IL147774A0 - Hydroxyalkanoyl aminolactams and related structures as inhibitors of as protein production - Google Patents
Hydroxyalkanoyl aminolactams and related structures as inhibitors of as protein productionInfo
- Publication number
- IL147774A0 IL147774A0 IL14777400A IL14777400A IL147774A0 IL 147774 A0 IL147774 A0 IL 147774A0 IL 14777400 A IL14777400 A IL 14777400A IL 14777400 A IL14777400 A IL 14777400A IL 147774 A0 IL147774 A0 IL 147774A0
- Authority
- IL
- Israel
- Prior art keywords
- aminolactams
- hydroxyalkanoyl
- inhibitors
- protein production
- related structures
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15351199P | 1999-09-13 | 1999-09-13 | |
| US22438800P | 2000-08-09 | 2000-08-09 | |
| PCT/US2000/024967 WO2001019797A2 (en) | 1999-09-13 | 2000-09-13 | HYDROXYALKANOYL AMINOLACTAMS AND RELATED STRUCTURES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL147774A0 true IL147774A0 (en) | 2002-08-14 |
Family
ID=26850619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14777400A IL147774A0 (en) | 1999-09-13 | 2000-09-13 | Hydroxyalkanoyl aminolactams and related structures as inhibitors of as protein production |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1212306A2 (en) |
| JP (1) | JP2003509411A (en) |
| CN (1) | CN1399634A (en) |
| AU (1) | AU783914B2 (en) |
| BR (1) | BR0014269A (en) |
| CA (1) | CA2377221A1 (en) |
| IL (1) | IL147774A0 (en) |
| MX (1) | MXPA02001813A (en) |
| WO (1) | WO2001019797A2 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
| CA2401749A1 (en) | 2000-03-23 | 2001-09-27 | Elan Pharmaceuticals, Inc. | Compounds and methods to treat alzheimer's disease |
| JP2004508289A (en) | 2000-04-03 | 2004-03-18 | デュポン ファーマシューティカルズ カンパニー | Cyclic lactams as inhibitors of Aβ protein production |
| WO2001077086A1 (en) * | 2000-04-11 | 2001-10-18 | Dupont Pharmaceuticals Company | SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| AU2001261728A1 (en) | 2000-05-17 | 2001-11-26 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| EP1666452A2 (en) | 2000-06-30 | 2006-06-07 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| PE20020276A1 (en) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | SUBSTITUTE AMINE COMPOUNDS AS ß-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER |
| EP1466898A4 (en) * | 2001-12-27 | 2005-12-07 | Daiichi Seiyaku Co | Beta-amyloid protein production/secretion inhibitors |
| US6974829B2 (en) | 2002-05-07 | 2005-12-13 | Elan Pharmaceuticals, Inc. | Succinoyl aminopyrazoles and related compounds |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| WO2005009344A2 (en) | 2003-06-05 | 2005-02-03 | Elan Pharmaceuticals, Inc. | Acylated amino acid amidyl pyrazoles and related compounds |
| EP2121633A2 (en) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| JP2010526825A (en) | 2007-05-10 | 2010-08-05 | エーエムアール テクノロジー インコーポレイテッド | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and their use to block reuptake of norepinephrine, dopamine and serotonin |
| CA2709677C (en) | 2007-12-21 | 2017-03-14 | Lin Zhi | Selective androgen receptor modulators (sarms) and uses thereof |
| US8461389B2 (en) | 2008-04-18 | 2013-06-11 | University College Dublin, National University Of Ireland, Dublin | Psycho-pharmaceuticals |
| US10441567B2 (en) | 2014-01-17 | 2019-10-15 | Ligand Pharmaceuticals Incorporated | Methods and compositions for modulating hormone levels |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666829A (en) | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
| IL129504A0 (en) * | 1996-11-22 | 2000-02-29 | Elan Pharm Inc | N-(aryl/heteroaryl/alkylacetyl) amino acid amides pharmaceutical compositions comprising same and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds |
| CN1171878C (en) | 1996-12-23 | 2004-10-20 | 伊兰药品公司 | Cycloalkyl, lactam lactone and related compounds as 'beta'-amyloid peptide release inhibitors |
| WO1999032453A1 (en) * | 1997-12-22 | 1999-07-01 | Elan Pharmaceuticals, Inc. | POLYCYCLIC α-AMINO-⊂-CAPROLACTAMS AND RELATED COMPOUNDS |
| WO1999066934A1 (en) | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| JP4615727B2 (en) | 1998-12-24 | 2011-01-19 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Succinoylaminobenzodiazepine as an inhibitor of Aβ protein production |
-
2000
- 2000-09-13 IL IL14777400A patent/IL147774A0/en unknown
- 2000-09-13 JP JP2001523377A patent/JP2003509411A/en active Pending
- 2000-09-13 WO PCT/US2000/024967 patent/WO2001019797A2/en active IP Right Grant
- 2000-09-13 AU AU74797/00A patent/AU783914B2/en not_active Ceased
- 2000-09-13 BR BR0014269-7A patent/BR0014269A/en not_active Application Discontinuation
- 2000-09-13 CA CA002377221A patent/CA2377221A1/en not_active Abandoned
- 2000-09-13 CN CN00812784A patent/CN1399634A/en active Pending
- 2000-09-13 EP EP00963374A patent/EP1212306A2/en not_active Withdrawn
- 2000-09-13 MX MXPA02001813A patent/MXPA02001813A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2377221A1 (en) | 2001-03-22 |
| AU7479700A (en) | 2001-04-17 |
| BR0014269A (en) | 2002-07-02 |
| CN1399634A (en) | 2003-02-26 |
| WO2001019797A2 (en) | 2001-03-22 |
| AU783914B2 (en) | 2005-12-22 |
| JP2003509411A (en) | 2003-03-11 |
| EP1212306A2 (en) | 2002-06-12 |
| MXPA02001813A (en) | 2004-03-19 |
| WO2001019797A3 (en) | 2002-04-11 |
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