IL184671A0 - Substances directed to heparanase c-terminal domain-or substance derived therefrom and uses thereof as modulators of heparanas biological activities - Google Patents

Substances directed to heparanase c-terminal domain-or substance derived therefrom and uses thereof as modulators of heparanas biological activities

Info

Publication number
IL184671A0
IL184671A0 IL184671A IL18467107A IL184671A0 IL 184671 A0 IL184671 A0 IL 184671A0 IL 184671 A IL184671 A IL 184671A IL 18467107 A IL18467107 A IL 18467107A IL 184671 A0 IL184671 A0 IL 184671A0
Authority
IL
Israel
Prior art keywords
heparanas
heparanase
modulators
derived therefrom
biological activities
Prior art date
Application number
IL184671A
Original Assignee
Hadasit Med Res Service
Israel Vlodavsky
Neta Ilan
Liat Fux
Sevtlana Gingis Velitski
Itay Shafat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hadasit Med Res Service, Israel Vlodavsky, Neta Ilan, Liat Fux, Sevtlana Gingis Velitski, Itay Shafat filed Critical Hadasit Med Res Service
Priority to IL184671A priority Critical patent/IL184671A0/en
Priority to PCT/IL2008/000952 priority patent/WO2009010957A2/en
Publication of IL184671A0 publication Critical patent/IL184671A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01166—Heparanase (3.2.1.166)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
IL184671A 2007-07-17 2007-07-17 Substances directed to heparanase c-terminal domain-or substance derived therefrom and uses thereof as modulators of heparanas biological activities IL184671A0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL184671A IL184671A0 (en) 2007-07-17 2007-07-17 Substances directed to heparanase c-terminal domain-or substance derived therefrom and uses thereof as modulators of heparanas biological activities
PCT/IL2008/000952 WO2009010957A2 (en) 2007-07-17 2008-07-10 Heparanase c-terminal domain, sequences derived therefrom, substances directed against said domain and uses thereof as modulators of heparanase biological activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL184671A IL184671A0 (en) 2007-07-17 2007-07-17 Substances directed to heparanase c-terminal domain-or substance derived therefrom and uses thereof as modulators of heparanas biological activities

Publications (1)

Publication Number Publication Date
IL184671A0 true IL184671A0 (en) 2008-12-29

Family

ID=40139137

Family Applications (1)

Application Number Title Priority Date Filing Date
IL184671A IL184671A0 (en) 2007-07-17 2007-07-17 Substances directed to heparanase c-terminal domain-or substance derived therefrom and uses thereof as modulators of heparanas biological activities

Country Status (2)

Country Link
IL (1) IL184671A0 (en)
WO (1) WO2009010957A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104812898B (en) 2012-05-25 2018-01-30 博格有限责任公司 The method for treating metabolic syndrome by adjusting the β of heat shock protein (HSP) 90
US10023864B2 (en) 2014-06-06 2018-07-17 Berg Llc Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-beta
EP3362093A4 (en) 2015-10-13 2019-05-08 Technion Research & Development Foundation Limited Heparanase-neutralizing monoclonal antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004201462C9 (en) * 1997-09-02 2008-03-13 Hadasit Medical Research Services And Development Ltd. Antibodies Recognising At Least One Epitope of Heparanase
US6562950B2 (en) * 1997-09-02 2003-05-13 Insight Strategy & Marketing Ltd. Heparanase activity neutralizing anti-heparanase monoclonal antibody
EP1479764A1 (en) * 2003-05-19 2004-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Heparanase-derived peptides for vaccination of tumor patients
IL160025A0 (en) * 2004-01-22 2004-06-20 Hadasit Med Res Service Heparanase inhibitors directed against a specific sequence essential for heparanase catalytic activity and uses thereof

Also Published As

Publication number Publication date
WO2009010957A3 (en) 2009-04-30
WO2009010957A2 (en) 2009-01-22

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