IL165056A0 - Spliceosome mediated rna trans-splicing - Google Patents
Spliceosome mediated rna trans-splicingInfo
- Publication number
- IL165056A0 IL165056A0 IL16505602A IL16505602A IL165056A0 IL 165056 A0 IL165056 A0 IL 165056A0 IL 16505602 A IL16505602 A IL 16505602A IL 16505602 A IL16505602 A IL 16505602A IL 165056 A0 IL165056 A0 IL 165056A0
- Authority
- IL
- Israel
- Prior art keywords
- splicing
- mediated rna
- rna trans
- spliceosome mediated
- spliceosome
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
- C12N2840/445—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor for trans-splicing, e.g. polypyrimidine tract, branch point splicing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Transplantation (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/756,096 US20030077754A1 (en) | 1995-12-15 | 2001-01-08 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
US09/756,097 US20060088938A1 (en) | 1995-12-15 | 2001-01-08 | Methods and compositions for use in spliceosome mediated RNA trans-splicing in plants |
US09/756,095 US20020115207A1 (en) | 1995-12-15 | 2001-01-08 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
US09/838,858 US20030148937A1 (en) | 1995-12-15 | 2001-04-20 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
US09/941,492 US20030027250A1 (en) | 1995-12-15 | 2001-08-29 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
PCT/US2002/000416 WO2002053581A2 (en) | 2001-01-08 | 2002-01-08 | Spliceosome mediated rna trans-splicing |
Publications (1)
Publication Number | Publication Date |
---|---|
IL165056A0 true IL165056A0 (en) | 2005-12-18 |
Family
ID=27542170
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15666502A IL156665A0 (en) | 2001-01-08 | 2002-01-08 | Spliceosome mediated rna trans-splicing |
IL16505602A IL165056A0 (en) | 2001-01-08 | 2002-01-08 | Spliceosome mediated rna trans-splicing |
IL16505704A IL165057A0 (en) | 2001-01-08 | 2004-11-04 | Spliceosome mediated rna trans-splicing |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15666502A IL156665A0 (en) | 2001-01-08 | 2002-01-08 | Spliceosome mediated rna trans-splicing |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16505704A IL165057A0 (en) | 2001-01-08 | 2004-11-04 | Spliceosome mediated rna trans-splicing |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1358203A4 (en) |
JP (3) | JP2004525618A (en) |
AU (1) | AU2002246959B2 (en) |
CA (1) | CA2434118A1 (en) |
IL (3) | IL156665A0 (en) |
WO (1) | WO2002053581A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10139492B4 (en) * | 2001-08-13 | 2004-06-09 | Eul, Joachim, Dr. | Process for the repair of a mutated RNA from a gene-defective DNA and for the targeted killing of tumor cells by RNA trans-splicing as well as process for the detection of naturally trans-spliced cellular RNA |
WO2003104412A2 (en) | 2002-06-05 | 2003-12-18 | Intronn, Inc. | Spliceosome mediated rna trans-splicing and correction of factor viii genetic defects using spliceosome mediated rna trans spling |
CA2553828A1 (en) * | 2004-01-23 | 2005-08-04 | Intronn, Inc. | Expression of apoa-1 and variants thereof using spliceosome mediated rna trans-splicing |
AU2005326784B2 (en) * | 2004-10-08 | 2012-03-15 | Virxsys Corporation | Use of RNA trans-splicing for antibody gene transfer and antibody polypeptide production |
JP5017118B2 (en) * | 2004-10-08 | 2012-09-05 | バークシス コーポレーション | Targeted trans-splicing of highly abundant transcripts for in vivo production of recombinant proteins |
JP5081462B2 (en) * | 2007-02-02 | 2012-11-28 | 富士フイルム株式会社 | Fusion protein production method by trans-splicing method |
CA2844930A1 (en) * | 2011-08-12 | 2013-02-21 | Virxsys Corporation | Compositions and methods for inducing apoptosis |
EP3680336A1 (en) * | 2014-07-03 | 2020-07-15 | F. Hoffmann-La Roche AG | Polypeptide expression systems |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6280978B1 (en) * | 1995-12-15 | 2001-08-28 | Intronn Holdings, Llc | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
CA2240494C (en) * | 1995-12-15 | 2007-03-13 | Lloyd G. Mitchell | Therapeutic molecules generated by trans-splicing |
-
2002
- 2002-01-08 IL IL15666502A patent/IL156665A0/en unknown
- 2002-01-08 JP JP2002555104A patent/JP2004525618A/en active Pending
- 2002-01-08 EP EP02714709A patent/EP1358203A4/en not_active Withdrawn
- 2002-01-08 CA CA002434118A patent/CA2434118A1/en not_active Abandoned
- 2002-01-08 IL IL16505602A patent/IL165056A0/en unknown
- 2002-01-08 AU AU2002246959A patent/AU2002246959B2/en not_active Ceased
- 2002-01-08 WO PCT/US2002/000416 patent/WO2002053581A2/en active Application Filing
-
2004
- 2004-11-04 IL IL16505704A patent/IL165057A0/en unknown
-
2005
- 2005-01-07 JP JP2005003076A patent/JP2005176849A/en active Pending
- 2005-01-07 JP JP2005003107A patent/JP2005168509A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2004525618A (en) | 2004-08-26 |
AU2002246959B2 (en) | 2008-03-06 |
IL165057A0 (en) | 2005-12-18 |
CA2434118A1 (en) | 2002-07-11 |
WO2002053581A2 (en) | 2002-07-11 |
JP2005168509A (en) | 2005-06-30 |
EP1358203A2 (en) | 2003-11-05 |
WO2002053581A3 (en) | 2002-09-26 |
JP2005176849A (en) | 2005-07-07 |
IL156665A0 (en) | 2004-01-04 |
EP1358203A4 (en) | 2006-11-22 |
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