IL145720A0 - Pharmaceutical compositions containing liposome-encapsulated vinca alkaloids - Google Patents
Pharmaceutical compositions containing liposome-encapsulated vinca alkaloidsInfo
- Publication number
- IL145720A0 IL145720A0 IL14572000A IL14572000A IL145720A0 IL 145720 A0 IL145720 A0 IL 145720A0 IL 14572000 A IL14572000 A IL 14572000A IL 14572000 A IL14572000 A IL 14572000A IL 145720 A0 IL145720 A0 IL 145720A0
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- vinca alkaloids
- containing liposome
- mol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Abstract
Liposome-encapsulated vincristine is provided for treating a cancer such as a lymphoma, leukaemia or myeloma and especially non-Hodgkin's Lymphoma or Acute Lymphocytic Leukaemia. The liposomes comprise sphingomyelin and cholesterol in a ratio between 75/25 (mol % sphingomyelin/mol % cholesterol) and 50/50 (mol % sphingomyelin/mol % cholesterol) and vincristine at a concentration of 0.1 to 0.5 mg/ml.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12744499P | 1999-04-01 | 1999-04-01 | |
US13719499P | 1999-06-02 | 1999-06-02 | |
PCT/US2000/008669 WO2000059473A1 (en) | 1999-04-01 | 2000-03-31 | Compositions and methods for treating lymphoma |
Publications (1)
Publication Number | Publication Date |
---|---|
IL145720A0 true IL145720A0 (en) | 2002-07-25 |
Family
ID=26825635
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14572000A IL145720A0 (en) | 1999-04-01 | 2000-03-31 | Pharmaceutical compositions containing liposome-encapsulated vinca alkaloids |
IL145720A IL145720A (en) | 1999-04-01 | 2001-09-30 | Use of a liposome encapsulated vincristine for the preparation of a pharmaceutical composition for treating cancer |
IL212389A IL212389A (en) | 1999-04-01 | 2011-04-14 | Compositions comprising liposome-encapsulated vincristine for use in treating cancer |
IL212390A IL212390A (en) | 1999-04-01 | 2011-04-14 | Compositions comprising liposome-encapsulated vincristine for use in treating cancer |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL145720A IL145720A (en) | 1999-04-01 | 2001-09-30 | Use of a liposome encapsulated vincristine for the preparation of a pharmaceutical composition for treating cancer |
IL212389A IL212389A (en) | 1999-04-01 | 2011-04-14 | Compositions comprising liposome-encapsulated vincristine for use in treating cancer |
IL212390A IL212390A (en) | 1999-04-01 | 2011-04-14 | Compositions comprising liposome-encapsulated vincristine for use in treating cancer |
Country Status (14)
Country | Link |
---|---|
EP (3) | EP1169021B1 (en) |
JP (3) | JP2002541088A (en) |
AT (1) | ATE442839T1 (en) |
AU (1) | AU777572B2 (en) |
BR (1) | BRPI0009448B8 (en) |
CA (1) | CA2366787C (en) |
CY (1) | CY1109641T1 (en) |
DE (1) | DE60042968D1 (en) |
DK (2) | DK2266537T3 (en) |
ES (2) | ES2524141T3 (en) |
HK (1) | HK1152246A1 (en) |
IL (4) | IL145720A0 (en) |
PT (1) | PT1169021E (en) |
WO (1) | WO2000059473A1 (en) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0009448B8 (en) * | 1999-04-01 | 2021-05-25 | Univ Texas | kit for use in treating a neoplasm in a mammal |
US6723338B1 (en) | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
EP2266607A3 (en) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Immunoconjugates for treating cancer |
US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
GB0000313D0 (en) | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
AU2002312777B2 (en) * | 2001-03-27 | 2007-07-05 | Phares Pharmaceutical Research N.V. | Method and composition for solubilising a biologically active compound with low water solubility |
WO2003097052A2 (en) * | 2002-05-17 | 2003-11-27 | Celgene Corporation | Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases |
FR2840203B1 (en) * | 2002-05-31 | 2004-08-27 | Scherer Technologies Inc R P | ORAL PHARMACEUTICAL COMPOSITION FOR SOFT CAPSULES CONTAINING VINORELBINE AND METHOD OF TREATMENT |
US6890558B2 (en) | 2002-05-31 | 2005-05-10 | R.P. Scherer Technologies, Inc. | Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment |
US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
WO2005011698A1 (en) * | 2003-07-28 | 2005-02-10 | Inex Pharmaceuticals Corporation | Combination comprising a liposome-encapsulated vinca alkaloid and a topoisomerase ii inhibitor and the use thereof for treating neoplasia |
RU2394596C2 (en) * | 2004-07-09 | 2010-07-20 | Байер Шеринг Фарма Акциенгезельшафт | Combined therapy by radioactively marked antibody anti-cd20 in treatment of b-cellular lymphoma |
DK1781255T3 (en) * | 2004-08-10 | 2012-05-29 | Talon Therapeutics Inc | Compositions and Methods for Treating Leukemia |
EP2190429B1 (en) * | 2007-09-10 | 2016-04-20 | Boston Biomedical, Inc. | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors |
EP3692988A3 (en) | 2008-03-18 | 2020-10-14 | Genentech, Inc. | Combinations of an anti-her2 antibody-drug conjugate and 5-fu, anti-vegf antibody, carboplatin or abt-869 and methods of use |
JP2012506428A (en) * | 2008-10-24 | 2012-03-15 | グルオウセステル プハルマセウトイカルス | Cancer therapy |
TR201908531T4 (en) * | 2012-11-20 | 2019-08-21 | Arbutus Biopharma Corp | ADVANCED METHOD FOR PREPARATION OF LIPOSOME CAPSULATED VINCRYSTINE FOR THERAPEUTIC USE |
WO2014116866A1 (en) * | 2013-01-24 | 2014-07-31 | Memorial Sloan Kettering Cancer Center | Method for diagnosing or treating tumors using sphingomyelin containing liposomes |
BR112015025347A2 (en) | 2013-04-09 | 2017-07-18 | Boston Biomedical Inc | 2-acetyl naphtho [2-3-b] furan-4,9-dione for use in cancer treatment |
TWI678213B (en) * | 2015-07-22 | 2019-12-01 | 美商史倍壯製藥公司 | A ready-to-use formulation for vincristine sulfate liposome injection |
JP7106563B2 (en) | 2016-11-29 | 2022-07-26 | スミトモ ファーマ オンコロジー, インコーポレイテッド | Naphthofuran derivatives, their preparation and methods of use |
US10646464B2 (en) | 2017-05-17 | 2020-05-12 | Boston Biomedical, Inc. | Methods for treating cancer |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4217344A (en) | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4186183A (en) | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
US4261975A (en) | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
US4603044A (en) | 1983-01-06 | 1986-07-29 | Technology Unlimited, Inc. | Hepatocyte Directed Vesicle delivery system |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US5077056A (en) | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
US5736155A (en) | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
US4946787A (en) | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4885172A (en) | 1985-06-26 | 1989-12-05 | The Liposome Company, Inc. | Composition for targeting, storing and loading of liposomes |
US5059421A (en) | 1985-07-26 | 1991-10-22 | The Liposome Company, Inc. | Preparation of targeted liposome systems of a defined size distribution |
US5171578A (en) | 1985-06-26 | 1992-12-15 | The Liposome Company, Inc. | Composition for targeting, storing and loading of liposomes |
US4774085A (en) | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US4952408A (en) * | 1988-05-23 | 1990-08-28 | Georgetown University | Liposome-encapsulated vinca alkaloids and their use in combatting tumors |
US4957773A (en) | 1989-02-13 | 1990-09-18 | Syracuse University | Deposition of boron-containing films from decaborane |
WO1991017424A1 (en) | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
US5165922A (en) * | 1990-05-22 | 1992-11-24 | Bristol-Myers Squibb Company | Synergistic tumor therapy with combinations of biologically active anti-tumor antibodies and chemotherapy |
GB9304745D0 (en) * | 1993-03-09 | 1993-04-28 | Oncholab Ab | Use of pharmaceutical formulations |
US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
US5543152A (en) * | 1994-06-20 | 1996-08-06 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
US5714163A (en) * | 1994-06-27 | 1998-02-03 | Nexstar Pharmaceuticals, Inc. | Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties |
US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
US5837282A (en) | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
BRPI0009448B8 (en) * | 1999-04-01 | 2021-05-25 | Univ Texas | kit for use in treating a neoplasm in a mammal |
-
2000
- 2000-03-31 BR BRPI0009448A patent/BRPI0009448B8/en not_active IP Right Cessation
- 2000-03-31 DE DE60042968T patent/DE60042968D1/en not_active Expired - Lifetime
- 2000-03-31 PT PT00920004T patent/PT1169021E/en unknown
- 2000-03-31 DK DK10011105.3T patent/DK2266537T3/en active
- 2000-03-31 ES ES10011105.3T patent/ES2524141T3/en not_active Expired - Lifetime
- 2000-03-31 JP JP2000609037A patent/JP2002541088A/en active Pending
- 2000-03-31 AT AT00920004T patent/ATE442839T1/en active
- 2000-03-31 AU AU40606/00A patent/AU777572B2/en not_active Expired
- 2000-03-31 CA CA2366787A patent/CA2366787C/en not_active Expired - Lifetime
- 2000-03-31 EP EP00920004A patent/EP1169021B1/en not_active Expired - Lifetime
- 2000-03-31 ES ES00920004T patent/ES2333400T3/en not_active Expired - Lifetime
- 2000-03-31 EP EP08003804A patent/EP1985285A3/en not_active Withdrawn
- 2000-03-31 IL IL14572000A patent/IL145720A0/en unknown
- 2000-03-31 DK DK00920004T patent/DK1169021T3/en active
- 2000-03-31 WO PCT/US2000/008669 patent/WO2000059473A1/en active Application Filing
- 2000-03-31 EP EP10011105.3A patent/EP2266537B1/en not_active Expired - Lifetime
-
2001
- 2001-09-30 IL IL145720A patent/IL145720A/en not_active IP Right Cessation
-
2009
- 2009-11-17 CY CY20091101201T patent/CY1109641T1/en unknown
-
2011
- 2011-04-14 IL IL212389A patent/IL212389A/en not_active IP Right Cessation
- 2011-04-14 IL IL212390A patent/IL212390A/en not_active IP Right Cessation
- 2011-06-22 HK HK11106406.2A patent/HK1152246A1/en not_active IP Right Cessation
-
2012
- 2012-05-01 JP JP2012104769A patent/JP5981214B2/en not_active Expired - Lifetime
-
2014
- 2014-12-04 JP JP2014246221A patent/JP2015071631A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU4060600A (en) | 2000-10-23 |
HK1152246A1 (en) | 2012-02-24 |
BRPI0009448B1 (en) | 2018-09-11 |
IL212390A0 (en) | 2011-06-30 |
EP2266537A2 (en) | 2010-12-29 |
JP2012158602A (en) | 2012-08-23 |
IL212389A0 (en) | 2011-06-30 |
EP2266537A3 (en) | 2012-02-22 |
DK1169021T3 (en) | 2010-01-11 |
EP1985285A3 (en) | 2009-08-12 |
CY1109641T1 (en) | 2014-08-13 |
ATE442839T1 (en) | 2009-10-15 |
IL212389A (en) | 2015-07-30 |
PT1169021E (en) | 2009-11-18 |
WO2000059473A1 (en) | 2000-10-12 |
CA2366787C (en) | 2013-03-12 |
AU777572B2 (en) | 2004-10-21 |
DE60042968D1 (en) | 2009-10-29 |
EP1169021B1 (en) | 2009-09-16 |
IL145720A (en) | 2011-05-31 |
EP2266537B1 (en) | 2014-09-03 |
JP2015071631A (en) | 2015-04-16 |
EP1169021A1 (en) | 2002-01-09 |
CA2366787A1 (en) | 2000-10-12 |
JP5981214B2 (en) | 2016-08-31 |
BR0009448A (en) | 2002-01-08 |
JP2002541088A (en) | 2002-12-03 |
ES2333400T3 (en) | 2010-02-22 |
DK2266537T3 (en) | 2014-12-15 |
EP1985285A2 (en) | 2008-10-29 |
BRPI0009448B8 (en) | 2021-05-25 |
ES2524141T3 (en) | 2014-12-04 |
IL212390A (en) | 2014-08-31 |
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