IL151620A0 - Methods of making and using microarrays of anti-ligands for the analysis of protein expression in cells - Google Patents

Methods of making and using microarrays of anti-ligands for the analysis of protein expression in cells

Info

Publication number
IL151620A0
IL151620A0 IL15162001A IL15162001A IL151620A0 IL 151620 A0 IL151620 A0 IL 151620A0 IL 15162001 A IL15162001 A IL 15162001A IL 15162001 A IL15162001 A IL 15162001A IL 151620 A0 IL151620 A0 IL 151620A0
Authority
IL
Israel
Prior art keywords
microarrays
ligands
cells
analysis
making
Prior art date
Application number
IL15162001A
Other languages
English (en)
Original Assignee
Bioinvent Int Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioinvent Int Ab filed Critical Bioinvent Int Ab
Publication of IL151620A0 publication Critical patent/IL151620A0/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • B01J2219/00743—Cells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Electrostatic Separation (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
IL15162001A 2000-03-17 2001-03-06 Methods of making and using microarrays of anti-ligands for the analysis of protein expression in cells IL151620A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0006425A GB2360282A (en) 2000-03-17 2000-03-17 Making and using micro-arrays of biological materials
PCT/EP2001/002520 WO2001069247A2 (en) 2000-03-17 2001-03-06 Methods of making and using microarrays of anti-ligands for the analysis of protein expression in cells

Publications (1)

Publication Number Publication Date
IL151620A0 true IL151620A0 (en) 2003-04-10

Family

ID=9887796

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15162001A IL151620A0 (en) 2000-03-17 2001-03-06 Methods of making and using microarrays of anti-ligands for the analysis of protein expression in cells

Country Status (9)

Country Link
US (1) US20040067539A1 (ja)
EP (1) EP1263990A2 (ja)
JP (1) JP2003527605A (ja)
AU (1) AU2001252160A1 (ja)
CA (1) CA2402424A1 (ja)
GB (1) GB2360282A (ja)
IL (1) IL151620A0 (ja)
NO (1) NO20024413L (ja)
WO (1) WO2001069247A2 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7329489B2 (en) 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
EP1285092A4 (en) 2000-04-14 2003-07-16 Metabolon Inc METHOD FOR DISCOVERY OF MEDICINES, DISEASE TREATMENT AND DIAGNOSIS USE THE METABOLOMICS
WO2003029490A1 (en) * 2001-10-01 2003-04-10 Yingjian Wang Methods and arrays for detecting biological molecules
GB0305656D0 (en) * 2003-03-12 2003-04-16 Bioinvent Int Ab Screening assay
JP3944576B2 (ja) * 2003-03-28 2007-07-11 独立行政法人産業技術総合研究所 マイクロアレイを用いたアプタマーの取得方法
US8012693B2 (en) 2003-12-16 2011-09-06 3M Innovative Properties Company Analysis of chemically crosslinked cellular samples
WO2005064333A1 (ja) 2003-12-25 2005-07-14 National Institute Of Advanced Industrial Science And Technology タンパク質と糖鎖との相互作用を分析する方法
US7799556B2 (en) * 2004-06-17 2010-09-21 George Dacai Liu System and method for antigen structure-independent detection of antigens captured on antibody arrays
US20060292559A1 (en) * 2005-06-23 2006-12-28 Beckman Coulter, Inc. Cell-based microarrays, and methods for their preparation and use
WO2008033575A2 (en) 2006-09-15 2008-03-20 Metabolon, Inc. Methods of identifying biochemical pathways
US20110028339A1 (en) * 2007-11-30 2011-02-03 Richard Jones Methods and compositions related to microscale sample processing and evaluation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5707798A (en) * 1993-07-13 1998-01-13 Novo Nordisk A/S Identification of ligands by selective amplification of cells transfected with receptors
US5856090A (en) * 1994-09-09 1999-01-05 The Scripps Research Institute DNA-methylase linking reaction
AU1127097A (en) * 1995-12-15 1997-07-14 Pharmacia & Upjohn Company Method for the simultaneous detection of a therapeutic target for a disease state and its neutralizing antibody-like molecule
GB9703369D0 (en) * 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
US6485944B1 (en) * 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
AU1925699A (en) * 1997-12-18 1999-07-05 Sepracor, Inc. Methods for the simultaneous identification of novel biological targets and leadstructures for drug development
US20030044838A1 (en) * 1998-01-14 2003-03-06 Charles L. Turnbough Peptide ligands that bind to surfaces of bacterial spores
US6537749B2 (en) * 1998-04-03 2003-03-25 Phylos, Inc. Addressable protein arrays
ATE437844T1 (de) * 1998-08-17 2009-08-15 Bristol Myers Squibb Co Identifizierung von verbindung-protein wechselwirkungen mit bibliotheken von gekoppelten protein-nukleinsäure-molekülen
EP1140137A2 (en) * 1998-12-18 2001-10-10 Scios Inc. Method for detection and use of differentially expressed genes in disease states
WO2000049417A1 (en) * 1999-02-17 2000-08-24 Arcaris, Inc. Methods for substrate-ligand interaction screening
CA2368875A1 (en) * 1999-04-14 2000-10-19 The Government Of The United States Of America High sensitivity phage display biomolecule detection

Also Published As

Publication number Publication date
US20040067539A1 (en) 2004-04-08
CA2402424A1 (en) 2001-09-20
GB2360282A (en) 2001-09-19
JP2003527605A (ja) 2003-09-16
WO2001069247A3 (en) 2002-03-28
EP1263990A2 (en) 2002-12-11
NO20024413L (no) 2002-11-13
WO2001069247A2 (en) 2001-09-20
GB0006425D0 (en) 2000-05-03
AU2001252160A1 (en) 2001-09-24
NO20024413D0 (no) 2002-09-16

Similar Documents

Publication Publication Date Title
AU3459301A (en) Compositions and methods for performing biological reactions
IL228034A0 (en) Formulations with a high concentration of antibodies and proteins
AU4907901A (en) Protein matrix materials, devices and methods of making and using thereof
IL161976A0 (en) Cell and tissue arrays and microarrays and methodsof use
IL192111A0 (en) Human receptor proteins; related reagents and methods
EP1390747A4 (en) SYSTEMS AND METHOD FOR THE AUTOMATIC ANALYSIS OF CELLS AND WOVEN FABRICS
AU2002243587A1 (en) Microfluidic apparatus for performing gel protein extractions and methods for using the apparatus
IL155952A0 (en) Expression analysis of fkbp nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
AU2002309865A1 (en) Methods for analyzing interactions between proteins in live and intact cells
IL151620A0 (en) Methods of making and using microarrays of anti-ligands for the analysis of protein expression in cells
EP1581637A4 (en) MATERIALS AND METHODS WITH HUMAN STEM CELLS
GB2399819B (en) Method and lentiviral vector for transducing human embryonic stem cells
AU2003254196A8 (en) Methods for producing biological substances in pigment-deficient mutants of bacillus cells
GB0022748D0 (en) Reducing the content of cells in a biological sample
GB0119497D0 (en) Expression of modified antibodies in avian cells
AU2001236064A1 (en) Method for analysis of substances in tissue or in cells
GB2361699B (en) Analysis of complex biological mixtures
AU2003253675A8 (en) Methods for protein analyses and protein expression in multicellular organisms and cells therefrom
HUP0303899A3 (en) Expression analysis of smarc nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
AU2003258690A8 (en) Method for the identification of proteins specific for renal cell carcinoma and use thereof
GB0130675D0 (en) Improvements in and relating to analysis
GB0114639D0 (en) Improvements in and relating to analysis of DNA
AU2002313239A1 (en) Method of analyzing protein occurring in cell or substance interacting with the protein
GB0116478D0 (en) Materials and methods relating to protein evolution
GB0211835D0 (en) Materials and method for lactose-inducible protein expression in bacterial cells