IL145034A0 - Method for validating/invalidating target(s) and pathways - Google Patents
Method for validating/invalidating target(s) and pathwaysInfo
- Publication number
- IL145034A0 IL145034A0 IL14503400A IL14503400A IL145034A0 IL 145034 A0 IL145034 A0 IL 145034A0 IL 14503400 A IL14503400 A IL 14503400A IL 14503400 A IL14503400 A IL 14503400A IL 145034 A0 IL145034 A0 IL 145034A0
- Authority
- IL
- Israel
- Prior art keywords
- invalidating
- validating
- pathways
- target
- invalidating target
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12295099P | 1999-03-05 | 1999-03-05 | |
PCT/US2000/005643 WO2000051621A1 (en) | 1999-03-05 | 2000-03-02 | Method for validating/invalidating target(s) and pathways |
Publications (1)
Publication Number | Publication Date |
---|---|
IL145034A0 true IL145034A0 (en) | 2002-06-30 |
Family
ID=22405857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14503400A IL145034A0 (en) | 1999-03-05 | 2000-03-02 | Method for validating/invalidating target(s) and pathways |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1165093A4 (en) |
JP (1) | JP2002537792A (en) |
KR (1) | KR20020068262A (en) |
CN (1) | CN1348376A (en) |
AU (1) | AU3512300A (en) |
BR (1) | BR0009247A (en) |
CA (1) | CA2366055A1 (en) |
IL (1) | IL145034A0 (en) |
MX (1) | MXPA01008870A (en) |
WO (1) | WO2000051621A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2400206A1 (en) | 2000-02-17 | 2001-08-23 | Cv Therapeutics, Inc. | Method for identifying and using a2b adenosine receptor antagonists to mediate mammalian cell proliferation |
DE10346487A1 (en) * | 2003-10-02 | 2005-05-12 | Transmit Technologietransfer | Process for the preparation of a cell and / or tissue and / or disease phase specific drug |
EP1984511A2 (en) | 2006-02-13 | 2008-10-29 | Monsanto Technology LLP | Selecting and stabilizing dsrna constructs |
US8759297B2 (en) | 2006-08-18 | 2014-06-24 | Armagen Technologies, Inc. | Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns |
DE102007021443A1 (en) * | 2007-05-08 | 2008-11-13 | Brahms Aktiengesellschaft | Diagnosis and risk stratification using NT-proET-1 |
EP2182980A4 (en) | 2007-07-27 | 2012-04-18 | Armagen Technologies Inc | Methods and compositions for increasing alpha-iduronidase activity in the cns |
EP2408474B1 (en) | 2009-03-18 | 2019-06-26 | Armagen, Inc. | Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins |
EP3533467B1 (en) | 2009-10-09 | 2023-07-26 | Armagen, Inc. | Methods and compositions for increasing iduronate 2-sulfatase activity in the cns |
CN102169121B (en) * | 2010-02-25 | 2013-12-04 | 北京诺赛基因组研究中心有限公司 | New application of human kinase SBK1 (SH3-binding domain kinase 1) |
AU2012346448B2 (en) | 2011-12-02 | 2017-09-14 | Armagen, Inc. | Methods and compositions for increasing arylsulfatase A activity in the CNS |
WO2015009961A1 (en) * | 2013-07-19 | 2015-01-22 | Armagen Technologies, Inc. | Compositions and methods related to structures that cross the blood brain barrier |
US10538589B2 (en) | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
SI3093022T1 (en) | 2015-05-15 | 2019-12-31 | Sterna Biologicals Gmbh & Co. Kg | Gata-3 inhibitors for use in the treatment of th2-driven asthma |
CN114480406B (en) * | 2021-09-16 | 2024-01-30 | 广东翠点生物科技有限公司 | IL-1 signal path response element and application thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5994315A (en) * | 1995-06-07 | 1999-11-30 | East Carolina University | Low adenosine agent, composition, kit and method for treatment of airway disease |
WO2000042178A2 (en) * | 1999-01-13 | 2000-07-20 | Dupont Pharmaceuticals Company | Antagonist blockade of crf2 receptors for the treatment of psy chiatric disorders and the use of chimeric antisense oligonucleotides in in vivo cns studies of gene function |
-
2000
- 2000-03-02 AU AU35123/00A patent/AU3512300A/en not_active Abandoned
- 2000-03-02 BR BR0009247-9A patent/BR0009247A/en not_active IP Right Cessation
- 2000-03-02 MX MXPA01008870A patent/MXPA01008870A/en unknown
- 2000-03-02 IL IL14503400A patent/IL145034A0/en unknown
- 2000-03-02 JP JP2000602288A patent/JP2002537792A/en not_active Withdrawn
- 2000-03-02 KR KR1020017011238A patent/KR20020068262A/en not_active Application Discontinuation
- 2000-03-02 EP EP00913730A patent/EP1165093A4/en not_active Withdrawn
- 2000-03-02 CN CN00806759A patent/CN1348376A/en active Pending
- 2000-03-02 CA CA002366055A patent/CA2366055A1/en not_active Abandoned
- 2000-03-02 WO PCT/US2000/005643 patent/WO2000051621A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2000051621A1 (en) | 2000-09-08 |
EP1165093A4 (en) | 2002-07-24 |
BR0009247A (en) | 2001-11-20 |
CA2366055A1 (en) | 2000-09-08 |
JP2002537792A (en) | 2002-11-12 |
CN1348376A (en) | 2002-05-08 |
EP1165093A1 (en) | 2002-01-02 |
KR20020068262A (en) | 2002-08-27 |
MXPA01008870A (en) | 2004-08-12 |
AU3512300A (en) | 2000-09-21 |
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