IL136489A0 - Synthesis of cc-1065/duocarmycin analogs - Google Patents
Synthesis of cc-1065/duocarmycin analogsInfo
- Publication number
- IL136489A0 IL136489A0 IL13648998A IL13648998A IL136489A0 IL 136489 A0 IL136489 A0 IL 136489A0 IL 13648998 A IL13648998 A IL 13648998A IL 13648998 A IL13648998 A IL 13648998A IL 136489 A0 IL136489 A0 IL 136489A0
- Authority
- IL
- Israel
- Prior art keywords
- synthesis
- duocarmycin analogs
- duocarmycin
- analogs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6796097P | 1997-12-08 | 1997-12-08 | |
| PCT/US1998/025992 WO1999029642A1 (en) | 1997-12-08 | 1998-12-08 | Synthesis of cc-1065/duocarmycin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL136489A0 true IL136489A0 (en) | 2001-06-14 |
Family
ID=22079548
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13648998A IL136489A0 (en) | 1997-12-08 | 1998-12-08 | Synthesis of cc-1065/duocarmycin analogs |
| IL136489A IL136489A (en) | 1997-12-08 | 2000-05-31 | Synthesis of the dihydroindole c - ring to the cc-1065/duocarmycin analog |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL136489A IL136489A (en) | 1997-12-08 | 2000-05-31 | Synthesis of the dihydroindole c - ring to the cc-1065/duocarmycin analog |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6310209B1 (ja) |
| EP (1) | EP1037865A4 (ja) |
| JP (1) | JP2001525382A (ja) |
| AU (1) | AU1807999A (ja) |
| CA (1) | CA2313231A1 (ja) |
| IL (2) | IL136489A0 (ja) |
| NO (1) | NO317140B1 (ja) |
| NZ (1) | NZ504884A (ja) |
| WO (1) | WO1999029642A1 (ja) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9818730D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
| PT1413582E (pt) | 1998-08-27 | 2006-07-31 | Spirogen Ltd | Pirrolobenzodiazepinas dimericas |
| US6909006B1 (en) | 1999-08-27 | 2005-06-21 | Spirogen Limited | Cyclopropylindole derivatives |
| WO2001083482A1 (en) * | 2000-05-03 | 2001-11-08 | The Scripps Research Institute | Dna alkylating agent and activation thereof |
| AU9654201A (en) | 2000-10-02 | 2002-04-15 | Univ Emory | Triptolide analogs for the treatment of autoimmune and inflammatory disorders |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US7589180B2 (en) | 2001-05-11 | 2009-09-15 | Abbott Laboratories Inc. | Specific binding proteins and uses thereof |
| MXPA03011094A (es) * | 2001-05-31 | 2004-12-06 | Medarex Inc | Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello. |
| EP1469777A4 (en) * | 2002-01-09 | 2007-04-04 | Neoguide Systems Inc | APPARATUS AND METHOD FOR SPECTROSCOPIC COLON EXAMINATION |
| GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
| GB0321295D0 (en) | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
| RU2402548C2 (ru) * | 2004-05-19 | 2010-10-27 | Медарекс, Инк. | Химические линкеры и их конъюгаты |
| AU2005244980B2 (en) * | 2004-05-19 | 2011-09-15 | E. R. Squibb & Sons, L.L.C. | Chemical linkers and conjugates thereof |
| ES2386366T3 (es) * | 2005-02-18 | 2012-08-17 | Medarex, Inc. | Anticuerpo monoclonal humano contra el antígeno de membrana específico de la próstata (PSMA) |
| US7714016B2 (en) | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
| JP5290756B2 (ja) * | 2005-09-26 | 2013-09-18 | メダレックス インコーポレイテッド | 抗体−薬剤コンジュゲート及びその使用 |
| US7847105B2 (en) * | 2005-10-26 | 2010-12-07 | Medarex, Inc. | Methods and compounds for preparing CC-1065 analogs |
| WO2007059404A2 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
| US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
| KR20090122439A (ko) | 2007-02-21 | 2009-11-30 | 메다렉스, 인코포레이티드 | 단일 아미노산을 갖는 화학적 링커 및 이의 접합체 |
| JP5618549B2 (ja) | 2007-03-15 | 2014-11-05 | ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド | Ｅｇｆｒ抗体及びｓｒｃ阻害剤を用いる治療方法及び関連製剤 |
| JP5532486B2 (ja) | 2007-08-14 | 2014-06-25 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Ｅｇｆ受容体を標的とするモノクローナル抗体１７５ならびにその誘導体および用途 |
| KR20220035504A (ko) | 2008-04-30 | 2022-03-22 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
| AU2012395148B2 (en) | 2012-11-24 | 2016-10-27 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| ES2960619T3 (es) | 2014-02-28 | 2024-03-05 | Hangzhou Dac Biotech Co Ltd | Enlazadores cargados y sus usos para la conjugación |
| NZ739830A (en) | 2015-07-12 | 2021-12-24 | Hangzhou Dac Biotech Co Ltd | Bridge linkers for conjugation of cell-binding molecules |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| US20210308277A1 (en) | 2016-11-14 | 2021-10-07 | Hangzhou Dac Biotech Co., Ltd. | Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH652392A5 (de) * | 1982-02-10 | 1985-11-15 | Ciba Geigy Ag | Verfahren zur herstellung von in 2,3-stellung unsubstituierten indolen. |
| DE3706792A1 (de) * | 1987-03-03 | 1988-09-15 | Basf Ag | Verfahren zur herstellung von 7-chlor-chinolin-8-carbonsaeure |
| US5605896A (en) | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
| EP0563475B1 (en) | 1992-03-25 | 2000-05-31 | Immunogen Inc | Cell binding agent conjugates of derivatives of CC-1065 |
| JP3514490B2 (ja) | 1992-08-21 | 2004-03-31 | 杏林製薬株式会社 | トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法 |
| ES2220927T3 (es) | 1994-04-22 | 2004-12-16 | Kyowa Hakko Kogyo Co., Ltd. | Derivados de dc-89. |
| EP0934269A4 (en) * | 1996-05-31 | 2000-01-12 | Scripps Research Inst | CC-1065 ANALOGS AND DUOCARMYCINS |
| WO1998040068A1 (en) * | 1997-03-10 | 1998-09-17 | Eli Lilly And Company | Heterocyclic agents |
| JP2001519412A (ja) * | 1997-10-14 | 2001-10-23 | ザ スクリップス リサーチ インスティテュート | Ｃｃ−１０６５およびデュオカルマイシンのイソ−ｃｂｉおよびイソ−ｃｉ類似体 |
| US6534660B1 (en) * | 2002-04-05 | 2003-03-18 | Immunogen, Inc. | CC-1065 analog synthesis |
-
1998
- 1998-12-08 US US09/581,049 patent/US6310209B1/en not_active Expired - Fee Related
- 1998-12-08 EP EP98962954A patent/EP1037865A4/en not_active Withdrawn
- 1998-12-08 CA CA002313231A patent/CA2313231A1/en not_active Abandoned
- 1998-12-08 WO PCT/US1998/025992 patent/WO1999029642A1/en not_active Application Discontinuation
- 1998-12-08 JP JP2000524241A patent/JP2001525382A/ja not_active Withdrawn
- 1998-12-08 IL IL13648998A patent/IL136489A0/xx not_active IP Right Cessation
- 1998-12-08 NZ NZ504884A patent/NZ504884A/xx unknown
- 1998-12-08 AU AU18079/99A patent/AU1807999A/en not_active Abandoned
-
2000
- 2000-05-31 IL IL136489A patent/IL136489A/en unknown
- 2000-06-07 NO NO20002900A patent/NO317140B1/no unknown
-
2001
- 2001-10-30 US US10/001,611 patent/US20020082424A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL136489A (en) | 2006-07-05 |
| NZ504884A (en) | 2002-10-25 |
| NO317140B1 (no) | 2004-08-23 |
| NO20002900D0 (no) | 2000-06-07 |
| EP1037865A1 (en) | 2000-09-27 |
| EP1037865A4 (en) | 2004-03-31 |
| NO20002900L (no) | 2000-08-08 |
| AU1807999A (en) | 1999-06-28 |
| CA2313231A1 (en) | 1999-06-17 |
| US6310209B1 (en) | 2001-10-30 |
| WO1999029642A1 (en) | 1999-06-17 |
| JP2001525382A (ja) | 2001-12-11 |
| US20020082424A1 (en) | 2002-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |