google Patents

Bicyclic triazoles as protein kinase modulators

Info

Publication number
IL197958A0
IL197958A0 IL197958A IL19795809A IL197958A0 IL 197958 A0 IL197958 A0 IL 197958A0 IL 197958 A IL197958 A IL 197958A IL 19795809 A IL19795809 A IL 19795809A IL 197958 A0 IL197958 A0 IL 197958A0
Authority
IL
Israel
Prior art keywords
protein kinase
kinase modulators
bicyclic triazoles
triazoles
bicyclic
Prior art date
Application number
IL197958A
Original Assignee
Sgx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sgx Pharmaceuticals Inc filed Critical Sgx Pharmaceuticals Inc
Publication of IL197958A0 publication Critical patent/IL197958A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
IL197958A 2006-10-23 2009-04-05 Bicyclic triazoles as protein kinase modulators IL197958A0 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86255206P 2006-10-23 2006-10-23
US87030906P 2006-12-15 2006-12-15
US91376607P 2007-04-24 2007-04-24
US95284007P 2007-07-30 2007-07-30
PCT/US2007/081841 WO2008051808A2 (en) 2006-10-23 2007-10-18 Bicyclic triazoles as protein kinase modulators

Publications (1)

Publication Number Publication Date
IL197958A0 true IL197958A0 (en) 2009-12-24

Family

ID=38956385

Family Applications (1)

Application Number Title Priority Date Filing Date
IL197958A IL197958A0 (en) 2006-10-23 2009-04-05 Bicyclic triazoles as protein kinase modulators

Country Status (25)

Country Link
US (1) US8507489B2 (en)
EP (1) EP2084162B1 (en)
JP (1) JP5378222B2 (en)
KR (1) KR20090071612A (en)
AR (1) AR063520A1 (en)
AU (1) AU2007309149C1 (en)
BR (1) BRPI0717320A2 (en)
CA (1) CA2667428A1 (en)
CO (1) CO6190620A2 (en)
CR (1) CR10803A (en)
DK (1) DK2084162T3 (en)
EA (1) EA200970403A1 (en)
ES (1) ES2393130T3 (en)
IL (1) IL197958A0 (en)
MA (1) MA30871B1 (en)
MX (1) MX2009004059A (en)
NO (1) NO20091618L (en)
NZ (1) NZ575336A (en)
PE (1) PE20080893A1 (en)
PL (1) PL2084162T3 (en)
PT (1) PT2084162E (en)
SV (1) SV2009003235A (en)
TN (1) TN2009000142A1 (en)
TW (1) TW200835492A (en)
WO (1) WO2008051808A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8792501A1 (en) * 2007-08-09 2009-04-23 Sanofi Aventis NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS.
TWI365185B (en) 2008-07-24 2012-06-01 Lilly Co Eli Amidophenoxyindazoles useful as inhibitors of c-met
UY32049A (en) 2008-08-14 2010-03-26 Takeda Pharmaceutical CMET INHIBITORS
EP2165710A1 (en) 2008-09-19 2010-03-24 Institut Curie Tyrosine kinase receptor Tyro3 as a therapeutic target in the treatment of a bladder tumor
JP2012509342A (en) 2008-11-20 2012-04-19 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド Substituted pyrrolo [2,3-B] -pyridine and -pyrazine
FR2941951B1 (en) * 2009-02-06 2011-04-01 Sanofi Aventis 6- (6-NH-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET.
FR2941952B1 (en) * 2009-02-06 2011-04-01 Sanofi Aventis 6- (6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) DERIVATIVES 5-FLUORO-BENZOTHIAZOLES AND 5-FLUORO-BENZIMIDAZOLES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET.
FR2941950B1 (en) * 2009-02-06 2011-04-01 Sanofi Aventis 6- (6-O-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET.
FR2941949B1 (en) * 2009-02-06 2011-04-01 Sanofi Aventis DERIVATIVES OF 6- (6-O-CYCLOALKYL OR 6-NH-CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET.
MX2012001838A (en) 2009-08-12 2012-02-29 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation.
EP2467383A1 (en) 2009-08-20 2012-06-27 Novartis AG Heterocyclic oxime compounds
JP5337313B2 (en) 2009-12-31 2013-11-06 ハッチソン・メディファーマ・リミテッド Specific triazolopyridines and triazolopyrazines, compositions thereof and methods of their use
AR081039A1 (en) 2010-05-14 2012-05-30 Osi Pharmaceuticals Llc QUINASA FUSIONED BICYCLE INHIBITORS
WO2011143646A1 (en) 2010-05-14 2011-11-17 OSI Pharmaceuticals, LLC Fused bicyclic kinase inhibitors
AR085183A1 (en) 2010-07-30 2013-09-18 Lilly Co Eli COMPOUND 6- (1-METHYL-1H-PIRAZOL-4-IL) -3- (2-METHYL-2H-INDAZOL-5-ILTIO) - [1,2,4] TRIAZOL [4,3-B] PIRIDAZINE, PHARMACEUTICAL COMPOSITION THAT UNDERSTAND AND USE IT TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT CANCER
UY33549A (en) * 2010-08-10 2012-01-31 Glaxo Group Ltd QUINOLIL AMINAS AS INHIBITING AGENTS OF KINASES
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
CN102532141A (en) 2010-12-08 2012-07-04 中国科学院上海药物研究所 (1,2,4)-triazolo-(4,3-b) (1,2,4)-triazine compounds, as well as preparation method and use thereof
CA2824047C (en) 2011-01-11 2019-06-18 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
US20130324526A1 (en) * 2011-02-10 2013-12-05 Novartis Ag [1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
CN103459396B (en) * 2011-02-10 2015-08-19 诺瓦提斯公司 As [1,2,4] triazolo [4,3-b] pyridazine compound of c-Met tyrosine kinase inhibitor
JP2014513724A (en) 2011-05-16 2014-06-05 オーエスアイ・ファーマシューティカルズ，エルエルシー Fusion bicyclic kinase inhibitor
EP2755976B1 (en) * 2011-09-15 2018-07-18 Novartis AG 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors
CN103958509B (en) * 2011-09-15 2015-12-23 诺华股份有限公司 As 3-(quinoline-6-base sulfo-)-[1,2,4] triazolo [4,3-A] pyridine compounds that the 6-of tyrosine kinase inhibitor replaces
WO2013149581A1 (en) 2012-04-03 2013-10-10 Novartis Ag Combination products with tyrosine kinase inhibitors and their use
AU2013243737B2 (en) 2012-04-03 2016-06-30 Novartis Ag Tyrosine kinase inhibitor combinations and their use
CN103122000B (en) * 2012-09-03 2013-12-25 中美冠科生物技术（太仓）有限公司 High-selectivity c-Met kinase inhibitor used as antitumor drug
WO2014089904A1 (en) 2012-12-10 2014-06-19 Abbvie Inc. Triazinone compounds
KR101871133B1 (en) * 2013-03-13 2018-06-25 에프. 호프만-라 로슈 아게 Process for making benzoxazepin compounds
US9364405B2 (en) 2013-03-13 2016-06-14 Avon Products, Inc. Tyrosinase inhibitors
WO2014164200A1 (en) 2013-03-13 2014-10-09 Avon Products, Inc Tyrosinase inhibitors
US20150152122A1 (en) * 2013-03-13 2015-06-04 Avon Products, Inc. Tyrosinase inhibitors
WO2014174478A1 (en) 2013-04-26 2014-10-30 Novartis Ag Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor
AU2014262326B2 (en) * 2013-05-10 2018-03-22 Jiangsu Hansoh Pharmaceutical Co., Ltd. [1,2,4] triazol [4,3-a] pyridine derivate, preparation method therefor or medical application thereof
CN105272995B (en) 2015-09-24 2017-10-27 上海海聚生物科技有限公司 Quinoline derivatives, its pharmaceutical composition, preparation method and application

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5604091A (en) 1984-03-01 1997-02-18 Microgenics Corporation Methods for protein binding enzyme complementation
JPS60194443A (en) * 1984-03-16 1985-10-02 Fuji Photo Film Co Ltd Photosensitive silver halide material
EP0228061A3 (en) 1985-12-23 1988-12-14 Takeda Chemical Industries, Ltd. Cephem compounds
JPS62228086A (en) * 1985-12-23 1987-10-06 Takeda Chem Ind Ltd Cephem compound
GB9918035D0 (en) 1999-07-30 1999-09-29 Novartis Ag Organic compounds
WO2002083139A1 (en) * 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibitors of akt activity
US6960584B2 (en) * 2001-04-10 2005-11-01 Merck & Co., Inc. Inhibitors of Akt activity
US20030229453A1 (en) 2002-04-09 2003-12-11 Antonysamy Stephen Suresh Crystals and structures of PAK4KD kinase PAK4KD
NZ541151A (en) * 2002-12-18 2008-09-26 Vertex Pharma Triazolopyridazines as protein kinase inhibitors
US7122548B2 (en) * 2003-07-02 2006-10-17 Sugen, Inc. Triazolotriazine compounds and uses thereof
EP1778687A2 (en) * 2004-07-27 2007-05-02 SGX Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
AU2005276132B2 (en) 2004-08-26 2011-09-29 Pfizer Inc. Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
CA2590261C (en) 2004-12-27 2011-08-16 Alcon, Inc. Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases and conditions

Also Published As

Publication number Publication date
BRPI0717320A2 (en) 2013-10-22
AR063520A1 (en) 2009-01-28
EP2084162A2 (en) 2009-08-05
SV2009003235A (en) 2009-10-15
WO2008051808A3 (en) 2008-07-24
AU2007309149C1 (en) 2013-04-04
ES2393130T3 (en) 2012-12-18
PT2084162E (en) 2012-10-09
NZ575336A (en) 2012-04-27
EP2084162B1 (en) 2012-09-12
MX2009004059A (en) 2009-04-27
EA200970403A1 (en) 2009-10-30
PE20080893A1 (en) 2008-08-26
TW200835492A (en) 2008-09-01
TN2009000142A1 (en) 2010-10-18
US8507489B2 (en) 2013-08-13
US20090258855A1 (en) 2009-10-15
PL2084162T3 (en) 2013-01-31
JP5378222B2 (en) 2013-12-25
CO6190620A2 (en) 2010-08-19
MA30871B1 (en) 2009-11-02
JP2010507578A (en) 2010-03-11
KR20090071612A (en) 2009-07-01
CA2667428A1 (en) 2008-05-02
AU2007309149A1 (en) 2008-05-02
DK2084162T3 (en) 2012-10-01
WO2008051808A2 (en) 2008-05-02
CR10803A (en) 2009-06-16
NO20091618L (en) 2009-05-22
AU2007309149B2 (en) 2012-09-06

Similar Documents

Publication Publication Date Title
IL197958A0 (en) Bicyclic triazoles as protein kinase modulators
ZA200902170B (en) Bicyclic triazoles as protein kinase modulators
PL2081937T3 (en) Triazolopyridazine protein kinase modulators
EP2259678A4 (en) Protein kinase modulators
IL197015A0 (en) Benzotriazole kinase modulators
IL206416A0 (en) Benzofuropyrimidinones as protein kinase inhibitors
PT2200436E (en) Substituted pyrimidinyl-amines as protein kinase inhibitors
PL2193133T3 (en) Imidazolothiadiazoles for use as protein kinase inhibitors
LT3118220T (en) Protein
SI2303891T1 (en) Pyrazolo-quinazolines as protein kinase activity modulators
IL197960A0 (en) Bicyclic heteroaromatic compounds
EP2083625A4 (en) Bicyclic heteroaromatic compounds
HK1208701A1 (en) Means for inhibiting the expression of protein kinase
GB0611116D0 (en) Proteins
GB0601976D0 (en) Proteins
GB0620735D0 (en) Proteins
GB0409080D0 (en) Compounds which interact with protein kinases
GB0719231D0 (en) Protein
EP2024516A4 (en) Perforin-2 proteins
ZA200810573B (en) Substituted 3-cyanopyridines as protein kinase inhibitors
GB0612443D0 (en) Protein
GB0620304D0 (en) Protein
GB0720563D0 (en) Protein
GB0614682D0 (en) Proteins
GB0612623D0 (en) Proteins